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Journal of Assisted Reproduction and Genetics
Published in: Journal of Assisted Reproduction and Genetics 8/2009

01-08-2009 | Assisted Reproduction

The influence of early cleavage on embryo developmental potential and IVF/ICSI outcome

Authors: Jing Fu, Xian-Jing Wang, Yong-Wei Wang, Jian Sun, Kristina Gemzell-Danielsson, Xiao-Xi Sun

Published in: Journal of Assisted Reproduction and Genetics | Issue 8/2009

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Abstract

Purpose

To observe whether early cleavage can be a predictor of embryo developmental potential, pregnancy and implantation rates.

Methods

A total of 9,544 embryos in 1,095 in vitro fertilization or intracytoplasmic sperm injection cycles were observed with regard to the appearance of early cleavage at 25–29 h post-insemination.

Results

A significantly higher proportion of excellent quality embryos were observed in the early cleavage group compared to the late cleavage group (52.5 versus 28.9%, P < 0.01). In the early cleavage group there was also a higher rate of pregnancy per transfer compared with the late cleavage group (38.7 versus 26.3%, P < 0.01). In addition, we found that transfer of only one early cleavage embryo resulted in a high pregnancy rate (38.5%) and a low multiple pregnancy rate (18.0%).

Conclusion

Early cleavage is a strong indicator of embryo quality, and may be used as an additional criterion in the selection of embryos for transfer to increase pregnancy rate and reduce multiple pregnancy rate.
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Metadata
Title
The influence of early cleavage on embryo developmental potential and IVF/ICSI outcome
Authors
Jing Fu
Xian-Jing Wang
Yong-Wei Wang
Jian Sun
Kristina Gemzell-Danielsson
Xiao-Xi Sun
Publication date
01-08-2009
Publisher
Springer US
Published in
Journal of Assisted Reproduction and Genetics / Issue 8/2009
Print ISSN: 1058-0468
Electronic ISSN: 1573-7330
DOI
https://doi.org/10.1007/s10815-009-9342-6

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