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European Journal of Nuclear Medicine and Molecular Imaging

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Open Access 01-05-2022 | Original Article

The effect of modern PET technology and techniques on the EANM paediatric dosage card

Authors: John Dickson, Uta Eberlein, Michael Lassmann

Published in: European Journal of Nuclear Medicine and Molecular Imaging | Issue 6/2022

Abstract

Aim

Recent advancements in PET technology have brought with it significant improvements in PET performance and image quality. In particular, the extension of the axial field of view of PET systems, and the introduction of semiconductor technology into the PET detector, initially for PET/MR, and more recently available long-field-of-view PET/CT systems (≥ 25 cm) have brought a step change improvement in the sensitivity of PET scanners. Given the requirement to limit paediatric doses, this increase in sensitivity is extremely welcome for the imaging of children and young people. This is even more relevant with PET/MR, where the lack of CT exposures brings further dose reduction benefits to this population. In this short article, we give some details around the benefits around new PET technology including PET/MR and its implications on the EANM paediatric dosage card.

Material and methods

Reflecting on EANM adult guidance on injected activities, and making reference to bed overlap and the concept of MBq.min bed⁻¹ kg⁻¹, we use published data on image quality from PET/MR systems to update the paediatric dosage card for PET/MR and extended axial field of view (≥ 25 cm) PET/CT systems. However, this communication does not cover the expansion of paediatric dosing for the half-body and total-body scanners that have recently come to market.

Results

In analogy to the existing EANM dosage card, new parameters for the EANM paediatric dosage card were developed (class B, baseline value: 10.7 MBq, minimum recommended activity 10 MBq). The recommended administered activities for the systems considered in this communication range from 11 MBq [¹⁸F]FDG for a child with a weight of 3 kg to 149 MBq [¹⁸F]FDG for a paediatric patient weight of 68 kg, assuming a scan of 3 min per bed position. The mean effective dose over all ages (1 year and older) is 2.85 mSv.

Conclusion

With this, recommendations for paediatric dosing are given for systems that have not been considered previously.

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Title: The effect of modern PET technology and techniques on the EANM paediatric dosage card
Authors: John Dickson
Uta Eberlein
Michael Lassmann
Publication date: 01-05-2022
Publisher: Springer Berlin Heidelberg
Published in: European Journal of Nuclear Medicine and Molecular Imaging / Issue 6/2022
Print ISSN: 1619-7070
Electronic ISSN: 1619-7089
DOI: https://doi.org/10.1007/s00259-021-05635-2

Keynote webinar | Spotlight on medication adherence

Springer Medicine

The effect of modern PET technology and techniques on the EANM paediatric dosage card

Abstract

Aim

Material and methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Aim

Material and methods

Results

Conclusion

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