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Journal of Cancer Research and Clinical Oncology

Published in:

Open Access 01-10-2018 | Review – Clinical Oncology

The clinical usefulness of optical coherence tomography during cancer interventions

Authors: Labrinus van Manen, Jouke Dijkstra, Claude Boccara, Emilie Benoit, Alexander L. Vahrmeijer, Michalina J. Gora, J. Sven D. Mieog

Published in: Journal of Cancer Research and Clinical Oncology | Issue 10/2018

Abstract

Introduction

Tumor detection and visualization plays a key role in the clinical workflow of a patient with suspected cancer, both in the diagnosis and treatment. Several optical imaging techniques have been evaluated for guidance during oncological interventions. Optical coherence tomography (OCT) is a technique which has been widely evaluated during the past decades. This review aims to determine the clinical usefulness of OCT during cancer interventions focussing on qualitative features, quantitative features and the diagnostic value of OCT.

Methods

A systematic literature search was performed for articles published before May 2018 using OCT in the field of surgical oncology. Based on these articles, an overview of the clinical usefulness of OCT was provided per tumor type.

Results

A total of 785 articles were revealed by our search, of which a total of 136 original articles were available for analysis, which formed the basis of this review. OCT is currently utilised for both preoperative diagnosis and intraoperative detection of skin, oral, lung, breast, hepatobiliary, gastrointestinal, urological, and gynaecological malignancies. It showed promising results in tumor detection on a microscopic level, especially using higher resolution imaging techniques, such as high-definition OCT and full-field OCT.

Conclusion

In the near future, OCT could be used as an additional tool during bronchoscopic or endoscopic interventions and could also be implemented in margin assessment during (laparoscopic) cancer surgery if a laparoscopic or handheld OCT device will be further developed to make routine clinical use possible.

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Title: The clinical usefulness of optical coherence tomography during cancer interventions
Authors: Labrinus van Manen
Jouke Dijkstra
Claude Boccara
Emilie Benoit
Alexander L. Vahrmeijer
Michalina J. Gora
J. Sven D. Mieog
Publication date: 01-10-2018
Publisher: Springer Berlin Heidelberg
Published in: Journal of Cancer Research and Clinical Oncology / Issue 10/2018
Print ISSN: 0171-5216
Electronic ISSN: 1432-1335
DOI: https://doi.org/10.1007/s00432-018-2690-9

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