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  1. 01-12-2020 | Prostate Cancer | Original Research

    LINC00992 contributes to the oncogenic phenotypes in prostate cancer via targeting miR-3935 and augmenting GOLM1 expression

    Clinically, prostate cancer manifests as a dominating cause of male-related death worldwide and is characterized as the most continually occurred tumor among men in the United States [ 1 ]. The biggest challenge is the detectable bone metastases in …

  2. Open Access 01-12-2022 | Bronchial Asthma | OriginalPaper

    miR-3934 regulates the apoptosis and secretion of inflammatory cytokines of basophils via targeting RAGE in asthma

    Asthma is a common respiratory disease characterized by chronic airway inflammation and hyperresponsiveness; its symptoms include recurrent wheeze, shortness of breath, chest tightness and cough [ 1 ]. Asthma affects more than 270 million people …

  3. Open Access 01-12-2021 | Pre-Eclampsia | OriginalPaper

    MicroRNA-3935 promotes human trophoblast cell epithelial-mesenchymal transition through tumor necrosis factor receptor-associated factor 6/regulator of G protein signaling 2 axis

    Preeclampsia (PE), a relatively common pregnancy disorder, is still one of the leading causes of maternal and neonatal morbidity and mortality worldwide, and in the worst cases, may threaten the survival of both mother and baby [ 1 – 3 ]. However …

  4. Open Access 01-12-2017 | OriginalPaper

    Relationship between GNAS1 T393C polymorphism and aseptic loosening after total hip arthroplasty

    The number of total hip arthroplasties (THA) will increase noticeably in the next years. For 2030, Kurtz et al. predicted a demand of about 600,000 THA in the United States [ 1 ]. Unfortunately, revision surgery after THA is often needed due to …

  5. 01-11-2015 | OriginalPaper

    Prognostic value of age in neurological cancer: an analysis of 22,393 cases from the SEER database

    Although the risk of neurological cancer (NC) is age-dependent, few studies have evaluated the prognostic value of age in determining NC survival in a large population. The aim of this retrospective study was to compare the long-term survival of …

  6. 01-09-2016 | Letter

    Reply to the letter to the editor “In response to: The effects of different environmental pH on healing of tympanic membrane: an experimental study” 10.1007/s00405-016-3931-7

  7. Open Access 01-09-2013 | BriefCommunication

    Prospective study of 393 adolescent thoracic hyperkyphosis patients treated by the Lyon method

    Unlike scoliosis, there is no alteration in respiratory function with hyperkyphosis[ 1 ]. The resulting problems are mainly related to aesthetics and pain. The various conservative orthopedic treatments were discussed at the 7th SOSORT consensus …

  8. 01-12-2010 | OriginalPaper

    GNAS1 T393C polymorphism and disease progression in patients with malignant melanoma

    Early detection of metastasis is one of the aims of follow-up examination in patients with malignant melanoma since once metastasized, despite a variety of therapeutic options e. g. chemo- and/or immunotherapy, patients suffering from malignant …

  9. 01-03-2016 | OriginalPaper

    Association of the COQ2 V393A variant with risk of multiple system atrophy in East Asians: a case–control study and meta-analysis of the literature

    Recent studies in Japan have associated multiple system atrophy (MSA), a neurodegenerative disease of uncertain etiology, with polymorphism in the COQ2 gene. This led us to explore whether the same polymorphism is associated with MSA in Han …

  10. 01-06-2004 | OriginalPaper

    The detection and analysis of estrogen and progesterone receptors in breast cancer (report of 1,393 patients)

  11. 01-12-2014 | OriginalPaper

    Homozygous GNAS 393C-Allele Carriers with Locally Advanced Esophageal Cancer Fail to Benefit from Platinum-Based Preoperative Chemoradiotherapy

  12. 01-08-2011 | OriginalPaper

    The GNAS1 T393C single nucleotide polymorphism predicts the natural postoperative course of complete resected esophageal cancer

    Esophageal cancer (EC) is a highly aggressive disease and the median survival despite multimodal therapy approach remains <22 months only [ 1 , 2 ]. Even histologically verified lymph-node negative patients are likely to develop a systemic relapse …

  13. 01-07-2015 | OriginalPaper

    Lack of evidence for an association between the V393A variant of COQ2 and amyotrophic lateral sclerosis in a Han Chinese population

    Amyotrophic lateral sclerosis (ALS) is a progressive disorder involving the degeneration of motor neurons. ALS shares pathogenic characteristics and genetic risk factors with multiple system atrophy (MSA). Here we examine whether a variant of the …

  14. 01-05-2013 | OriginalPaper

    DNA Ploidy is an Independent Predictor of Survival in Breast Invasive Ductal Carcinoma: A Long-term Multivariate Analysis of 393 Patients

  15. Open Access 01-12-2013 | OriginalPaper

    Hepatitis B surface antigen prevalence among 12 393 rural women of childbearing age in Hainan Province, China: a cross-sectional study

    Hepatitis B virus (HBV) infection is an important public health problem worldwide, more than two billion people (one third of the world’s population) have been infected with HBV, and between 350 and 400 million people have chronic liver infections …

  16. Open Access 01-12-2014 | OriginalPaper

    Serial enumeration of circulating tumor cells predicts treatment response and prognosis in metastatic breast cancer: a prospective study in 393 patients

    Apart from the expression of hormone and human epidermal growth factor receptors there are as yet hardly any predictive factors for treatment efficacy in patients with metastatic breast cancer (MBC) despite a rapidly growing number of treatment …

  17. 01-06-2013 | OriginalPaper

    Lower urinary tract symptoms in relation to region of birth in 95,393 men living in Australia: the 45 and Up Study

    Lower urinary tract symptoms (LUTS) are common among men worldwide, and prevalence increases substantially with age. International studies indicate the prevalence of moderate-to-severe LUTS is 20–40 % for men aged 60 and over [ 1 , 2 ]. In addition …

  18. 01-11-2007 | OriginalPaper

    The T393C polymorphism in the gene GNAS1 of G protein is associated with survival of patients with invasive breast carcinoma

    The GNAS1 locus encodes the G(alpha)s protein which stimulates the formation of cyclic AMP (cAMP). Subsequently the cAMP pathway mediates various pleiotropic effects including regulation of apoptosis and proliferation. We have recently shown that …

  19. Open Access 01-12-2013 | OriginalPaper

    In vitro susceptibility to quinine and microsatellite variations of the Plasmodium falciparum Na+/H+ exchanger transporter (Pfnhe-1) gene in 393 isolates from Dakar, Senegal

    Although the World Health Organization (WHO) recommends replacing quinine (QN) with artesunate due to its improved efficacy and the higher tolerance of the drug in both adults and children [ 1 , 2 ], QN remains a first-line treatment for severe …

  20. Open Access 01-06-2013 | Abstract

    P393: Assessment of the practice of sterilization of medical devices in the services of surgery of chu the university hospital Yalgado Ouedraogo (Chu-Yo)

    The consolidation of sterilization on the same site is the only way for institutions to maintain internal control of the sterilization process for medical devices.

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