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Indian Journal of Hematology and Blood Transfusion

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08-11-2022 | Thrombocytopenia | Original Article

The Usability of Platelet Mass Index Thresholds to Assess the Repeated Platelet Transfusion Requirements in Neonates

Authors: Asli Okbay Gunes, Suleyman Geter, Mehmet Emin Avlanmis

Published in: Indian Journal of Hematology and Blood Transfusion | Issue 3/2023

Abstract

To evaluate the usability of platelet mass index (PMI) thresholds to assess the repeated platelet transfusion requirements in neonates who have received transfusion within the previous six days. This is a retrospective cross-sectional study conducted with neonates who received prophylactic platelet transfusion. The PMI was calculated as platelet count (× 1000/mm3) × mean platelet volume (MPV) (fL). Platelet transfusions were divided into two groups as first (Group 1) and repeated transfusions (Group 2). The increment and percentage of increment in platelet counts, MPV and PMI after transfusion were compared between the two groups. The amounts of changes were calculated as: (Post-transfusion) − (Pre-transfusion values). The percentages of changes were calculated as: ([Post-transfusion − Pre-transfusion values]/Pre-tansfusion values) × 100. Eighty three platelet transfusions were analyzed in 28 neonates. The median gestational age and birth weight were 34.5 (26–37) weeks, and 2225 (752.5–2937.5) grams, respectively. There were 20 (24.1%) transfusions in Group 1, and 63 (75.9%) transfusions in Group 2. There were no differences in the amounts of changes in platelet counts, MPV and PMI between the groups (p > 0.05). When the percentages of changes were analyzed, it was found that the platelet counts and PMI in Group 1 increased to a greater extent compared to Group 2 (p = 0.026, p = 0.039, respectively), but no significant difference was found in MPV between the groups (p = 0.081). The lower percentage of change in PMI in Group 2 was associated with the lower percentage of change in platelet counts. Being transfused with adult platelets did not affect platelet volume of the neonates. Therefore, PMI thresholds can be used in neonates with a history of platelet transfusion.

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Title: The Usability of Platelet Mass Index Thresholds to Assess the Repeated Platelet Transfusion Requirements in Neonates
Authors: Asli Okbay Gunes
Suleyman Geter
Mehmet Emin Avlanmis
Publication date: 08-11-2022
Publisher: Springer India
Keywords: Thrombocytopenia
Platelet Transfusion
Published in: Indian Journal of Hematology and Blood Transfusion / Issue 3/2023
Print ISSN: 0971-4502
Electronic ISSN: 0974-0449
DOI: https://doi.org/10.1007/s12288-022-01604-3

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