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Open Access 01-12-2013 | Research

The estimation of metaloproteinases and their inhibitors blood levels in patients with pancreatic tumors

Authors: Jacek Śmigielski, Łukasz Piskorz, Renata Talar -Wojnarowska, Ewa Malecka-Panas, Sławomir Jabłoński, Marian Brocki

Published in: World Journal of Surgical Oncology | Issue 1/2013

Abstract

Background

The aim of the study was to evaluate the concentration of proteolytic enzymes, MMP-2 and MMP-9, and their tissue inhibitors, TIMP-1 and TIMP-2, in the blood of patients with benign and malignant pancreatic tumors.

Methods

MMP-2, MMP-9, TIMP-1, and TIMP-2 were evaluated in the patients with benign and malignant pancreatic tumors before surgery and in the 30-day follow-up. The study covered 134 patients aged 54 to 76 years, who were divided into groups by TNM staging.

Results

Before the operation, the highest mean concentration of MMP-2 was found in patients with unresectable cancer, whereas the highest level of MMP-9 was in patients with resectable cancer. The highest level of TIMP-1 was noted in patients with inflammatory tumors. In 1 month following the operation, the highest level of MMP-2 was also in patients with unresectable cancer and the highest level of TIMP-2 in patients with inflammatory tumors.

Conclusions

The evaluation of the level of the studied cytokines in the pancreatic tumor patients can be diagnostically significant in the differentiation of benign and malignant changes. The changes in the levels of the studied enzymes and their inhibitors can have a prognostic value in the clinical severity of pancreatic cancer.

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Title: The estimation of metaloproteinases and their inhibitors blood levels in patients with pancreatic tumors
Authors: Jacek Śmigielski
Łukasz Piskorz
Renata Talar -Wojnarowska
Ewa Malecka-Panas
Sławomir Jabłoński
Marian Brocki
Publication date: 01-12-2013
Publisher: BioMed Central
Published in: World Journal of Surgical Oncology / Issue 1/2013
Electronic ISSN: 1477-7819
DOI: https://doi.org/10.1186/1477-7819-11-137

Keynote webinar | Spotlight on medication adherence

Springer Medicine

The estimation of metaloproteinases and their inhibitors blood levels in patients with pancreatic tumors

Abstract

Background

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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