Published in:
27-01-2024 | Thrombotic Thrombocytopenic Purpura | Research
Largest comparison between onset and relapses of acquired thrombotic thrombocytopenic purpura reveals severe neurological involvement and worse analytic parameters at debut
Authors:
Blanca Vegas Villalmanzo, Rodrigo Cantera Estefanía, Sara Muñoz Madrid, Mariana Cerrato Salas, Irene Arnaiz Martín, Marta Molina Pérez, Beatriz Sagrista López, Yolanda Ruiz Ramírez, Javier Cucharero Martín, Pablo Estival Monteliú, Paloma Ropero Gradilla, Sara Ferrer Benito, María Paz Martín Hernández, Fernando Ataulfo González Fernández, Miguel Gómez Álvarez, Ana Villegas Martínez, Celina Benavente Cuesta, Jorge Martínez Nieto
Published in:
Annals of Hematology
|
Issue 3/2024
Login to get access
Abstract
It has been proposed that the onset of Acquired Thrombotic Thrombocytopenic Purpura (iTTP) is more severe than subsequent relapses; however, existing studies have limitations. We conducted a retrospective observational study to compare analytical and clinical severity of onset and relapse aTTP cases between 2012 and 2023. A total of 370 episodes of aTTP were analyzed, comprising 272 at initial diagnosis and 98 relapses. At onset, analytical parameters indicative of severity (low hemoglobin, low platelet count, and increased LDH) were significantly worse; patients had severe neurological symptoms (p<0.001) and ≥ 3 points in the TMA mortality score (p<0.001). In conclusion, the onset of aTTP is associated with worse analytical parameters and severe neurological involvement.