Top

Published in:

01-10-2010

To Resect or not the Primary Tumor in Metastatic Colorectal Cancer: Letter to the Editor

Authors: Christos G. Katsios, Georgios Baltogiannis

Published in: World Journal of Surgery | Issue 10/2010

Excerpt

Colorectal cancer (CRC) is one of the most common tumors in the US, Europe, and worldwide but with a relatively good prognosis. In the adjuvant setting, high long-term survival rates have been reported, and even in the metastatic setting, with the use of systemic chemotherapy the median survival time has been improved to roughly 20 months. The addition of biologic agents such as cetuximab or panitumab has raised expectation for further survival improvement. With these developments, an old problem in surgical oncology has now been updated. Is the decision to resect the primary tumor, when it is locally completely resectable, correct, or will resection harm patients with a stage IV disease? …

Stillwell AP, Buettner PG, Ho YH (2010) Meta-analysis of survival of patients with stage IV colorectal cancer managed with surgical resection versus chemotherapy alone. World J Surg 34(4):797–807CrossRefPubMed

Roukos DH (2009) Personalized cancer diagnostics and therapeutics. Expert Rev Mol Diagn 9(3):227–229CrossRefPubMed

Roukos DH (2009) Genome-wide association studies: how predictable is a person’s cancer risk? Expert Rev Anticancer Ther 9(4):389–392CrossRefPubMed

Roukos DH, Ziogas D (2009) Human genetic and structural genomic variation: would genome-wide association studies be the solution for cancer complexity like Alexander the Great for the “Gordian Knot”? Ann Surg Oncol 16(3):774–775CrossRefPubMed

Roukos DH (2010) Targeting gastric cancer with trastuzumab: new clinical practice and innovative developments to overcome resistance. Ann Surg Oncol 17:14–17CrossRefPubMed

Roukos DH (2010) Bionetworks-based personalized medicine versus comparative-effectiveness research or harmonization of both in cancer management? Expert Rev Mol Diagn 10(3):247–250CrossRefPubMed

Roukos DH (2010) Beyond HER2 and trastuzumab: heterogeneity, systems biology, and cancer origin research may guide the future for personalized treatment of very early but aggressive breast cancer. J Clin Oncol. doi:10.1200/JCO.2009.27.7061. [Epub ahead of print]

Ziogas D, Roukos DH (2009) Genetics and personal genomics for personalized breast cancer surgery: progress and challenges in research and clinical practice. Ann Surg Oncol 16(7):1771–1782CrossRefPubMed

Roukos DH (2010) Systems medicine: a real approach for future personalized oncology? Pharmacogenomics 11(3):283–287CrossRefPubMed

10.

Roukos DH, Ziogas D (2010) From tumor size and HER2 status to systems oncology for very early breast cancer treatment. Expert Rev Anticancer Ther 10(2):123–128CrossRefPubMed

11.

Roukos DH (2009) Radiation therapy for breast cancer. N Engl J Med 360(13):1362CrossRefPubMed

12.

Roukos DH (2010) Novel clinico-genome network modeling for revolutionizing genotype-phenotype-based personalized cancer care. Expert Rev Mol Diagn 10(1):33–48CrossRefPubMed

13.

Ziogas D, Roukos DH (2009) CDH1 testing: can it predict the prophylactic or therapeutic nature of total gastrectomy in hereditary diffuse gastric cancer? Ann Surg Oncol 16(10):2678–2681CrossRefPubMed

14.

Roukos DH, Tzakos A, Zografos G (2009) Current concerns and challenges towards tailored anti-angiogenic therapy in cancer. Expert Rev Anticancer Ther 9(10):1413–1416CrossRef

Title: To Resect or not the Primary Tumor in Metastatic Colorectal Cancer: Letter to the Editor
Authors: Christos G. Katsios
Georgios Baltogiannis
Publication date: 01-10-2010
Publisher: Springer-Verlag
Published in: World Journal of Surgery / Issue 10/2010
Print ISSN: 0364-2313
Electronic ISSN: 1432-2323
DOI: https://doi.org/10.1007/s00268-010-0614-1

Keynote webinar | Spotlight on medication adherence

Springer Medicine

To Resect or not the Primary Tumor in Metastatic Colorectal Cancer: Letter to the Editor

Excerpt

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Excerpt

Please log in to get access to this content

Other articles of this Issue 10/2010

Diagnosis and Treatment of Diffuse Cavernous Hemangioma of the Rectum: Report of 17 Cases

Reply: Apples, Oranges, Metastatic Colorectal Cancer: has the Time for a Randomized Trial Come?

The Academic Discipline of Tropical Surgery

Preincisional Versus Postincisional Administration of Parecoxib in Colorectal Surgery: Effect on Postoperative Pain Control and Cytokine Response. A Randomized Clinical Trial

Hypoparathyroidism after Total Parathyroidectomy plus Subcutaneous Autotransplantation for Secondary Hyperparathyroidism—Any Side Effects?

Repeat Resection of Pulmonary Metastasis Is Beneficial for Patients with Colorectal Carcinoma