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  1. Open Access 01-12-2024 | OriginalPaper

    Associations between long-term night shift work and incidence of chronic obstructive pulmonary disease: a prospective cohort study of 277,059 UK Biobank participants

    Chronic obstructive pulmonary disease (COPD) is a progressive disease characterized by consistent restriction of airflow along with varying degrees of obstructive bronchiolitis and parenchymal destruction [ 1 – 3 ]. It is estimated that over 350 …

  2. Open Access 01-12-2023 | Hepatocellular Carcinoma | OriginalPaper

    Prognostic implications of alpha-fetoprotein and C-reactive protein elevation in hepatocellular carcinoma following resection (PACE): a large cohort study of 2770 patients

    Hepatocellular carcinoma (HCC) continues to be one of the most pervasive malignancies worldwide, with both disease burden and mortality rates escalating [ 1 , 2 ]. Liver resection emerges as a pivotal, potentially curative approach for HCC …

  3. Open Access 01-12-2021 | Von Willebrand Disease | OriginalPaper

    The disulfide bond Cys2724-Cys2774 in the C-terminal cystine knot domain of von Willebrand factor is critical for its dimerization and secretion

    VWF is a large-molecular multimerized glycoprotein synthesized and secreted by endothelial cells and megakaryocytes. This protein has multiple contributions to the hemostatic process: it mediates platelet adhesion and aggregation at sites of …

  4. Open Access 01-06-2021 | Denture | OriginalPaper

    Multivariate analysis of the influence of peri-implant clinical parameters and local factors on radiographic bone loss in the posterior maxilla: a retrospective study on 277 dental implants

    Peri-implant bone loss has a multifactorial pathogenesis and it is linked to a multitude of risk factors related to the dental implant (i.e., surface modifications, position, type of prosthesis, implant-abutment connection, timing of loading), to …

  5. 03-08-2022 | Acute Myeloid Leukemia | OriginalPaper

    CD277 agonist enhances the immunogenicity of relapsed/refractory acute myeloid leukemia towards Vδ2+ T cell cytotoxicity

    Relapse and refractoriness remain the major obstacles in clinical treatment of acute myeloid leukemia (AML). Efficacy of current therapeutic strategies for relapsed/refractory (R/R) AML is generally unsatisfying. Vδ2+ T cells have become an …

  6. 01-11-2020 | Cerebellopontine Angle Tumor | Letter

    Letter to the Editor regarding “Single-sided deafness after sudden hearing loss: late effect on cochlear nerve size” by Islamoglu et al. European Archives of Oto-Rhino-Laryngology (2020) 277:2423–2426

  7. 01-09-1997 | OriginalPaper

    Thyroid-stimulating antibody and TSH-binding inhibitor immunoglobulin in 277 Graves’ patients and in 686 normal subjects

    TSH receptor antibodies (TRAb) are believed to cause hyperthyroidism of Graves’ disease. Thyroid-stimulating antibody (TSAb) and TSH-binding inhibitor immunoglobulin (TBII) have been measured as TRAb to diagnose Graves’ disease and to follow …

  8. 01-01-1999 | BriefCommunication

    BIII 277CL

    BIII 277, BIII 281CL
  9. 01-09-2018 | OriginalPaper

    Real-world antidiabetic drug use and fracture risk in 12,277 patients with type 2 diabetes mellitus: a nested case–control study

    Patients with type 2 diabetes mellitus (T2DM) have an increased risk of bone fractures [ 1 – 5 ] despite a normal to high bone mineral density (BMD) [ 6 , 7 ], compared with non-diabetic patients. The mechanisms underlying this excess fracture risk …

  10. 01-11-2018 | OriginalPaper

    Comparative Characteristics of Patients with Type 2 Diabetes Mellitus Treated by Bariatric Surgery Versus Medical Treatment: a Multicentre Analysis of 277,862 Patients from the German/Austrian DPV Database

    The global prevalence of type 2 diabetes mellitus (T2DM) is increasing rapidly and is one of the major threats to human health worldwide [ 1 , 2 ]. This goes in parallel with the current obesity epidemic [ 3 ], because obesity and T2DM are two …

  11. 01-01-2018 | OriginalPaper

    Lumbar interbody fusion with utilization of recombinant human bone morphogenetic protein: a retrospective real-life study about 277 patients

    The purpose of this study was to report an independent real-life experience about the use of recombinant human bone morphogenetic protein 2 in lumbar interbody fusion with a special focus on complications. This is a retrospective single-center …

  12. 01-03-2009 | OriginalPaper

    Ameliorative effect of PN-277 on laser-induced retinal damage

    A damage to neural cells due to any cause triggers a process of degeneration in nerve cells adjacent to the primarily injured ones [ 1 ]. This process of secondary degeneration starts by the release of various noxious compounds from the primarily …

  13. Open Access 01-08-2013 | OriginalPaper

    Results of transoral laser microsurgery for supraglottic carcinoma in 277 patients

    The objective of the study was to evaluate the oncological and functional results of transoral laser microsurgery (TLM) in patients with supraglottic laryngeal squamous cell carcinoma. Between June 1980 and December 2006, 277 patients with …

  14. 01-04-1999 | OriginalPaper

    Noma: the Sokoto approach (Eur J Plast Surg [1998] 21:277)

  15. 01-04-2003 | OriginalPaper

    Farnesyltransferase inhibitor FTI-277 prevents autocrine growth stimulation of neuroblastoma by BDNF

    Neuroblastoma is an embryonal tumor derived from cells of the neural crest that in normal embryogenesis develop into chromaffin cells of the adrenal medulla or the neuronal and Schwann cells of autonomic ganglia. The embryogenesis of the autonomic …

  16. Open Access 01-12-2011 | Abstract

    Hyper-IgD syndrome: a new mutation (p.R277G) with a severe phenotype

    Hyperimmunoglobulin D Syndrome (HIDS is a rare autosomal recessive condition caused by mutations in the Mevalonate Kinase (MVK) gene that codes for MVK, an essential enzyme in the isoprenoid pathway. It shows a wide phenotypic spectrum probably …

  17. 01-02-2007 | OriginalPaper

    The G277S transferrin mutation does not affect iron absorption in iron deficient women

    The prevalence of iron deficiency has been estimated to be between 8% and 33% of young women in Europe [ 1 ], 10%–16% in the United States [ 2 ], and 42% in developing countries [ 3 ].

  18. 01-12-2013 | OriginalPaper

    Too tight to give birth? Assessment of pelvic floor muscle function in 277 nulliparous pregnant women

    A recent Cochrane review concluded that pregnant women without prior urinary incontinence (UI) who were randomized to intensive antenatal pelvic floor muscle training (PFMT) were 30 % less likely to report UI up to 6 months postpartum than women …

  19. Open Access 01-12-2010 | OriginalPaper

    Body piercing and tattoo: awareness of health related risks among 4,277 Italian secondary school adolescents

    The number of youngsters acquiring body art has reportedly been increasing in recent years [ 1 – 3 ] and a list of related medical complications has been documented [ 1 , 4 – 10 ].

  20. 01-08-2012 | OriginalPaper

    Association between FTO gene polymorphism and cancer risk: evidence from 16,277 cases and 31,153 controls

    A recent genome-wide association study showed that the rs9939609 polymorphism in the fat mass and obesity-associated (FTO) gene was associated with body mass index (BMI)/obesity in Europeans. Subsequently, several studies have investigated the …

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