Skip to main content
Top
Published in: Digestive Diseases and Sciences 2/2024

06-01-2024 | Tarry Feces | DDS–SIRC Cooperative Conferences

Gentle Giant? Giant Gastric Solitary Peutz-Jeghers Polyp

Authors: F. M. Mongardini, L. Nazzaro, G. Fuschillo, A. D’Alelio, C. Gambardella, L. Docimo, A. Lauro, V. Landolfi

Published in: Digestive Diseases and Sciences | Issue 2/2024

Login to get access

Abstract

Solitary hamartomatous polyps with identical pathological features of the typical hamartomas of the Peutz-Jegher syndrome are extremely rare. These solitary lesions lack the associated intestinal polyposis, classic mucocutaneous pigmentation, and family history typifying the Peutz-Jegher syndrome. We describe the case of a 31-year-old woman with a giant solitary gastric hamartoma endoscopically diagnosed and laparoscopically resected.
Literature
1.
go back to reference Tacheci I, Kopacova M, Bures J. Peutz-Jeghers syndrome. Curr Opin Gastroenterol. 2021;37:245–254.CrossRefPubMed Tacheci I, Kopacova M, Bures J. Peutz-Jeghers syndrome. Curr Opin Gastroenterol. 2021;37:245–254.CrossRefPubMed
2.
go back to reference McGarrity TJ, Amos CI, Baker MJ. Peutz-Jeghers Syndrome. 2001 Feb 23 [updated 2021 Sep 2]. In: Adam MP, Mirzaa GM, Pagon RA, Wallace SE, Bean LJH, Gripp KW, Amemiya A, editors. GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle; 1993–2023. McGarrity TJ, Amos CI, Baker MJ. Peutz-Jeghers Syndrome. 2001 Feb 23 [updated 2021 Sep 2]. In: Adam MP, Mirzaa GM, Pagon RA, Wallace SE, Bean LJH, Gripp KW, Amemiya A, editors. GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle; 1993–2023.
3.
4.
go back to reference Endo K, Kawamura K, Murakami K et al. A case of jejunal solitary Peutz-Jeghers polyp with intussusception identified by double-balloon enteroscopy. Clin J Gastroenterol. 2020;13:1129–1135.CrossRefPubMed Endo K, Kawamura K, Murakami K et al. A case of jejunal solitary Peutz-Jeghers polyp with intussusception identified by double-balloon enteroscopy. Clin J Gastroenterol. 2020;13:1129–1135.CrossRefPubMed
5.
go back to reference Westerman AM, Wilson JH. Peutz-Jeghers syndrome: risks of a hereditary condition. Scand J Gastroenterol Suppl. 1999;230:64–70.CrossRefPubMed Westerman AM, Wilson JH. Peutz-Jeghers syndrome: risks of a hereditary condition. Scand J Gastroenterol Suppl. 1999;230:64–70.CrossRefPubMed
6.
go back to reference Klimkowski S, Ibrahim M, Ibarra Rovira JJ et al. Peutz-Jeghers syndrome and the role of imaging: pathophysiology, diagnosis, and associated cancers. Cancers (Basel). 2021;13:5121.CrossRefPubMedPubMedCentral Klimkowski S, Ibrahim M, Ibarra Rovira JJ et al. Peutz-Jeghers syndrome and the role of imaging: pathophysiology, diagnosis, and associated cancers. Cancers (Basel). 2021;13:5121.CrossRefPubMedPubMedCentral
7.
go back to reference Liu BL, Zhou H, Risech M et al. Solitary Peutz-Jeghers type polyp of jejunum with gastric fundic and antral gland lining mucosa: a case report and review of literature. Int J Surg Pathol. 2022;30:539–542.CrossRefPubMed Liu BL, Zhou H, Risech M et al. Solitary Peutz-Jeghers type polyp of jejunum with gastric fundic and antral gland lining mucosa: a case report and review of literature. Int J Surg Pathol. 2022;30:539–542.CrossRefPubMed
8.
go back to reference Beggs AD, Latchford AR, Vasen HFA et al. Peutz-Jeghers syndrome: a systematic review and recommendations for management. Gut. 2010;59:975–986.CrossRefPubMed Beggs AD, Latchford AR, Vasen HFA et al. Peutz-Jeghers syndrome: a systematic review and recommendations for management. Gut. 2010;59:975–986.CrossRefPubMed
9.
go back to reference Bai-Cang Z, Feng-Fan W, Gang Z et al. A giant and extensive solitary Peutz-Jeghers-type polyp in the antrum of stomach. Medicine (Baltimore). 2017;96:e8466.CrossRef Bai-Cang Z, Feng-Fan W, Gang Z et al. A giant and extensive solitary Peutz-Jeghers-type polyp in the antrum of stomach. Medicine (Baltimore). 2017;96:e8466.CrossRef
10.
go back to reference Sorinel L, Vlad P, Natalia V et al. Giant solitary gastric Peutz-Jeghers polyp mimicking a malignant gastric tumor: the largest described in literature. J Gastrointest Liver Dis. 2014;23:321–324.CrossRef Sorinel L, Vlad P, Natalia V et al. Giant solitary gastric Peutz-Jeghers polyp mimicking a malignant gastric tumor: the largest described in literature. J Gastrointest Liver Dis. 2014;23:321–324.CrossRef
