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Journal of Translational Medicine
Published in: Journal of Translational Medicine 1/2014

Open Access 01-05-2014 | Poster presentation

Phase Ib/II, open-label, dose-escalation study of LGX818, an oral selective BRAF inhibitor, in combination with MEK162, an oral MEK1/2 inhibitor, in patients with BRAF V600-dependent advanced solid tumors: preliminary results

Authors: Richard Kefford, Ryan J Sullivan, Wilson H Miller Jr, Elena M Elez, Daniel Tan, Kevin B Kim, Georgina V Long, Keith T Flaherty, David Tai, Simone Stutvoet, Heiko Maacke, Matt Whiley, Laure Moutouh-de Parseval, Josep Tabernero

Published in: Journal of Translational Medicine | Special Issue 1/2014

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Excerpt

Preclinical and clinical data suggest that combination of a BRAF and a MEK inhibitor (BRAFi, MEKi) may increase the efficacy over BRAFi monotherapy in BRAF-mutant metastatic melanoma and that addition of a MEKi may overcome or delay resistance to BRAFi. …
Metadata
Title
Phase Ib/II, open-label, dose-escalation study of LGX818, an oral selective BRAF inhibitor, in combination with MEK162, an oral MEK1/2 inhibitor, in patients with BRAF V600-dependent advanced solid tumors: preliminary results
Authors
Richard Kefford
Ryan J Sullivan
Wilson H Miller Jr
Elena M Elez
Daniel Tan
Kevin B Kim
Georgina V Long
Keith T Flaherty
David Tai
Simone Stutvoet
Heiko Maacke
Matt Whiley
Laure Moutouh-de Parseval
Josep Tabernero
Publication date
01-05-2014
Publisher
BioMed Central
Published in
Journal of Translational Medicine / Issue Special Issue 1/2014
Electronic ISSN: 1479-5876
DOI
https://doi.org/10.1186/1479-5876-12-S1-P5

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At a glance: The STEP trials

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A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.

Developed by: Springer Medicine

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