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Journal of Endocrinological Investigation
Published in: Journal of Endocrinological Investigation 1/2018

01-01-2018 | Review

The association between circulating fetuin-A levels and type 2 diabetes mellitus risk: systematic review and meta-analysis of observational studies

Authors: F. Roshanzamir, M. Miraghajani, M. H. Rouhani, M. Mansourian, R. Ghiasvand, S. M. Safavi

Published in: Journal of Endocrinological Investigation | Issue 1/2018

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Abstract

Background and objective

Fetuin-A is a liver-derived circulating protein that is associated with insulin resistance and diabetes. The objective of this systematic review and meta-analysis of published observational studies was to investigate mean levels of fetuin-A in T2D patients and the relationship between blood fetuin-A levels and T2D risk.

Materials and methods

PubMed, Embase, Google Scholar, Web of Science, and The Cochrane Library were systematically searched for potential relevant studies up to 1 December 2016. Natural logarithm-transformed estimate risks, standard mean differences on the basis of Hedges’s adjusted g, and 95% confidence intervals (CIs) were calculated for all eligible studies and were combined to measure the pooled data using random-effects model.

Results

A total of 32 studies including 27 case–control and 5 cohort studies were included in the current study. Fetuin-A levels in T2D patients were significantly higher than control groups [Hedges’ g = 1.73, 95% CI (1.25–2.22), P < 0.001], with significant heterogeneity across studies (P < 0.001, I 2 = 98.46%). Findings from meta-analyses of cohort studies showed a statistically significant association between fetuin-A levels and T2D risk [rate ratio = 1.62, 95% CI (1.26–2.08), P < 0.001], with no significant heterogeneity (P = 0.10, I 2 = 46.06%).

Conclusion

We found a significant relationship between the fetuin-A levels with T2D risk. Although fetuin-A may be as a potential screening and prediction biomarker or a therapeutic target in T2D patients, further studies are required in this regard.
Appendix
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Metadata
Title
The association between circulating fetuin-A levels and type 2 diabetes mellitus risk: systematic review and meta-analysis of observational studies
Authors
F. Roshanzamir
M. Miraghajani
M. H. Rouhani
M. Mansourian
R. Ghiasvand
S. M. Safavi
Publication date
01-01-2018
Publisher
Springer International Publishing
Published in
Journal of Endocrinological Investigation / Issue 1/2018
Electronic ISSN: 1720-8386
DOI
https://doi.org/10.1007/s40618-017-0697-8

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WHO estimates that half of all patients worldwide are non-adherent to their prescribed medication. The consequences of poor adherence can be catastrophic, on both the individual and population level.

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