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Fibrinolytic Therapy 

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  1. Open Access 01-12-2023 | Fibrinolytic Therapy | OriginalPaper

    Fibrinolytic therapy use for ST-segment elevation myocardial infarction and long-term outcomes in China: 2-year results from the China Acute Myocardial Infarction Registry

    Although primary percutaneous coronary intervention (PCI) has replaced fibrinolysis as the preferred reperfusion strategy in the current management of ST-segment elevation myocardial infarction (STEMI) [ 1 , 2 ], the latter is still the mainstay in …

  2. Open Access 01-12-2022 | Alteplase | OriginalPaper

    Retrospective review comparing intrapleural fibrinolytic therapy (alteplase) and surgical intervention in complex pleural effusion

    Pleural effusion is a common medical problem, with varied treatment options depending on the cause. [ 1 ] The two commonest causes of pleural effusion are parapneumonic and malignant effusion, with an estimated annual incidence of 300,000 and …

  3. Open Access 01-12-2021 | Streptokinase | ReviewPaper

    The use of fibrinolytic therapy for parapneumonic effusion in pregnancy: a case report and a review

    The use of intrapleural fibrinolytics for complicated parapneumonic effusion has been shown to be an effective and safe alternative to surgery. However, there is limited evidence about its use during pregnancy. We present a case and a review of …

  4. 22-04-2022 | Tissue Plasminogen Activator | OriginalPaper

    Efficacy of standardizing fibrinolytic therapy for parapneumonic effusion

    Chest tube placement with pleural fibrinolytic medication administration has been established as an effective first-line treatment option in pediatric pneumonia with complicated pleural effusion [ 1 – 5 ]. Pleural infection includes parapneumonic …

  5. 01-04-2021 | Tissue Plasminogen Activator | ReviewPaper

    Can fibrinolytic therapy be clinically useful in severe pneumonia caused by COVID-19?

  6. 01-01-2021 | Hydrocephalus | OriginalPaper

    Efficacy and safety of intraventricular fibrinolytic therapy for post-intraventricular hemorrhagic hydrocephalus in extreme low birth weight infants: a preliminary clinical study

    Remarkable progress in neonatal intensive care has dramatically improved survival rates in low birth weight infants (LBWIs) [ 1 ] [ 2 ]. However, intraventricular hemorrhage (IVH) has persisted as a troublesome complication. The vulnerable blood …

  7. 01-03-2021 | Fibrinolytic Therapy | Erratum

    Correction to: Effect of irrigation on fibrinolytic rtPA therapy in a clot model of intracerebral haemorrhage: a systematic in vitro study

    The correct name should be: Julia Masomi-Bornwasser.

  8. 01-12-2019 | Streptokinase | EditorialNotes

    Intrapleural Fibrinolytic Therapy in Empyema Thoracis: Where are we now and where do we go from here?

  9. 01-03-2004 | ReviewPaper

    Adjunctive Use of Direct Thrombin Inhibitors in Patients Receiving Fibrinolytic Therapy for Acute Myocardial Infarction

    The direct thrombin inhibitors hirudin and bivalirudin inhibit both fluid-phase and clot-bound thrombin. These agents have been extensively studied in clinical trials in comparison with intravenous unfractionated heparin (UFH), as adjuncts to …

  10. 01-02-2015 | OriginalPaper

    Admission Hyperglycemia Is Associated with Failed Reperfusion Following Fibrinolytic Therapy in Patients with STEMI: Results of a Retrospective Study

    Present guidelines recommend fibrinolytic therapy (FT) in patients who present with ST-segment elevation myocardial infarction (STEMI) when primary percutaneous coronary intervention (PCI) cannot be performed quickly after initial presentation at …

  11. 01-10-2018 | BriefCommunication

    Ticagrelor versus clopidogrel after fibrinolytic therapy in patients with ST-elevation myocardial infarction: a systematic review and meta-analysis of randomized clinical trials

