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Journal of Translational Medicine
Published in: Journal of Translational Medicine 1/2014

Open Access 01-05-2014 | Poster presentation

The mitochondrial master regulator gene PGC1alpha in novel sporadic melanoma cell lines: correlations with BRAF mutational status

Authors: Gabriella Guida, Immacolata Maida, Anna Ferretta, Tiziana Cocco, Stefania Guida, Paola Zanna, Rossella Labarile, Letizia Porcelli, Amalia Azzariti, Stefania Tommasi, Anna Albano, Sabino Strippoli, Mari C Turpin Sevilla, Raffaele Filotico, Michele Guida

Published in: Journal of Translational Medicine | Special Issue 1/2014

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Excerpt

Metabolic reprogramming is commonly found in cancer but it is poorly understood in melanoma. Recent works [1, 2] provided new insights concerning molecular mechanisms involved in mitochondrial biogenesis of melanoma. This work aims to find possible correlations between pathways involved in the onset and progression of the disease in order to provide supporting information in this field. In particular we studied the behaviour of the mitochondrial master regulator gene PGC1alpha in novel sporadic melanoma cell lines and its relations with BRAF mutational status. …
Literature
1.
Haq R, Shoag J, Andreu-Perez P, Yokoyama S, Edelman H, Rowe GC, Frederick DT, Hurley AD, Nellore A, Kung AL, Wargo JA, Song JS, Fisher DE, Arany Z, Widlund HR: Oncogenic BRAF regulates oxidative metabolism via PGC1a and MITF. Cancer Cell. 2013, 23 (3): 302-315. 10.1016/j.ccr.2013.02.003.PubMedCentralCrossRefPubMed
2.
Vasquez F, Lim J-H, Chim H, Bhalia K, Girnun G, Pierce K, Clish CB, Granter SR, Widlund HR, Spiegelman BM, Puigserver P: PGC1a Expression Defines a Subset of Human Melanoma Tumors with Increased Mitochondrial Capacity and Resistance to Oxidative Stress. Cancer Cell. 2013, 23 (3): 287-301. 10.1016/j.ccr.2012.11.020.CrossRef
3.
Zanna P: Molecular characterization of novel melanoma cell lines. J Biol Regul Homeost Agents. 2011, 25 (2): 239-247.PubMed
4.
Zanna P, Maida I, Grieco C, Guida S, Turbin Sevilla MC, De Summa S, Tommasi S, Vena GA, Filotico R, Guida G: Three novel human sporadic melanoma cell lines: signaling pathways controlled by MC1R, BRAF and ßcatenin. J Biol Regul Homeost Agents. 2013, 27 (1): 131-141.PubMed
Metadata
Title
The mitochondrial master regulator gene PGC1alpha in novel sporadic melanoma cell lines: correlations with BRAF mutational status
Authors
Gabriella Guida
Immacolata Maida
Anna Ferretta
Tiziana Cocco
Stefania Guida
Paola Zanna
Rossella Labarile
Letizia Porcelli
Amalia Azzariti
Stefania Tommasi
Anna Albano
Sabino Strippoli
Mari C Turpin Sevilla
Raffaele Filotico
Michele Guida
Publication date
01-05-2014
Publisher
BioMed Central
Published in
Journal of Translational Medicine / Issue Special Issue 1/2014
Electronic ISSN: 1479-5876
DOI
https://doi.org/10.1186/1479-5876-12-S1-P9

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Live Webinar | 27-06-2024 | 18:00 (CEST)

Keynote webinar | Spotlight on medication adherence

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Live: Thursday 27th June 2024, 18:00-19:30 (CEST)

WHO estimates that half of all patients worldwide are non-adherent to their prescribed medication. The consequences of poor adherence can be catastrophic, on both the individual and population level.

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Developed by: Springer Medicine
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