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Published in: Multidisciplinary Respiratory Medicine 1/2017

Open Access 01-12-2017 | Review

The physiological basis and clinical significance of lung volume measurements

Author: Mohamed Faisal Lutfi

Published in: Multidisciplinary Respiratory Medicine | Issue 1/2017

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Abstract

From a physiological standpoint, the lung volumes are either dynamic or static. Both subclasses are measured at different degrees of inspiration or expiration; however, dynamic lung volumes are characteristically dependent on the rate of air flow. The static lung volumes/capacities are further subdivided into four standard volumes (tidal, inspiratory reserve, expiratory reserve, and residual volumes) and four standard capacities (inspiratory, functional residual, vital and total lung capacities). The dynamic lung volumes are mostly derived from vital capacity. While dynamic lung volumes are essential for diagnosis and follow up of obstructive lung diseases, static lung volumes are equally important for evaluation of obstructive as well as restrictive ventilatory defects. This review intends to update the reader with the physiological basis, clinical significance and interpretative approaches of the standard static lung volumes and capacities.
Literature
2.
go back to reference Gerbase MW, Dupuis-Lozeron E, Schindler C, Keidel D, Bridevaux PO, Kriemler S, et al. Agreement between spirometers: a challenge in the follow-up of patients and populations? Respiration. 2013;85(6):505–14.CrossRefPubMed Gerbase MW, Dupuis-Lozeron E, Schindler C, Keidel D, Bridevaux PO, Kriemler S, et al. Agreement between spirometers: a challenge in the follow-up of patients and populations? Respiration. 2013;85(6):505–14.CrossRefPubMed
3.
go back to reference Liistro G, Vanwelde C, Vincken W, Vandevoorde J, Verleden G, Buffels J, et al. Technical and functional assessment of 10 office spirometers: A multicenter comparative study. Chest. 2006;130(3):657–65.CrossRefPubMed Liistro G, Vanwelde C, Vincken W, Vandevoorde J, Verleden G, Buffels J, et al. Technical and functional assessment of 10 office spirometers: A multicenter comparative study. Chest. 2006;130(3):657–65.CrossRefPubMed
5.
go back to reference Sue DY. Measurement of lung volumes in patients with obstructive lung disease. A matter of time (constants). Ann Am Thorac Soc. 2013;10(5):525–30.CrossRefPubMed Sue DY. Measurement of lung volumes in patients with obstructive lung disease. A matter of time (constants). Ann Am Thorac Soc. 2013;10(5):525–30.CrossRefPubMed
6.
go back to reference Swanney MP, Beckert LE, Frampton CM, Wallace LA, Jensen RL, Crapo RO. Validity of the American Thoracic Society and other spirometric algorithms using FVC and forced expiratory volume at 6s for predicting a reduced total lung capacity. Chest. 2004;126(6):1861–6.CrossRefPubMed Swanney MP, Beckert LE, Frampton CM, Wallace LA, Jensen RL, Crapo RO. Validity of the American Thoracic Society and other spirometric algorithms using FVC and forced expiratory volume at 6s for predicting a reduced total lung capacity. Chest. 2004;126(6):1861–6.CrossRefPubMed
9.
go back to reference Krowka MJ, Enright PL, Rodarte JR, Hyatt RE. Effect of Effort on Measurement of Forced Expiratory Volume in One Second. Am Rev Respir Dis. 1987;136(4):829–33.CrossRefPubMed Krowka MJ, Enright PL, Rodarte JR, Hyatt RE. Effect of Effort on Measurement of Forced Expiratory Volume in One Second. Am Rev Respir Dis. 1987;136(4):829–33.CrossRefPubMed
10.
go back to reference Sharafkhaneh A, Goodnight-White S, Officer TM, Rodarte JR, Boriek AM. Altered thoracic gas compression contributes to improvement in spirometry with lung volume reduction surgery. Thorax. 2005;60(4):288–92.CrossRefPubMedPubMedCentral Sharafkhaneh A, Goodnight-White S, Officer TM, Rodarte JR, Boriek AM. Altered thoracic gas compression contributes to improvement in spirometry with lung volume reduction surgery. Thorax. 2005;60(4):288–92.CrossRefPubMedPubMedCentral
11.
