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Medical Oncology
Published in: Medical Oncology 11/2016

01-11-2016 | Original Paper

The novel miR-9501 inhibits cell proliferation, migration and activates apoptosis in non-small cell lung cancer

Authors: Yongyong Xi, Liang wang, Chengcao Sun, Cuili Yang, Feng Zhang, Dejia Li

Published in: Medical Oncology | Issue 11/2016

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Abstract

Accumulating evidences suggest that lots of microRNAs (miRNAs) play crucial roles in (patho-)physiological processes of lung cancer, including metastasis, drug-resistance or tumorigenesis. They mediate the progression of cell growth, migration and invasion by regulating the expression of special genes. MiRNA expression patterns could also serve as diagnostic/prognostic biomarkers. Cancer therapies mediated by miRNAs remain tremendous potential and challenges. Our previous small RNA-seq assay found that the novel miR-9501 was down-regulated in lung cancer tissues compared with adjacent non-cancer tissues. In this study, our results verified that miR-9501 was significantly down-regulated in lung cancer tissues and its expression levels were remarkably suppressed in non-small cell lung cancer cell lines. Then, we characterized and investigated the novel miR-9501 in A549 cells. Transient transfection of miR-9501 into cultured A549 cells led to remarkable decrease in cell proliferation, migration and increase apoptosis. These data demonstrated that miR-9501 might be a tumor suppressor for lung cancer therapy.
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Metadata
Title
The novel miR-9501 inhibits cell proliferation, migration and activates apoptosis in non-small cell lung cancer
Authors
Yongyong Xi
Liang wang
Chengcao Sun
Cuili Yang
Feng Zhang
Dejia Li
Publication date
01-11-2016
Publisher
Springer US
Published in
Medical Oncology / Issue 11/2016
Print ISSN: 1357-0560
Electronic ISSN: 1559-131X
DOI
https://doi.org/10.1007/s12032-016-0837-6

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