11.
go back to reference Zalud R, Neumann F, Volsansky P et al. Duodenojejunal intussusception caused by a solitary Peutz-Jeghers type hamartomatous polyp. Int J Case Rep Images 2015;6:481.CrossRef Zalud R, Neumann F, Volsansky P et al. Duodenojejunal intussusception caused by a solitary Peutz-Jeghers type hamartomatous polyp. Int J Case Rep Images 2015;6:481.CrossRef
12.
go back to reference Hunt J, Tindal D. Solitary gastric Peutz-Jeghers polyp and angiolipoma presenting as acute haemorrhage. Aust N Z J Surg. 1996;66:713–715.CrossRefPubMed Hunt J, Tindal D. Solitary gastric Peutz-Jeghers polyp and angiolipoma presenting as acute haemorrhage. Aust N Z J Surg. 1996;66:713–715.CrossRefPubMed
13.
14.
go back to reference Harbaum L, Geigl JB, Volkholz H et al. Sporadic gastric Peutz-Jeghers polyp with intraepithelial neoplasia. APMIS. 2009;117:941–943.CrossRefPubMed Harbaum L, Geigl JB, Volkholz H et al. Sporadic gastric Peutz-Jeghers polyp with intraepithelial neoplasia. APMIS. 2009;117:941–943.CrossRefPubMed
16.
go back to reference Arima S, Kunimura T, Matsuo K et al. Solitary Peutz-Jeghers type colorectal polyp with hamartoma–adenoma–carcinoma sequence in a non-Peutz–Jeghers syndrome patient. Showa Univ J Med Sci 2010;22:69–72.CrossRef Arima S, Kunimura T, Matsuo K et al. Solitary Peutz-Jeghers type colorectal polyp with hamartoma–adenoma–carcinoma sequence in a non-Peutz–Jeghers syndrome patient. Showa Univ J Med Sci 2010;22:69–72.CrossRef
17.
go back to reference Lunca S, Porumb V, Velenciuc N et al. Giant solitary gastric Peutz-Jeghers polyp mimicking a malignant gastric tumor: the largest described in literature. J Gastrointestin Liver Dis. 2014;23:321–324.CrossRefPubMed Lunca S, Porumb V, Velenciuc N et al. Giant solitary gastric Peutz-Jeghers polyp mimicking a malignant gastric tumor: the largest described in literature. J Gastrointestin Liver Dis. 2014;23:321–324.CrossRefPubMed
18.
go back to reference Kuwano H, Takano H, Sugimachi K. Solitary Peutz-Jeghers type polyp of the stomach in the absence of familial polyposis coli in a teenage boy. Endoscopy. 1989;21:188–190.CrossRefPubMed Kuwano H, Takano H, Sugimachi K. Solitary Peutz-Jeghers type polyp of the stomach in the absence of familial polyposis coli in a teenage boy. Endoscopy. 1989;21:188–190.CrossRefPubMed
19.
go back to reference Sakadamis AK, Ballas KD, Fardellas JG et al. A solitary gastric Peutz-Jeghers type polyp: report of a case. Surg Today. 2001;31:517–520.CrossRefPubMed Sakadamis AK, Ballas KD, Fardellas JG et al. A solitary gastric Peutz-Jeghers type polyp: report of a case. Surg Today. 2001;31:517–520.CrossRefPubMed
20.
go back to reference Amal Khsiba, Samir Brandai, Abdelawahebe Nakhli et al. Solitary gastric Peutz-Jeghers polyp: a case report. Pan Afr Med J. 2022;41:65. Amal Khsiba, Samir Brandai, Abdelawahebe Nakhli et al. Solitary gastric Peutz-Jeghers polyp: a case report. Pan Afr Med J. 2022;41:65.
21.
go back to reference Oncel M, Remzi FH, Church JM et al. Course and follow-up of solitary Peutz-Jeghers polyps: a case series. Int J Colorectal Dis. 2003;18:33–35.CrossRefPubMed Oncel M, Remzi FH, Church JM et al. Course and follow-up of solitary Peutz-Jeghers polyps: a case series. Int J Colorectal Dis. 2003;18:33–35.CrossRefPubMed
23.
go back to reference Yoshizawa N, Yamaguchi H, Kaminishi M. Differential diagnosis of solitary gastric Peutz-Jeghers-type polyp with stomach cancer: a case report. Int J Surg Case Rep. 2018;51:261–264.CrossRefPubMedPubMedCentral Yoshizawa N, Yamaguchi H, Kaminishi M. Differential diagnosis of solitary gastric Peutz-Jeghers-type polyp with stomach cancer: a case report. Int J Surg Case Rep. 2018;51:261–264.CrossRefPubMedPubMedCentral
25.
go back to reference O’Loughlin CJ, Taylor J, Karnam US et al. Pedunculated hamartomatous gastric polyp presenting with intermittent gastric outlet obstruction. Am J Gastroenterol 2002;97:S210.CrossRef O’Loughlin CJ, Taylor J, Karnam US et al. Pedunculated hamartomatous gastric polyp presenting with intermittent gastric outlet obstruction. Am J Gastroenterol 2002;97:S210.CrossRef