go back to reference Sharafkhaneh A, Babb TG, Officer TM, Hanania NA, Sharafkhaneh H, Boriek AM. The Confounding Effects of Thoracic Gas Compression on Measurement of Acute Bronchodilator Response. Am J Respir Crit Care Med. 2007;175(4):330–5.CrossRefPubMed Sharafkhaneh A, Babb TG, Officer TM, Hanania NA, Sharafkhaneh H, Boriek AM. The Confounding Effects of Thoracic Gas Compression on Measurement of Acute Bronchodilator Response. Am J Respir Crit Care Med. 2007;175(4):330–5.CrossRefPubMed
12.
go back to reference Milic-Emili J, Torchio R, D’Angelo E. Closing volume: a reappraisal (1967–2007). Eur J Appl Physiol. 2007;99(6):567–83.CrossRefPubMed Milic-Emili J, Torchio R, D’Angelo E. Closing volume: a reappraisal (1967–2007). Eur J Appl Physiol. 2007;99(6):567–83.CrossRefPubMed
23.
go back to reference Carey MA, Card JW, Voltz JW, Germolec DR, Korach KS, Zeldin DC. The impact of sex and sex hormones on lung physiology and disease: lessons from animal studies. Am J Physiol Lung Cell Mol Physiol. 2007;293(2):L272–8. Carey MA, Card JW, Voltz JW, Germolec DR, Korach KS, Zeldin DC. The impact of sex and sex hormones on lung physiology and disease: lessons from animal studies. Am J Physiol Lung Cell Mol Physiol. 2007;293(2):L272–8. 
25.
26.
go back to reference Jones RL, Nzekwu M-MU. The effects of body mass index on lung volumes. Chest. 2006;130(3):827–33.CrossRefPubMed Jones RL, Nzekwu M-MU. The effects of body mass index on lung volumes. Chest. 2006;130(3):827–33.CrossRefPubMed
27.
go back to reference Zavorsky GS, Murias JM, Kim DJ, Gow J, Sylvestre J-L, Christou NV. Waist-to-Hip Ratio Is Associated With Pulmonary Gas Exchange in the Morbidly Obese. Chest. 2007;131(2):362–7. Zavorsky GS, Murias JM, Kim DJ, Gow J, Sylvestre J-L, Christou NV. Waist-to-Hip Ratio Is Associated With Pulmonary Gas Exchange in the Morbidly Obese. Chest. 2007;131(2):362–7. 
28.
29.
go back to reference Myrianthefs P, Grammatopoulou I, Katsoulas T, Baltopoulos G. Spirometry may underestimate airway obstruction in professional Greek athletes. Clin Respir J. 2014;8(2):240–7.CrossRefPubMed Myrianthefs P, Grammatopoulou I, Katsoulas T, Baltopoulos G. Spirometry may underestimate airway obstruction in professional Greek athletes. Clin Respir J. 2014;8(2):240–7.CrossRefPubMed
30.
go back to reference Myrianthefs P, Baltopoulos G. A higher tidal volume may be used for athletes according to measured FVC. Scientific World Journal. 2013;2013:526138. doi:10.1155/2013/526138. Myrianthefs P, Baltopoulos G. A higher tidal volume may be used for athletes according to measured FVC. Scientific World Journal. 2013;2013:526138. doi:10.​1155/​2013/​526138.
32.
go back to reference Rong C, Bei H, Yun M, Yuzhu W, Mingwu Z. Lung function and cytokine levels in professional athletes. J Asthma. 2008;45(4):343–8.CrossRefPubMed Rong C, Bei H, Yun M, Yuzhu W, Mingwu Z. Lung function and cytokine levels in professional athletes. J Asthma. 2008;45(4):343–8.CrossRefPubMed
33.
go back to reference Kamal R, Kesavachandran CN, Bihari V, Sathian B, Srivastava AK. Alterations in Lung Functions Based on BMI and Body Fat % Among Obese Indian Population at National Capital Region. Nepal J Epidemiol. 2015;5(2):470–9.PubMedPubMedCentral Kamal R, Kesavachandran CN, Bihari V, Sathian B, Srivastava AK. Alterations in Lung Functions Based on BMI and Body Fat % Among Obese Indian Population at National Capital Region. Nepal J Epidemiol. 2015;5(2):470–9.PubMedPubMedCentral
35.
