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Journal of Cancer Research and Clinical Oncology
Published in: Journal of Cancer Research and Clinical Oncology 7/2019

01-07-2019 | Review – Cancer Research

The role of dietary phytochemicals in the carcinogenesis via the modulation of miRNA expression

Authors: Marek Samec, Alena Liskova, Peter Kubatka, Sona Uramova, Pavol Zubor, Samson Mathews Samuel, Anthony Zulli, Martin Pec, Tibor Bielik, Kamil Biringer, Erik Kudela, Jozef Benacka, Mariusz Adamek, Luis Rodrigo, Rachele Ciccocioppo, Taeg Kyu Kwon, Denis Baranenko, Peter Kruzliak, Dietrich Büsselberg

Published in: Journal of Cancer Research and Clinical Oncology | Issue 7/2019

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Abstract

Purpose

Phytochemicals are naturally occurring plant-derived compounds and some of them have the potential to serve as anticancer drugs. Based on recent evidence, aberrantly regulated expression of microRNAs (miRNAs) is closely associated with malignancy. MicroRNAs are characterized as small non-coding RNAs functioning as posttranscriptional regulators of gene expression. Accordingly, miRNAs regulate various target genes, some of which are involved in the process of carcinogenesis.

Results

This comprehensive review emphasizes the anticancer potential of phytochemicals, either isolated or in combination, mediated by miRNAs. The ability to modulate the expression of miRNAs demonstrates their importance as regulators of tumorigenesis. Phytochemicals as anticancer agents targeting miRNAs are widely studied in preclinical in vitro and in vivo research. Unfortunately, their anticancer efficacy in targeting miRNAs is less investigated in clinical research.

Conclusions

Significant anticancer properties of phytochemicals as regulators of miRNA expression have been proven, but more studies investigating their clinical relevance are needed.
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Metadata
Title
The role of dietary phytochemicals in the carcinogenesis via the modulation of miRNA expression
Authors
Marek Samec
Alena Liskova
Peter Kubatka
Sona Uramova
Pavol Zubor
Samson Mathews Samuel
Anthony Zulli
Martin Pec
Tibor Bielik
Kamil Biringer
Erik Kudela
Jozef Benacka
Mariusz Adamek
Luis Rodrigo
Rachele Ciccocioppo
Taeg Kyu Kwon
Denis Baranenko
Peter Kruzliak
Dietrich Büsselberg
Publication date
01-07-2019
Publisher
Springer Berlin Heidelberg
Published in
Journal of Cancer Research and Clinical Oncology / Issue 7/2019
Print ISSN: 0171-5216
Electronic ISSN: 1432-1335
DOI
https://doi.org/10.1007/s00432-019-02940-0

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