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Molecular Cancer
Published in: Molecular Cancer 1/2024

Open Access 01-12-2024 | Targeted Therapy | Review

Ferroptotic therapy in cancer: benefits, side effects, and risks

Authors: Jiandong Diao, Yuanyuan Jia, Enyong Dai, Jiao Liu, Rui Kang, Daolin Tang, Leng Han, Yingjie Zhong, Lingjun Meng

Published in: Molecular Cancer | Issue 1/2024

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Abstract

Ferroptosis is a type of regulated cell death characterized by iron accumulation and uncontrolled lipid peroxidation, leading to plasma membrane rupture and intracellular content release. Originally investigated as a targeted therapy for cancer cells carrying oncogenic RAS mutations, ferroptosis induction now exhibits potential to complement chemotherapy, immunotherapy, and radiotherapy in various cancer types. However, it can lead to side effects, including immune cell death, bone marrow impairment, liver and kidney damage, cachexia (severe weight loss and muscle wasting), and secondary tumorigenesis. In this review, we discuss the advantages and offer an overview of the diverse range of documented side effects. Furthermore, we examine the underlying mechanisms and explore potential strategies for side effect mitigation.
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Metadata
Title
Ferroptotic therapy in cancer: benefits, side effects, and risks
Authors
Jiandong Diao
Yuanyuan Jia
Enyong Dai
Jiao Liu
Rui Kang
Daolin Tang
Leng Han
Yingjie Zhong
Lingjun Meng
Publication date
01-12-2024
Publisher
BioMed Central
Published in
Molecular Cancer / Issue 1/2024
Electronic ISSN: 1476-4598
DOI
https://doi.org/10.1186/s12943-024-01999-9

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