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Breast Cancer Research
Published in: Breast Cancer Research 1/2015

Open Access 01-12-2015 | Review

Dysregulation of microRNAs in breast cancer and their potential role as prognostic and predictive biomarkers in patient management

Authors: Eleni van Schooneveld, Hans Wildiers, Ignace Vergote, Peter B Vermeulen, Luc Y Dirix, Steven J Van Laere

Published in: Breast Cancer Research | Issue 1/2015

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Abstract

MicroRNAs (miRNAs) are an emerging class of gene expression modulators with relevant roles in several biological processes, including cell differentiation, development, apoptosis, and regulation of the cell cycle. Deregulation of those tiny RNA molecules has been described frequently as a major determinant for the initiation and progression of diseases, including cancer. Not only miRNAs but also the enzymes responsible for miRNA processing could be deregulated in cancer. In this review, we address the role of miRNAs in the pathogenesis of breast cancer, since there are oncogenic, tumor-suppressive, and metastatic-influencing miRNAs. Additionally, the different detection platforms and normalization strategies for miRNAs will be discussed. The major part of this review, however, will focus on the capability of miRNAs to act as diagnostic, predictive, or prognostic biomarkers. We will give an overview of their potential to correlate with response to or benefit from a given treatment and we will consider their ability to give information on prognosis in breast cancer. We will focus on miRNAs validated by more than one study or verified in independent cohorts or where results rely on preclinical as well as clinical evidence. As such, we will discuss their potential use in the personalized management of breast cancer.
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Metadata
Title
Dysregulation of microRNAs in breast cancer and their potential role as prognostic and predictive biomarkers in patient management
Authors
Eleni van Schooneveld
Hans Wildiers
Ignace Vergote
Peter B Vermeulen
Luc Y Dirix
Steven J Van Laere
Publication date
01-12-2015
Publisher
BioMed Central
Published in
Breast Cancer Research / Issue 1/2015
Electronic ISSN: 1465-542X
DOI
https://doi.org/10.1186/s13058-015-0526-y

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