Thirteen years’ experience in fertility preservation for cancer patients after in vitro fertilization and in vitro maturation treatments

Comparatively with IVM-FP, IVF-FP had a higher median [25th–75th percentile] number of oocytes collected—12 [8–18] vs 7 [5–13]; oocytes cryopreserved—10 [6–15] vs 5 [2–8]; and, where applicable, embryos cryopreserved—5 [3–7] vs 3 [2–5] (p < 0.000001). Following FP treatment, 32 patients (9.0%) died, 18 patients (5.6%) conceived spontaneously, and 23 patients (6.5%) returned to attempt pregnancy with a median lapse of returning of 4.6 [3.1–6.1] years. Of these, cryopreserved oocytes or embryos were used in 33 cycles (19 after IVF-FP and 14 after IVM-FP). Overall, the cumulative pregnancy rate (CPR) was 47.6% (10/21) and the live birth rate (LBR) was 38.1% (8/21). Per cycle, CPR and LBR were 37 and 31% following IVF-FP and 14 and 7% following IVM-FP, although these differences did not reach statistical significance. We report the fourth live birth after IVM-FP in cancer, and the first one after IVM embryo warming resulting from in vivo oocyte retrieval and IVM procedure.