go back to reference Korotzer B, Ong S, Hansen JE. Ethnic differences in pulmonary function in healthy nonsmoking Asian-Americans and European-Americans. Am J Respir Crit Care Med. 2000;161(4 Pt 1):1101–8.CrossRefPubMed Korotzer B, Ong S, Hansen JE. Ethnic differences in pulmonary function in healthy nonsmoking Asian-Americans and European-Americans. Am J Respir Crit Care Med. 2000;161(4 Pt 1):1101–8.CrossRefPubMed
37.
go back to reference Whittaker AL, Sutton AJ, Beardsmore CS. Are ethnic differences in lung function explained by chest size? Arch Dis Child Fetal Neonatal Ed. 2005;90(5):F423–8.CrossRefPubMedPubMedCentral Whittaker AL, Sutton AJ, Beardsmore CS. Are ethnic differences in lung function explained by chest size? Arch Dis Child Fetal Neonatal Ed. 2005;90(5):F423–8.CrossRefPubMedPubMedCentral
38.
go back to reference Quanjer PH, Stanojevic S, Cole TJ, Baur X, Hall GL, Culver BH, et al. Multi-ethnic reference values for spirometry for the 3–95-yr age range: the global lung function 2012 equations. Eur Respir J. 2012;40(6):1324–43. Quanjer PH, Stanojevic S, Cole TJ, Baur X, Hall GL, Culver BH, et al. Multi-ethnic reference values for spirometry for the 3–95-yr age range: the global lung function 2012 equations. Eur Respir J. 2012;40(6):1324–43. 
42.
go back to reference Melam GR, Buragadda S, Alhusaini A, Alghamdi MA, Alghamdi MS, Kaushal P. Effect of Different Positions on FVC and FEV1 Measurements of Asthmatic Patients. J Phys Ther Sci. 2014;26(4):591–3.CrossRefPubMedPubMedCentral Melam GR, Buragadda S, Alhusaini A, Alghamdi MA, Alghamdi MS, Kaushal P. Effect of Different Positions on FVC and FEV1 Measurements of Asthmatic Patients. J Phys Ther Sci. 2014;26(4):591–3.CrossRefPubMedPubMedCentral
45.
go back to reference LoMauro A, Aliverti A. Respiratory physiology of pregnancy: Physiology masterclass. Breathe (Sheff). 2015;11(4):297–301. LoMauro A, Aliverti A. Respiratory physiology of pregnancy: Physiology masterclass. Breathe (Sheff). 2015;11(4):297–301. 
46.
go back to reference Pellegrino R, Viegi G, Brusasco V, Crapo RO, Burgos F, Casaburi R, et al. Interpretative strategies for lung function tests. Eur Respir J. 2005;26(5):948–68. Pellegrino R, Viegi G, Brusasco V, Crapo RO, Burgos F, Casaburi R, et al. Interpretative strategies for lung function tests. Eur Respir J. 2005;26(5):948–68. 
47.
go back to reference Degens P, Merget R. Reference values for spirometry of the European Coal and Steel Community: time for change. Eur Respir J. 2008;31(3):687-8-9.CrossRefPubMed Degens P, Merget R. Reference values for spirometry of the European Coal and Steel Community: time for change. Eur Respir J. 2008;31(3):687-8-9.CrossRefPubMed
48.
go back to reference Miller MR, Quanjer PH, Swanney MP, Ruppel G, Enright PL. Interpreting lung function data using 80% predicted and fixed thresholds misclassifies more than 20% of patients. Chest. 2011;139(1):52–9.CrossRefPubMed Miller MR, Quanjer PH, Swanney MP, Ruppel G, Enright PL. Interpreting lung function data using 80% predicted and fixed thresholds misclassifies more than 20% of patients. Chest. 2011;139(1):52–9.CrossRefPubMed
49.
go back to reference Mannino DM, Diaz-Guzman E. Interpreting lung function data using 80% predicted and fixed thresholds identifies patients at increased risk of mortality. Chest. 2012;141(1):73–80. Mannino DM, Diaz-Guzman E. Interpreting lung function data using 80% predicted and fixed thresholds identifies patients at increased risk of mortality. Chest. 2012;141(1):73–80. 
