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Hyperuricemia and Gout 

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  1. Open Access 01-12-2024 | Gout | OriginalPaper

    The association between Helicobacter pylori infection and the risk for gout in hyperuricemia patients in China – A cross-sectional study

    Helicobacter pylori ( H. pylori ) is a gram-negative spiral bacterium that colonizes in the gastric mucosa persistently, infecting approximately 4.4 billion people worldwide and varying considerably according to geographic region [ 1 ]. H. pylori …

  2. 16-03-2024 | Febuxostat | OriginalPaper

    Comparison of the efficacy and safety of benzbromarone and febuxostat in gout and hyperuricemia: a systematic review and meta-analysis

    Gout is an inflammatory arthritis that commonly affects both small and large bone joints. It is one of the most prevalent forms of arthritis in developed countries and also one of the most common inflammatory bone joint diseases in some developing …

  3. Open Access 01-12-2024 | Gout | OriginalPaper

    Relationship between gout, hyperuricemia, and obesity—does central obesity play a significant role?—a study based on the NHANES database

    Urate represents the final outcome of purine metabolism. Hyperuricemia is distinguished by the presence of abnormally elevated concentrations of urate in the bloodstream and is recognized as an antecedent to the development of gout. Gout

  4. Open Access 01-12-2024 | OriginalPaper

    Bisphenol A and its alternatives bisphenol S and F exposure with serum uric acid levels, hyperuricemia, and gout prevalence among US adults: a nationally representative cross-sectional study

    Uric acid, derived from purine metabolism, contributed to approximately 50% of the antioxidant capacity in plasma. However, it also has harmful pro-oxidant effects including oxidative damage, inflammatory response, and endothelial dysfunction [ 1 …

  5. Open Access 01-12-2023 | Febuxostat | OriginalPaper

    Response to febuxostat according to clinical subtypes of hyperuricemia: a prospective cohort study in primary gout

    Gout is a common inflammatory condition caused by monosodium urate crystal deposition due to elevated serum urate (SU) concentration (hyperuricemia) [ 1 ]. The SU concentration is determined by a balance between urate production and elimination.

  6. Open Access 01-12-2023 | Gout | OriginalPaper

    A metabonomic study to explore potential markers of asymptomatic hyperuricemia and acute gouty arthritis

    Gout is an inflammation and tissue damage caused by monosodium urate (MSU) deposition in bone joints, kidneys, and subcutaneous areas. It is directly related to hyperuricemia caused by purine metabolism disorder and/or reduction of uric acid …

  7. Open Access 01-12-2023 | Gout | OriginalPaper

    Alterations in lipidome profiles distinguish early-onset hyperuricemia, gout, and the effect of urate-lowering treatment

    Gout is a prevalent form of inflammatory arthritis, with a rising incidence [ 1 , 2 ], burdening individual health and impacting healthcare systems [ 3 ]. Reported estimates of gout prevalence range from 2.7 to 6.7% in countries with a Western …

  8. Open Access 01-12-2023 | Gout | OriginalPaper

    Metabolomic analysis for asymptomatic hyperuricemia and gout based on a combination of dried blood spot sampling and mass spectrometry technology

    Gout, the most common inflammatory arthritis, is induced by the deposition of monosodium urate (MSU) crystals in joints and soft tissues or the supersaturation of uric acid (UA) in extracellular fluid [ 1 ]. It has been reported to affect up to …

  9. 26-04-2023 | Hyperuricemia and Gout | ReviewPaper

    Prevalence of Diabetes in Patients with Hyperuricemia and Gout: A Systematic Review and Meta-analysis

    The International Diabetes Federation Diabetes Atlas reported that 537 million people were living with diabetes in 2021 [ 1 ]. In addition, the number of patients with diabetes is estimated to reach 643 million by 2030 and 783 million by 2045 [ 1 …

  10. Open Access 01-12-2024 | OriginalPaper

    Nonlinear relationship between oxidative balance score and hyperuricemia: analyses of NHANES 2007–2018

    Uric acid is the final byproduct of purine metabolism in humans. The kidneys eliminate around two-thirds of uric acid as free sodium urate in urine, while the remaining is either excreted through the intestines or broken down by intestinal …

