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Journal of Assisted Reproduction and Genetics

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01-04-2018 | Fertility Preservation

Ovarian tissue cryopreservation (OTC) in prepubertal girls and young women: an analysis of parents’ and patients’ decision-making

Authors: Chantae S. Sullivan-Pyke, Claire A. Carlson, Maureen Prewitt, Clarisa R. Gracia, Jill P. Ginsberg

Published in: Journal of Assisted Reproduction and Genetics | Issue 4/2018

Abstract

Purpose

The purpose of this study was to explore the decision-making influences, perceived level of control over decision-making, and mood states of parents and patients who were offered OTC prior to gonadotoxic therapy.

Methods

Parents and patients, at least 12 years old, who required gonadotoxic therapy and were offered OTC prior to therapy, were asked to complete questionnaires. Two validated instruments were also used: the Decision-Making Control Instrument (DMCI) and the Profile of Mood States (POMS). The factors that influenced decision-making were compared using Student’s t test, and the scores of DMCI and POMS were compared using the Mann-Whitney test.

Results

Thirty-six parents and 16 patients who elected ovarian tissue cryopreservation (OTC) completed questionnaires. Five parents who declined OTC also completed questionnaires. Accepters thought OTC was a good idea and that, in the future, science would enable cryopreserved ovarian tissue to be used to restore fertility (100% parents, 93.8% patients). Among accepters, the desire for genetically related children and prevention of the stress of infertility drove parents’ and patients’ decisions (90.9 and 100%, respectively). The desire to prevent the stress of infertility was important to parents, but patients were less likely to report that a desire to prevent the stress of infertility factored into their decision-making (66.7 vs. 50.0%; p < 0.001). All respondents felt in control of their decision and displayed low levels of mood disturbance.

Conclusions

Though the decision to undergo experimental OTC is difficult and often urgent, this study suggests that families feel in control of their decision-making and report little emotional disturbance.

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Title: Ovarian tissue cryopreservation (OTC) in prepubertal girls and young women: an analysis of parents’ and patients’ decision-making
Authors: Chantae S. Sullivan-Pyke
Claire A. Carlson
Maureen Prewitt
Clarisa R. Gracia
Jill P. Ginsberg
Publication date: 01-04-2018
Publisher: Springer US
Published in: Journal of Assisted Reproduction and Genetics / Issue 4/2018
Print ISSN: 1058-0468
Electronic ISSN: 1573-7330
DOI: https://doi.org/10.1007/s10815-018-1123-7

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Springer Medicine

Ovarian tissue cryopreservation (OTC) in prepubertal girls and young women: an analysis of parents’ and patients’ decision-making

Abstract

Purpose

Methods

Results

Conclusions

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Abstract

Purpose

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