Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress 2023 EHA Congress 2023 ASCO Annual Meeting
Clinical Collections
Advances in Alzheimer’s

Keynote webinar | Spotlight on sleep in brain health

LIVE: Thursday 2nd May 2024, 18:00-19:30 (CEST)

Quality sleep is essential for health. But what happens to our brains when sleep patterns are disturbed? Join our experts to explore the interplay between sleep disruption and neurological diseases, and the questions that you need to be asking your patients to help you prevent the harmful effects of sleep deprivation.
ADVANCED SEARCH
Log in
Top
Annals of Surgical Oncology
Published in: Annals of Surgical Oncology 1/2010

Open Access 01-01-2010 | Gastrointestinal Oncology

Targeting Gastric Cancer with Trastuzumab: New Clinical Practice and Innovative Developments to Overcome Resistance

Author: Dimitrios H. Roukos, MD

Published in: Annals of Surgical Oncology | Issue 1/2010

Login to get access

Excerpt

At last, following decades of research endeavor, clinical success is here. A new molecular classification and novel targeted therapy can improve poor oncological outcomes of some patients with gastric cancer. …
Literature
1.
Burstein HJ. The distinctive nature of HER2-positive breast cancers. N Engl J Med. 2005;353(16):1652–4.CrossRefPubMed
2.
Gschwind A, Fischer OM, Ullrich A. The discovery of receptor tyrosine kinases: targets for cancer therapy. Nat Rev Cancer. 2004;4(5):361–70.CrossRefPubMed
3.
Baselga J, Swain SM. Novel anticancer targets: revisiting ERBB2 and discovering ERBB3. Nat Rev Cancer. 2009;9(7):463–75.CrossRefPubMed
4.
Gravalos C, Jimeno A. HER2 in gastric cancer: a new prognostic factor and a novel therapeutic target. Ann Oncol. 2008;19(9):1523–9.CrossRefPubMed
5.
Van Cutsem E, Kang Y, Chung H, et al. Efficacy results from the ToGA trial: A phase III study of trastuzumab added to standard chemotherapy (CT) in first-line human epidermal growth factor receptor 2 (HER2)-positive advanced gastric cancer (GC). J Clin Oncol. 2009;27:18s (suppl; abstr LBA4509).CrossRef
6.
7.
Jones S, Zhang X, Parsons DW. Core signaling pathways in human pancreatic cancers revealed by global genomic analyses. Science. 2008;321(5897):1801–6.CrossRefPubMed
8.
Roukos DH. Personalized cancer diagnostics and therapeutics. Expert Rev Mol Diagn. 2009;9(3):227–9.CrossRefPubMed
9.
Diestock TS. Personalizing medicine: a systems biology perspective. Mol Syst Biol. 2009;5:249. Epub 2009 Mar 17.
10.
Roukos DH. Mea Culpa with cancer-targeted therapy: new thinking and new agents design for novel, causal networks-based, personalized biomedicine. Expert Rev Mol Diagn. 2009;9(3):217–21.CrossRefPubMed
Metadata
Title
Targeting Gastric Cancer with Trastuzumab: New Clinical Practice and Innovative Developments to Overcome Resistance
Author
Dimitrios H. Roukos, MD
Publication date
01-01-2010
Publisher
Springer-Verlag
Published in
Annals of Surgical Oncology / Issue 1/2010
Print ISSN: 1068-9265
Electronic ISSN: 1534-4681
DOI
https://doi.org/10.1245/s10434-009-0766-0

Other articles of this Issue 1/2010

Annals of Surgical Oncology 1/2010 Go to the issue

Gastrointestinal Oncology

Follow-Up Strategy After Curative Resection of Gastric Cancer: A Nationwide Survey in Korea

Breast Oncology

Prognostic Impact of [18F] FDG-PET in Operable Breast Cancer Treated with Neoadjuvant Chemotherapy

Breast Oncology

The Effects of Additional Tumor Cavity Sampling at the Time of Breast-Conserving Surgery on Final Margin Status, Volume of Resection, and Pathologist Workload

Bone and Soft Tissue Sarcomas

Perioperative Hyperfractionated High-Dose Rate Brachytherapy for the Treatment of Soft Tissue Sarcomas: Multicentric Experience

Endocrine Tumors

RET Germline Mutations in Codon 609 and MEN2A Phenotype: Are They All Created Equal?

Breast Oncology

Intra-Individual Comparison of Lymphatic Drainage Patterns Using Subareolar and Peritumoral Isotope Injection for Breast Cancer