26.
go back to reference Nao Y, Hirokazu Y, Michio K. Differential diagnosis of solitary gastric Peutz-Jeghers-type polyp with stomach cancer: a case report. Int J Surg Case Rep. 2018;51:261–264.CrossRef Nao Y, Hirokazu Y, Michio K. Differential diagnosis of solitary gastric Peutz-Jeghers-type polyp with stomach cancer: a case report. Int J Surg Case Rep. 2018;51:261–264.CrossRef
27.
go back to reference Atsushi G, Jun N, Misato N et al. Solitary Peutz-Jeghers-type polyp of the stomach. Intern Med. 2020;59:2083–2084.CrossRef Atsushi G, Jun N, Misato N et al. Solitary Peutz-Jeghers-type polyp of the stomach. Intern Med. 2020;59:2083–2084.CrossRef
28.
go back to reference Hearle N, Schumacher V, Menko FH et al. Frequency and spectrum of cancers in the Peutz-Jeghers syndrome. Clin. Cancer Res. 2006;12:3209–3215.CrossRefPubMed Hearle N, Schumacher V, Menko FH et al. Frequency and spectrum of cancers in the Peutz-Jeghers syndrome. Clin. Cancer Res. 2006;12:3209–3215.CrossRefPubMed
29.
go back to reference Signoretti M, Bruno MJ, Zerboni G et al. Results of surveillance in individuals at high-risk of pancreatic cancer: A systematic review and meta-analysis. United Eur. Gastroenterol. J. 2018;6:489–499.CrossRef Signoretti M, Bruno MJ, Zerboni G et al. Results of surveillance in individuals at high-risk of pancreatic cancer: A systematic review and meta-analysis. United Eur. Gastroenterol. J. 2018;6:489–499.CrossRef
30.
go back to reference Giardiello FM, Brensinger JD, Tersmette AC et al. Very high risk of cancer in familial Peutz-Jeghers syndrome. Gastroenterology 2000;119:1447–1453.CrossRefPubMed Giardiello FM, Brensinger JD, Tersmette AC et al. Very high risk of cancer in familial Peutz-Jeghers syndrome. Gastroenterology 2000;119:1447–1453.CrossRefPubMed
31.
go back to reference Lim W, Olschwang S, Keller JJ et al. Relative frequency and morphology of cancers in STK11 mutation carriers. Gastroenterology 2004;126:1788–1794.CrossRefPubMed Lim W, Olschwang S, Keller JJ et al. Relative frequency and morphology of cancers in STK11 mutation carriers. Gastroenterology 2004;126:1788–1794.CrossRefPubMed
32.
go back to reference Rodriguez-Guzman F, Ruas JN, Cabral JGGAL et al. Chronic anemia caused by giant and solitary Peutz-Jeghers hamartomatous polyp treated by endoscopic resection. Arq Gastroenterol. 2023;60:282–284.CrossRefPubMed Rodriguez-Guzman F, Ruas JN, Cabral JGGAL et al. Chronic anemia caused by giant and solitary Peutz-Jeghers hamartomatous polyp treated by endoscopic resection. Arq Gastroenterol. 2023;60:282–284.CrossRefPubMed
33.
go back to reference Limaiem F, Bouraoui S, Lahmar A et al. Adenomatous transformation in a giant solitary Peutz–Jeghers-type hamartomatous polyp. Pathologica 2011;103:346–349.PubMed Limaiem F, Bouraoui S, Lahmar A et al. Adenomatous transformation in a giant solitary Peutz–Jeghers-type hamartomatous polyp. Pathologica 2011;103:346–349.PubMed
34.
go back to reference Aneiros J, Matamala M, Moral RGD et al. Hamartomatous solitary polyp with malignant progression in the jejunum. A histochemical and immunohistochemical study by light and electron microscopy. Acta Pathol Jpn 1988;38:1031–1040.PubMed Aneiros J, Matamala M, Moral RGD et al. Hamartomatous solitary polyp with malignant progression in the jejunum. A histochemical and immunohistochemical study by light and electron microscopy. Acta Pathol Jpn 1988;38:1031–1040.PubMed
35.
go back to reference Kitaoka F, Shiogama T, Mizutani A et al. A solitary Peutz–Jeghers-type hamartomatous polyp in the duodenum. A case report including results of mutation analysis. Digestion 2004;69:79–82.CrossRefPubMed Kitaoka F, Shiogama T, Mizutani A et al. A solitary Peutz–Jeghers-type hamartomatous polyp in the duodenum. A case report including results of mutation analysis. Digestion 2004;69:79–82.CrossRefPubMed
Metadata
Title
Gentle Giant? Giant Gastric Solitary Peutz-Jeghers Polyp
Authors
F. M. Mongardini
L. Nazzaro
G. Fuschillo
A. D’Alelio
C. Gambardella
L. Docimo
A. Lauro
V. Landolfi
Publication date
06-01-2024
Publisher
Springer US
Published in
Digestive Diseases and Sciences / Issue 2/2024
Print ISSN: 0163-2116
Electronic ISSN: 1573-2568
DOI
https://doi.org/10.1007/s10620-023-08240-5