50.
go back to reference Lutfi MF. Review Article Vital capacity derived spirometric measurements. Sudan Med J. 2012;48(1):86–100. Lutfi MF. Review Article Vital capacity derived spirometric measurements. Sudan Med J. 2012;48(1):86–100.
51.
go back to reference Venkateshiah SB, Ioachimescu OC, McCarthy K, Stoller JK. The utility of spirometry in diagnosing pulmonary restriction. Lung. 186(1):19–25. Venkateshiah SB, Ioachimescu OC, McCarthy K, Stoller JK. The utility of spirometry in diagnosing pulmonary restriction. Lung. 186(1):19–25. 
56.
go back to reference Vandevoorde J, Verbanck S, Schuermans D, Broekaert L, Devroey D, Kartounian J, et al. Forced vital capacity and forced expiratory volume in six seconds as predictors of reduced total lung capacity. Eur Respir J. 2008;31(2):391-5. Vandevoorde J, Verbanck S, Schuermans D, Broekaert L, Devroey D, Kartounian J, et al. Forced vital capacity and forced expiratory volume in six seconds as predictors of reduced total lung capacity. Eur Respir J. 2008;31(2):391-5.
57.
go back to reference Lin C-K, Lin C-C. Work of breathing and respiratory drive in obesity. Respirology. 2012;17(3):402–11. Lin C-K, Lin C-C. Work of breathing and respiratory drive in obesity. Respirology. 2012;17(3):402–11. 
65.
go back to reference Shin TR, Oh Y-M, Park JH, et al. The Prognostic Value of Residual Volume/Total Lung Capacity in Patients with Chronic Obstructive Pulmonary Disease. J Korean Med Sci. 2015;30(10):1459–65.CrossRefPubMedPubMedCentral Shin TR, Oh Y-M, Park JH, et al. The Prognostic Value of Residual Volume/Total Lung Capacity in Patients with Chronic Obstructive Pulmonary Disease. J Korean Med Sci. 2015;30(10):1459–65.CrossRefPubMedPubMedCentral
66.
go back to reference Celli BR, Decramer M, Lystig T, Kesten S, Tashkin DP. Longitudinal inspiratory capacity changes in chronic obstructive pulmonary disease. Respir Res. 2012;13:66.CrossRefPubMedPubMedCentral Celli BR, Decramer M, Lystig T, Kesten S, Tashkin DP. Longitudinal inspiratory capacity changes in chronic obstructive pulmonary disease. Respir Res. 2012;13:66.CrossRefPubMedPubMedCentral
67.
go back to reference French A, Balfe D, Mirocha JM, Falk JA, Mosenifar Z. The inspiratory capacity/total lung capacity ratio as a predictor of survival in an emphysematous phenotype of chronic obstructive pulmonary disease. Int J Chron Obstruct Pulmon Dis. 2015;10:1305–12.PubMedPubMedCentral French A, Balfe D, Mirocha JM, Falk JA, Mosenifar Z. The inspiratory capacity/total lung capacity ratio as a predictor of survival in an emphysematous phenotype of chronic obstructive pulmonary disease. Int J Chron Obstruct Pulmon Dis. 2015;10:1305–12.PubMedPubMedCentral
68.
go back to reference Yetkin O, Gunen H. Inspiratory capacity and forced expiratory volume in the first second in exacerbation of chronic obstructive pulmonary disease. Clin Respir J. 2008;2(1):36–40.CrossRefPubMed Yetkin O, Gunen H. Inspiratory capacity and forced expiratory volume in the first second in exacerbation of chronic obstructive pulmonary disease. Clin Respir J. 2008;2(1):36–40.CrossRefPubMed
69.
go back to reference Zaman M, Mahmood S, Altayeh A. Low inspiratory capacity to total lung capacity ratio is a risk factor for chronic obstructive pulmonary disease exacerbation. Am J Med Sci. 2010;339(5):411–4.CrossRefPubMed Zaman M, Mahmood S, Altayeh A. Low inspiratory capacity to total lung capacity ratio is a risk factor for chronic obstructive pulmonary disease exacerbation. Am J Med Sci. 2010;339(5):411–4.CrossRefPubMed
71.
