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Endocrine
Published in: Endocrine 1/2017

01-01-2017 | Original Article

The prevalence and determinants of hypothyroidism in hospitalized patients with type 2 diabetes mellitus

Authors: Fei Song, Cuiping Bao, Meiyu Deng, Hui Xu, Meijuan Fan, Stéphanie Paillard-Borg, Weili Xu, Xiuying Qi

Published in: Endocrine | Issue 1/2017

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Abstract

The purpose of this study was to investigate the prevalence of hypothyroidism among hospitalized patients with type 2 diabetes mellitus and its related factors, and to assess the prevalence of macrovascular and microvascular diseases among type 2 diabetes mellitus inpatients with hypothyroidism and euthyroidism. A total of 1662 type 2 diabetes mellitus inpatients hospitalized at the Metabolic Diseases Hospital, Tianjin Medical University from 1 January 2008 to 1 March 2013 were included in this study. Information on demographic and anthropometric factors and additional variables related to hypothyroidism were collected from medical records. Prevalence rates were calculated and standardized using direct method based on the age-specific and sex-specific structure of all participants. Data were analyzed using binary logistic regression with adjustment for potential confounders. The prevalence of hypothyroidism among type 2 diabetes mellitus inpatients was 6.8 %, and 77.0 % of the patients with hypothyroidism had subclinical hypothyroidism. The prevalence of hypothyroidism increased with age, and was higher in women (10.8 %) than in men (3.4 %). Older age (odds ratio, 1.74; 95 % confidence interval, 1. 05 to 2.89), female gender (odds ratio, 2.02; 95 % confidence interval, 1.05 to 3.87), and positive thyroid peroxidase antibody (odds ratio, 4.99; 95 % confidence interval, 2.83 to 8.79) were associated with higher odds of hypothyroidism among type 2 diabetes mellitus inpatients. The type 2 diabetes mellitus inpatients with hypothyroidism had higher prevalence of cerebrovascular diseases than those with euthyroidism after adjustment for age and gender. The prevalence of hypothyroidism among type 2 diabetes mellitus inpatients was 6.8 %, and most patients had subclinical hypothyroidism. Older age, female gender, and positive thyroid peroxidase antibody could be indicators for detecting hypothyroidism in type 2 diabetes mellitus inpatients.
Literature
1.
2.
3.
S.M. Ghazali, F.M. Abbiyesuku, Thyroid dysfunction in type 2 diabetics seen at the University College Hospital, Ibadan, Nigeria. Niger. J. Physiol. Sci. 25(2), 173–179 (2010)PubMed
4.
B. Song, Thyroid diaease epidemiology among Nanjing community population (article in Chinese). Master's Thesis, Nanjing Medical University (2011)
5.
G.J. Canaris, N.R. Manowitz, G. Mayor, E.C. Ridgway, The Colorado thyroid disease prevalence study. Arch. Int. Med. 160(4), 526–534 (2000)CrossRef
6.
N. Knudsen, T. Jorgensen, S. Rasmussen, E. Christiansen, H. Perrild, The prevalence of thyroid dysfunction in a population with borderline iodine deficiency. Clin. Endocrinol. 51(3), 361–367 (1999)CrossRef
7.
H.E. Tamez-Perez, E. Martinez, D.L. Quintanilla-Flores, A.L. Tamez-Pena, H. Gutierrez-Hermosillo, E. Diaz de Leon-Gonzalez, The rate of primary hypothyroidism in diabetic patients is greater than in the non-diabetic population. An observational study. Med. Clin. 138(11), 475–477 (2012). doi:10.​1016/​j.​medcli.​2011.​08.​009 CrossRef