    Dual antiplatelet therapy with aspirin and clopidogrel are recommended as adjuncts to fibrinolytic-treated patients with ST-elevation myocardial infarction (STEMI). However, the role of switching to ticagrelor within 24 h of fibrinolytics compared …

  12. 01-06-2018 | OriginalPaper

    Effect of irrigation on fibrinolytic rtPA therapy in a clot model of intracerebral haemorrhage: a systematic in vitro study

    About 10–15% of all stroke incidents are caused by spontaneous intracerebral haemorrhage (ICH) [ 1 ]. Such events are life threatening, with a mortality of up to 50% within the first 30 days [ 1 , 2 ]. Another 30% of those who survive never regain …

  13. Open Access 01-12-2017 | OriginalPaper

    Assessment of neurologists’ knowledge regarding intravenous fibrinolytic therapy for acute stroke in Shanxi province in China

    Stroke is the second leading cause of death worldwide and the leading cause of death in China [ 1 , 2 ]. The survivors of stroke have the highest ratio of severe overall disability among sufferers of chronic diseases [ 3 ]. It is a huge burden on …

  14. 01-05-2016 | OriginalPaper

    Intrapleural Fibrinolytic Therapy for Residual Coagulated Hemothorax After Lung Surgery

    Hemorrhage after pulmonary resection is uncommon, occurring in 0.1–3 % of thoracotomies and <2 % of video-assisted thoracoscopic surgeries (VATS) [ 1 – 5 ]. Re-operation for hemothorax is required in <2 % of cases [ 3 , 6 ]. Slow hemorrhage is an …

  15. 01-12-1998 | OriginalPaper

    Results of the PHLEFI Study (PHLEbothrombosis-FIbrinolytic therapy): A prospective, multicenter study of the fate of 1498 patients receiving fibrinolytic therapy for deep vein thrombosis

    Fibrinolytic therapy for DVT has not gained universal acceptance. A notable percentage of DVTs in Germany are treated by clot-dissolving methods. This is in contrast to clinical practice in the United States where fibrinolytic treatment for DVT is …

  16. 01-06-1997 | OriginalPaper

    Results of the PHLEFI study (PHLEbothrombosis-FIbrinolytic therapy): A prospective, multicenter study of the fate of 1498 patients receiving fibrinolytic therapy for deep vein thrombosis

    Fibrinolytic therapy for DVT has not gained universal acceptance. A notable percentage of DVTs in Germany are treated by clot-dissolving methods. This is in contrast to clinical practice in the United States where fibrinolytic treatment for DVT is …

  17. 01-01-2004 | OriginalPaper

    Acute myocardial infarction: Fibrinolytic therapy

    Fibrinolytic therapy (also known as thrombolytic therapy) is an established, simple, widely available and cost-effective treatment option for acute myocardial infarction. Adjunctive use of antiplatelet and antithrombin therapies has been shown to …

  18. 01-09-2011 | BriefCommunication

    Intrapleural Fibrinolytic Therapy in a Neonate

    Pleural effusions are common complications of pediatric bacterial pneumonias. Failure to control the pleural effusions may lead to progressive disease and can result in complicated parapneumonic effusions. The natural history of a complicated …

  19. 01-02-2016 | ReviewPaper

    Drug Treatment of STEMI in the Elderly: Focus on Fibrinolytic Therapy and Insights from the STREAM Trial

    Elderly patients constitute a large and growing proportion of ST-elevation myocardial infarction (STEMI) patients, yet they have been under-represented or even excluded from reperfusion trials. Despite evidence that fibrinolysis improves outcomes …

  20. 01-01-2015 | OriginalPaper

    Fibrinolytic Therapy for Mechanical Pulmonary Valve Thrombosis

    Treatment of prosthetic heart valve thrombosis using intravenous thrombolytics, although an acceptable alternative to surgery, is not complication free, and the literature has a dearth of data on the subject. This study analyzed the results of …

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