  11. 06-12-2023 | Gout | OriginalPaper

    Upregulation of CD39 During Gout Attacks Promotes Spontaneous Remission of Acute Gouty Inflammation

    Gout is a self-limiting form of inflammatory arthropathy caused by the formation of urate crystals due to hyperuricemia. The resolution of gout involves the transition of proinflammatory M1-type macrophages to anti-inflammatory M2-type …

  12. Open Access 01-12-2024 | Gout | OriginalPaper

    Assessment of the correlation between KAP scores regarding sugar-sweetened beverage consumption and hyperuricemia amongst Chinese young adults

    Hyperuricemia refers to an elevated concentration of uric acid in the blood (i.e., blood uric acid  ≥  420 µmol/L), potentially leading to gout and nephrolithiasis [ 1 , 2 ]. Hyperuricemia results from the interplay of increased uric acid …

  13. Open Access 01-12-2024 | Allopurinol | OriginalPaper

    Renal interstitial fibrotic assessment using non-Gaussian diffusion kurtosis imaging in a rat model of hyperuricemia

    Hyperuricemia (HUA) is a metabolic disease that results from increased production and/or reduced excretion of serum uric acid (SUA) [ 1 ]. The prevalence of both HUA and gout has increased worldwide, making these major public health problems [ 2 …

  14. Open Access 01-12-2024 | Gout | OriginalPaper

    Interpretable machine learning framework to predict gout associated with dietary fiber and triglyceride-glucose index

    Gout is one of the most common forms of inflammatory arthritis caused by a sustained elevation of serum uric acid (UA) above the dissolved saturation level of 408 µmol/L, leading to an inflammatory response and pain due to the precipitation of …

  15. Open Access 01-12-2024 | Achilles Tendon Rupture | OriginalPaper

    Hyperuricemia as an independent risk factor for achilles tendon rupture in male: a case–control study

    Achilles tendon ruptures (ATR) are a common injury associated with exercise, with an incidence ranging from 5 to 50 cases per 100,000 person-years and appearing to be on the rise in recent decades [ 1 – 3 ]. Achilles tendon rupture can severely …

  16. Open Access 01-12-2024 | OriginalPaper

    Associations between hyperuricemia and ultrasound-detected knee synovial abnormalities in middle-aged and older population: a cross-sectional study

    Knee synovial abnormalities are commonly found in the middle-aged and older population with a prevalence ranging from 18.1–53.1% for synovial hypertrophy, 46.6–69.7% for effusion and 4.9–31.8% for Power Doppler signal (PDS), respectively [ 1 – 3 ].

  17. 31-10-2023 | Gout | OriginalPaper

    Clustering of gout-related comorbidities and their relationship with gout flares: a data-driven cluster analysis of eight comorbidities

    Gout flares are extremely painful episodes of acute joint inflammation induced by monosodium urate crystals, characterized by sudden onset of joint pain, erythema, heat, swelling, and dysfunction [ 1 ].

  18. Open Access 01-12-2023 | Gout | OriginalPaper

    Hyperuricemia and gout increased the risk of long-term mortality in patients with heart failure: insights from the National Health and Nutrition Examination Survey

    Serum uric acid (SUA) is the ultimate product of purine metabolism, which is mainly synthesized in the liver and excreted via the renal tract and intestines [ 1 , 2 ]. Humans are exposed to > 50 times higher SUA concentrations than other mammals …

  19. 06-05-2024 | Gout | Online First

    Empagliflozin and Risk of Incident Gout: Analysis from the EMPagliflozin Comparative Effectiveness and SafEty (EMPRISE) Cohort Study

    Sodium-glucose co-transporter-2 (SGLT2) inhibitors are a newer class of oral glucose-lowering medications that lower serum glucose independent of insulin by blocking glucose reabsorption in the proximal tubule to induce glucosuria. In addition …

  20. 10-12-2023 | OriginalPaper

    Higher dietary acid load is associated with the risk of hyperuricemia

    Uric acid is a product of amino acid metabolism in the liver. In high cell turnover states, the breakdown of purines also leads to the release of uric acid [ 1 ]. Hyperuricemia, abnormally elevated serum urate levels, is caused by an increase in …

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