go back to reference Yuan W, He X, Xu Q-F, Wang H-Y, Casaburi R. Increased difference between slow and forced vital capacity is associated with reduced exercise tolerance in COPD patients. BMC Pulm Med. 2014;14:16.CrossRefPubMedPubMedCentral Yuan W, He X, Xu Q-F, Wang H-Y, Casaburi R. Increased difference between slow and forced vital capacity is associated with reduced exercise tolerance in COPD patients. BMC Pulm Med. 2014;14:16.CrossRefPubMedPubMedCentral
72.
go back to reference Tantucci C, Guerini M, Boni E, Corda L, Pini L. Tidal airway closure during bronchoconstriction in asthma: usefulness of lung volume measurements. J Asthma. 2011;48(1):33–40.CrossRefPubMed Tantucci C, Guerini M, Boni E, Corda L, Pini L. Tidal airway closure during bronchoconstriction in asthma: usefulness of lung volume measurements. J Asthma. 2011;48(1):33–40.CrossRefPubMed
73.
go back to reference Pellegrino R, Antonelli A, Crimi E, Gulotta C, Torchio R, Dutto L, et al. Dependence of bronchoconstrictor and bronchodilator responses on thoracic gas compression volume. Respirology. 2014;19(7):1040–5. Pellegrino R, Antonelli A, Crimi E, Gulotta C, Torchio R, Dutto L, et al. Dependence of bronchoconstrictor and bronchodilator responses on thoracic gas compression volume. Respirology. 2014;19(7):1040–5. 
74.
go back to reference Pellegrino R, Crimi E, Gobbi A, Torchio R, Antonelli A, Gulotta C, et al. Severity grading of chronic obstructive pulmonary disease: the confounding effect of phenotype and thoracic gas compression. J Appl Physiol. 2015;118(7):796–802.CrossRefPubMed Pellegrino R, Crimi E, Gobbi A, Torchio R, Antonelli A, Gulotta C, et al. Severity grading of chronic obstructive pulmonary disease: the confounding effect of phenotype and thoracic gas compression. J Appl Physiol. 2015;118(7):796–802.CrossRefPubMed
78.
go back to reference Gardner ZS, Ruppel GL, Kaminsky DA. Grading the severity of obstruction in mixed obstructive-restrictive lung disease. Chest. 2011;140(3):598–603. Gardner ZS, Ruppel GL, Kaminsky DA. Grading the severity of obstruction in mixed obstructive-restrictive lung disease. Chest. 2011;140(3):598–603. 
79.
go back to reference Chevalier-Bidaud B, Gillet-Juvin K, Callens E, Chenu R, Graba S, Essalhi M, et al. Non specific pattern of lung function in a respiratory physiology unit: causes and prevalence: results of an observational cross-sectional and longitudinal study. BMC Pulm Med. 2014;14:148. Chevalier-Bidaud B, Gillet-Juvin K, Callens E, Chenu R, Graba S, Essalhi M, et al. Non specific pattern of lung function in a respiratory physiology unit: causes and prevalence: results of an observational cross-sectional and longitudinal study. BMC Pulm Med. 2014;14:148. 
80.
go back to reference Hyatt RE, Cowl CT, Bjoraker JA, Scanlon PD. Conditions associated with an abnormal nonspecific pattern of pulmonary function tests. Chest. 2009;135(2):419–24. Hyatt RE, Cowl CT, Bjoraker JA, Scanlon PD. Conditions associated with an abnormal nonspecific pattern of pulmonary function tests. Chest. 2009;135(2):419–24. 
81.
go back to reference Iyer VN, Schroeder DR, Parker KO, Hyatt RE, Scanlon PD. The nonspecific pulmonary function test: longitudinal follow-up and outcomes. Chest. 2011;139(4):878–86. Iyer VN, Schroeder DR, Parker KO, Hyatt RE, Scanlon PD. The nonspecific pulmonary function test: longitudinal follow-up and outcomes. Chest. 2011;139(4):878–86. 
Metadata
Title
The physiological basis and clinical significance of lung volume measurements
Author
Mohamed Faisal Lutfi
Publication date
01-12-2017
Publisher
BioMed Central
Published in
Multidisciplinary Respiratory Medicine / Issue 1/2017
Electronic ISSN: 2049-6958
DOI
https://doi.org/10.1186/s40248-017-0084-5

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