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Journal of Assisted Reproduction and Genetics

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01-04-2018 | Assisted Reproduction Technologies

Low versus high volume of culture medium during embryo transfer: a randomized clinical trial

Authors: George Α. Sigalos, Yannis Michalopoulos, Athanasios G. Kastoras, Olga Triantafyllidou, Nikos F. Vlahos

Published in: Journal of Assisted Reproduction and Genetics | Issue 4/2018

Abstract

Purpose

The aim of this prospective randomized control trial was to evaluate if the use of two different volumes (20–25 vs 40–45 μl) of media used for embryo transfer affects the clinical outcomes in fresh in vitro fertilization (IVF) cycles.

Methods

In total, 236 patients were randomized in two groups, i.e., “low volume” group (n = 118) transferring the embryos with 20–25 μl of medium and “high volume” group (n = 118) transferring the embryos with 40–45 μl of medium. The clinical pregnancy, implantation, and ongoing pregnancy rates were compared between the two groups.

Results

No statistically significant differences were observed in clinical pregnancy (46.8 vs 54.3%, p = 0.27), implantation (23.7 vs 27.8%, p = 0.30), and ongoing pregnancy (33.3 vs 40.0%, p = 0.31) rates between low and high volume group, respectively.

Conclusion

Higher volume of culture medium to load the embryo into the catheter during embryo transfer does not influence the clinical outcome in fresh IVF cycles.

Trial registration number: NCT03350646

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Title: Low versus high volume of culture medium during embryo transfer: a randomized clinical trial
Authors: George Α. Sigalos
Yannis Michalopoulos
Athanasios G. Kastoras
Olga Triantafyllidou
Nikos F. Vlahos
Publication date: 01-04-2018
Publisher: Springer US
Published in: Journal of Assisted Reproduction and Genetics / Issue 4/2018
Print ISSN: 1058-0468
Electronic ISSN: 1573-7330
DOI: https://doi.org/10.1007/s10815-017-1099-8

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Low versus high volume of culture medium during embryo transfer: a randomized clinical trial

Abstract

Purpose

Methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusion

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