8.
9.
R. Zhao, A preliminary study on the function of thyroid in patients with type 2 diabetes (article in Chinese). Master's Thesis, Ningxia Medical University (2013)
10.
M. Al-Geffari, N.A. Ahmad, A.H. Al-Sharqawi, A.M. Youssef, D. Alnaqeb, K. Al-Rubeaan, Risk factors for thyroid dysfunction among type 2 diabetic patients in a highly diabetes mellitus prevalent society. Int. J. Endocrinol. 2013, 417920 (2013). doi:10.​1155/​2013/​417920 CrossRefPubMedPubMedCentral
11.
G. Chen, J. Wu, Y. Lin, B. Huang, J. Yao, Q. Jiang, J. Wen, L. Lin, Associations between cardiovascular risk, insulin resistance, beta-cell function and thyroid dysfunction: a cross-sectional study in She ethnic minority group of Fujian Province in China. Eur. J. Endocrinol. 163(5), 775–782 (2010). doi:10.​1530/​EJE-10-0710 CrossRefPubMed
12.
J.J. Diez, P. Iglesias, Spontaneous subclinical hypothyroidism in patients older than 55 years: an analysis of natural course and risk factors for the development of overt thyroid failure. J. Clin. Endocrinol. Metab. 89(10), 4890–4897 (2004). doi:10.​1210/​jc.​2003-032061 CrossRefPubMed
13.
14.
A. Ishay, I. Chertok-Shaham, I. Lavi, R. Luboshitzky, Prevalence of subclinical hypothyroidism in women with type 2 diabetes. Med. Sci. Monit. 15(4), CR151–155 (2009)PubMed
15.
16.
W.T. Friedewald, R.I. Levy, D.S. Fredrickson, Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin. Chem. 18(6), 499–502 (1972)PubMed
17.
Chinese Medical Association Endocrinology Branch, Throid disease diagnosis and treatment guidelines --- Hypothyroidism (article in Chinese). J. Intern. Med. 46, 967–971 (2007)
18.
19.
20.
21.
D. Zhang, L. Zhang, Y. Zhang, et al., Association of subclinical hypothyroidism with diabetic chronic complications in type 2 diabetic patients (article in Chinese). Chin. J. Diabetes (2014)
22.
23.
A. Moura Neto, M.C. Parisi, S.M. Alegre, E.J. Pavin, M.A. Tambascia, D.E. Zantut-Wittmann, Relation of thyroid hormone abnormalities with subclinical inflammatory activity in patients with type 1 and type 2 diabetes mellitus. Endocrine 51(1), 63–71 (2016). doi:10.​1007/​s12020-015-0651-5 CrossRefPubMed
24.
25.
J. Xu, Y.H. Zhao, Y.P. Chen, X.L. Yuan, J. Wang, H. Zhu, C.M. Lu, Maternal circulating concentrations of tumor necrosis factor-alpha, leptin, and adiponectin in gestational diabetes mellitus: a systematic review and meta-analysis. Scientific World J. 2014, 926932 (2014). doi:10.​1155/​2014/​926932
26.
T.M. Ortiga-Carvalho, K.J. Oliveira, B.A. Soares, C.C. Pazos-Moura, The role of leptin in the regulation of TSH secretion in the fed state: in vivo and in vitro studies. J. Endocrinol. 174(1), 121–125 (2002)CrossRefPubMed
27.
P. Perros, R.J. McCrimmon, G. Shaw, B.M. Frier, Frequency of thyroid dysfunction in diabetic patients: value of annual screening. Diabetic Med. 12(7), 622–627 (1995)CrossRefPubMed
28.
J. Kvetny, P.E. Heldgaard, E.M. Bladbjerg, J. Gram, Subclinical hypothyroidism is associated with a low-grade inflammation, increased triglyceride levels and predicts cardiovascular disease in males below 50 years. Clin. Endocrinol. 61(2), 232–238 (2004). doi:10.​1111/​j.​1365-2265.​2004.​02088.​x CrossRef
29.
30.
