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Published in: Medical Oncology 11/2016

01-11-2016 | Original Paper

7SK small nuclear RNA transcription level down-regulates in human tumors and stem cells

Authors: Mozhgan Abasi, Zahra Bazi, Samira Mohammadi-Yeganeh, Masoud Soleimani, Vahid Haghpanah, Nosratollah Zargami, Hossein Ghanbarian

Published in: Medical Oncology | Issue 11/2016

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Abstract

The small nuclear noncoding RNA (snRNA) 7SK is a highly conserved noncoding RNA of 331 nucleotides in animals, which is present in a nuclear ribonucleoprotein complex with proteins such as methylphosphate capping enzyme (MePCE), hexamethylene bisacetamide-inducible proteins 1 and 2 (HEXIM1 and HEXIM2) and La-related protein 7 (Larp7). Regulating the activity of the positive transcription elongation factor b (P-TEFb) is the key function of 7SK noncoding RNA. Recently, we have shown that 7SK snRNA over-expression reduces human embryonic kidney 293T cell line viability. Here, we attempt to monitor the expression level of 7SK snRNA in different human cell lines and cancer tissues. Examination of 7SK transcription either in cell lines or in different malignant tissues including blood (CML), breast and colon showed that 7SK expression significantly down-regulated in cancer. Similar to human cancer tissues and cell lines, 7SK transcriptional level decreased in stem cells in comparison with differentiated cell types. In this regard, over-expression of 7SK snRNA might be a powerful tool for blocking cancer progression by controlling the activity of P-TEFb.
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Metadata
Title
7SK small nuclear RNA transcription level down-regulates in human tumors and stem cells
Authors
Mozhgan Abasi
Zahra Bazi
Samira Mohammadi-Yeganeh
Masoud Soleimani
Vahid Haghpanah
Nosratollah Zargami
Hossein Ghanbarian
Publication date
01-11-2016
Publisher
Springer US
Published in
Medical Oncology / Issue 11/2016
Print ISSN: 1357-0560
Electronic ISSN: 1559-131X
DOI
https://doi.org/10.1007/s12032-016-0841-x

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