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01-06-2009 | Original Article

High prevalence of vitamin K and D deficiency and decreased BMD in inflammatory bowel disease

Authors: A. Kuwabara, K. Tanaka, N. Tsugawa, H. Nakase, H. Tsuji, K. Shide, M. Kamao, T. Chiba, N. Inagaki, T. Okano, S. Kido

Published in: Osteoporosis International | Issue 6/2009

Abstract

Summary

Vitamin K and D deficiency and decreased bone mineral density (BMD) were highly prevalent in patients with inflammatory bowel disease (IBD), especially Crohn’s disease (CD). Dietary intakes of these vitamins, however, were above the Japanese adequate intakes in IBD patients, suggesting that malabsorption is the basis for hypovitaminosis K and D and decreased BMD.

Introduction

We have studied the possible involvement of vitamin K and D deficiency in the pathogenesis of decreased BMD in IBD.

Methods

Seventy patients with IBD were evaluated for their BMD; plasma levels of vitamin K; phylloquinone (PK), menaquinone-7 (MK-7), and 25OH-D; serum PTH, protein induced by vitamin K absence (PIVKA-II), and undercarboxylated osteocalcin (ucOC) levels; and their food intake.

Results

Compared with ulcerative colitis (UC) patients, CD patients had significantly lower plasma vitamin K and 25OH-D concentrations; significantly higher serum levels of PTH, PIVKA-II, and ucOC; and significantly lower BMD scores at almost all measurement sites. More IBD patients were vitamin K deficient in bone than in liver. Multiple regression analyses revealed that low plasma concentrations of vitamin K and 25OH-D were independent risk factors for low BMD and that they were associated with the patients’ fat intake, but not with their intake of these vitamins.

Conclusion

IBD patients have high prevalence of decreased BMD and vitamin K and D deficiency probably caused by malabsorption of these vitamins.

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Title: High prevalence of vitamin K and D deficiency and decreased BMD in inflammatory bowel disease
Authors: A. Kuwabara
K. Tanaka
N. Tsugawa
H. Nakase
H. Tsuji
K. Shide
M. Kamao
T. Chiba
N. Inagaki
T. Okano
S. Kido
Publication date: 01-06-2009
Publisher: Springer-Verlag
Published in: Osteoporosis International / Issue 6/2009
Print ISSN: 0937-941X
Electronic ISSN: 1433-2965
DOI: https://doi.org/10.1007/s00198-008-0764-2

At a glance: The STEP trials

Springer Medicine

High prevalence of vitamin K and D deficiency and decreased BMD in inflammatory bowel disease

Abstract

Summary

Introduction

Methods

Results

Conclusion

At a glance: The STEP trials

Springer Medicine

Abstract

Summary

Introduction

Methods

Results

Conclusion

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