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Osteoporosis International
Published in: Osteoporosis International 6/2009

Open Access 01-06-2009 | Bone Quality Seminars: Ultrastructure

The role of osteocytes in bone mechanotransduction

Authors: A. Santos, A. D. Bakker, J. Klein-Nulend

Published in: Osteoporosis International | Issue 6/2009

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Excerpt

Bones are subjected to a variety of mechanical loads during daily activities. In the nineteenth century, Julius Wolff proposed that bones adapt their mass and 3D structure to the loading conditions in order to optimize their load-bearing capacity, and that this process is driven by mechanical stress [1]. For the past centuries, an increasing number of theoretical and experimental results reveal that osteocytes are the pivotal cells orchestrating this biomechanical regulation of bone mass and structure, which is accomplished by the process of bone remodeling [2‐5] …
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Metadata
Title
The role of osteocytes in bone mechanotransduction
Authors
A. Santos
A. D. Bakker
J. Klein-Nulend
Publication date
01-06-2009
Publisher
Springer-Verlag
Published in
Osteoporosis International / Issue 6/2009
Print ISSN: 0937-941X
Electronic ISSN: 1433-2965
DOI
https://doi.org/10.1007/s00198-009-0858-5

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