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01-05-2019 | Tarry Feces | Brief Report

Histological and molecular characterization of TFEB-rearranged renal cell carcinomas

Authors: Nicolas Wyvekens, Markus Rechsteiner, Christine Fritz, Ulrich Wagner, Joëlle Tchinda, Carina Wenzel, Friederike Kuithan, Lars-Christian Horn, Holger Moch

Published in: Virchows Archiv | Issue 5/2019

Abstract

The 2016 WHO Classification of Tumors of the Urinary System recognizes microphthalmia transcription factor (MiT) family translocation carcinomas as a separate entity among renal cell carcinomas. TFE3 and transcription factor EB (TFEB) are members of the MiT family for which chromosomal rearrangements have been associated with renal cell carcinoma formation. TFEB translocation renal cell carcinoma is a rare tumor harboring a t(6;11)(p21;q12) translocation. Recently, renal cell carcinomas with TFEB amplification have been identified. TFEB amplified renal cell carcinomas have to be distinguished from TFEB-translocated renal cancer, because they may demonstrate a more aggressive behavior. Herein, we present a TFEB-translocated and a TFEB-amplified carcinoma cases and describe their distinct histological, immunohistochemical, and molecular characteristics. In addition, we review conventional morphology, immunophenotype, genetic background, and clinical outcome of TFEB-rearranged RCCs in the literature, with a special emphasis on important differential diagnoses and the diagnostic approach.

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Title: Histological and molecular characterization of TFEB-rearranged renal cell carcinomas
Authors: Nicolas Wyvekens
Markus Rechsteiner
Christine Fritz
Ulrich Wagner
Joëlle Tchinda
Carina Wenzel
Friederike Kuithan
Lars-Christian Horn
Holger Moch
Publication date: 01-05-2019
Publisher: Springer Berlin Heidelberg
Keywords: Tarry Feces
Kidney Cancer
Fluorescence in Situ Hybridization
Kidney Cancer
Tarry Feces
Kidney Cancer
Published in: Virchows Archiv / Issue 5/2019
Print ISSN: 0945-6317
Electronic ISSN: 1432-2307
DOI: https://doi.org/10.1007/s00428-019-02526-8

At a glance: The STEP trials

Springer Medicine

Histological and molecular characterization of TFEB-rearranged renal cell carcinomas

Abstract

At a glance: The STEP trials

Springer Medicine

Abstract

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