Other articles of this Issue 2/2024

Digestive Diseases and Sciences 2/2024 Go to the issue

Invited Commentary

IBD: Who Knows Best?

Live Webinar | 27-06-2024 | 18:00 (CEST)

Keynote webinar | Spotlight on medication adherence

Live: Thursday 27th June 2024, 18:00-19:30 (CEST)

WHO estimates that half of all patients worldwide are non-adherent to their prescribed medication. The consequences of poor adherence can be catastrophic, on both the individual and population level.

Join our expert panel to discover why you need to understand the drivers of non-adherence in your patients, and how you can optimize medication adherence in your clinics to drastically improve patient outcomes.

Prof. Kevin Dolgin
Prof. Florian Limbourg
Prof. Anoop Chauhan
Developed by: Springer Medicine
Obesity Clinical Trial Summary

At a glance: The STEP trials

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.

Developed by: Springer Medicine

Highlights from the ACC 2024 Congress

Year in Review: Pediatric cardiology

Watch Dr. Anne Marie Valente present the last year's highlights in pediatric and congenital heart disease in the official ACC.24 Year in Review session.

Year in Review: Pulmonary vascular disease

The last year's highlights in pulmonary vascular disease are presented by Dr. Jane Leopold in this official video from ACC.24.

Year in Review: Valvular heart disease

Watch Prof. William Zoghbi present the last year's highlights in valvular heart disease from the official ACC.24 Year in Review session.

Year in Review: Heart failure and cardiomyopathies

Watch this official video from ACC.24. Dr. Biykem Bozkurt discusses last year's major advances in heart failure and cardiomyopathies.