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Diseases of the Colon & Rectum
Published in: Diseases of the Colon & Rectum 10/2004

01-10-2004 | Original Contributions

Systemic and Peritoneal Angiogenic Response After Laparoscopic or Conventional Colon Resection in Cancer Patients: A Prospective, Randomized Trial

Authors: F. P. K. Wu, M.D., K. Hoekman, M.D., Ph.D., C. Sietses, M.D., Ph.D., B. M. E. von Blomberg, Ph.D., S. Meijer, M.D., Ph.D., H. J. Bonjer, M.D., Ph.D., M. A. Cuesta, M.D., Ph.D.

Published in: Diseases of the Colon & Rectum | Issue 10/2004

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PURPOSE

Angiogenesis is essential for wound healing. Vascular endothelial growth factor and endostatin are both endogenous angiogenic factors thought to be involved in the initiation and termination of angiogenesis. The aim of this study was to assess the local and systemic angiogenic profile in patients undergoing laparoscopic or open surgery for colon cancer.

METHODS

Patients with primary colon carcinoma were prospectively randomized to curative laparoscopic (n = 12) or conventional (n = 14) resection. Vascular endothelial growth factor and endostatin levels in serum and wound fluid were investigated.

RESULTS

In both groups vascular endothelial growth factor levels in wound fluid were significantly higher than postoperative serum levels, whereas endostatin levels in wound fluid were lower than serum levels and decreased progressively after surgery. The vascular endothelial growth factor levels in wound fluid measured at Day 4 were significantly higher in the laparoscopy group than in the laparotomy patients.

CONCLUSIONS

Wound healing is associated with a strong local increase in pro-angiogenic factors and a decrease in antiangiogenic factors. The investigation of locally produced factors offered greater insight into the process of angiogenesis during wound healing than could be acquired from the circulation.
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Metadata
Title
Systemic and Peritoneal Angiogenic Response After Laparoscopic or Conventional Colon Resection in Cancer Patients: A Prospective, Randomized Trial
Authors
F. P. K. Wu, M.D.
K. Hoekman, M.D., Ph.D.
C. Sietses, M.D., Ph.D.
B. M. E. von Blomberg, Ph.D.
S. Meijer, M.D., Ph.D.
H. J. Bonjer, M.D., Ph.D.
M. A. Cuesta, M.D., Ph.D.
Publication date
01-10-2004
Publisher
Springer-Verlag
Published in
Diseases of the Colon & Rectum / Issue 10/2004
Print ISSN: 0012-3706
Electronic ISSN: 1530-0358
DOI
https://doi.org/10.1007/s10350-004-0660-6

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