F. Jia, J. Tian, F. Deng, G. Yang, M. Long, W. Cheng, B. Wang, J. Wu, D. Liu, Subclinical hypothyroidism and the associations with macrovascular complications and chronic kidney disease in patients with Type 2 diabetes. Diabetic Med. 32(8), 1097–1103 (2015). doi:10.​1111/​dme.​12724 CrossRefPubMed
31.
M. Suher, E. Koc, N. Ata, C. Ensari, Relation of thyroid disfunction, thyroid autoantibodies, and renal function. Renal Fail. 27(6), 739–742 (2005)CrossRef
32.
E. Guastamacchia, V. Triggiani, A. Aglialoro, A. Aiello, L. Ianni, M. Maccario, M. Zini, C. Giorda, R. Guglielmi, C. Betterle, R. Attanasio, G. Borretta, P. Garofalo, E. Papini, R. Castello, A. Ceriello, Italian Association of Clinical Endocrinologists (AME) & Italian Association of Clinical Diabetologists (AMD) position statement: diabetes mellitus and thyroid disorders: recommendations for clinical practice. Endocrine 49(2), 339–352 (2015). doi:10.​1007/​s12020-014-0474-9 CrossRefPubMed
33.
J.G. Hollowell, N.W. Staehling, W.D. Flanders, W.H. Hannon, E.W. Gunter, C.A. Spencer, L.E. Braverman, Serum TSH, T(4), and thyroid antibodies in the United States population (1988 to 1994): National Health and Nutrition Examination Survey (NHANES III). J. Clin. Endocrinol. Metab. 87(2), 489–499 (2002). doi:10.​1210/​jcem.​87.​2.​8182 CrossRefPubMed
34.
A.M. Michalek, M.C. Mahoney, D. Calebaugh, Hypothyroidism and diabetes mellitus in an American Indian population. J. Fam. Pract. 49(7), 638–640 (2000)PubMed
35.
A. Giandalia, G.T. Russo, E.L. Romeo, A. Alibrandi, P. Villari, A.A. Mirto, G. Armentano, S. Benvenga, D. Cucinotta, Influence of high-normal serum TSH levels on major cardiovascular risk factors and Visceral Adiposity Index in euthyroid type 2 diabetic subjects. Endocrine 47(1), 152–160 (2014). doi:10.​1007/​s12020-013-0137-2 CrossRefPubMed
36.
G.C. Gonzalez, I. Capel, J. Rodriguez-Espinosa, D. Mauricio, A. de Leiva, A. Perez, Thyroid autoimmunity at onset of type 1 diabetes as a predictor of thyroid dysfunction. Diabetes Care 30(6), 1611–1612 (2007). doi:10.​2337/​dc06-2595 CrossRefPubMed
37.
38.
39.
S. Furukawa, S. Yamamoto, Y. Todo, K. Maruyama, T. Miyake, T. Ueda, T. Niiya, T. Senba, M. Torisu, T. Kumagi, S. Miyauchi, T. Sakai, H. Minami, H. Miyaoka, B. Matsuura, Y. Hiasa, M. Onji, T. Tanigawa, Association between subclinical hypothyroidism and diabetic nephropathy in patients with type 2 diabetes mellitus. Endocrine J. 61(10), 1011–1018 (2014)CrossRef
40.
J. Lado-Abeal, Thyroid hormones are needed to sustain “inappropriately” normal TSH during non-thyroidal illness syndrome: a clinical observation in severely ill patients with primary hypothyroidism. Neuro Endocrinol. Lett. 36(1), 41–47 (2015)PubMed
41.
S. Khatiwada, B. Gelal, M.K. Tamang, R. Kc, S. Singh, M. Lamsal, N. Baral, Iodized salt use and salt iodine content among household salts from six districts of eastern Nepal. J. Nepal Health Res. Counc. 12(28), 191–194 (2014)PubMed
Metadata
Title
The prevalence and determinants of hypothyroidism in hospitalized patients with type 2 diabetes mellitus
Authors
Fei Song
Cuiping Bao
Meiyu Deng
Hui Xu
Meijuan Fan
Stéphanie Paillard-Borg
Weili Xu
Xiuying Qi
Publication date
01-01-2017
Publisher
Springer US
Published in
Endocrine / Issue 1/2017
Print ISSN: 1355-008X
Electronic ISSN: 1559-0100
DOI
https://doi.org/10.1007/s12020-016-1095-2

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