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Molecular Cancer
Published in: Molecular Cancer 1/2024

Open Access 01-12-2024 | Metastasis | Review

Cancer-derived exosomes as novel biomarkers in metastatic gastrointestinal cancer

Authors: Danyang Zhong, Ziyuan Wang, Zhichao Ye, Yifan Wang, Xiujun Cai

Published in: Molecular Cancer | Issue 1/2024

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Abstract

Gastrointestinal cancer (GIC) is the most prevalent and highly metastatic malignant tumor and has a significant impact on mortality rates. Nevertheless, the swift advancement of contemporary technology has not seamlessly aligned with the evolution of detection methodologies, resulting in a deficit of innovative and efficient clinical assays for GIC. Given that exosomes are preferentially released by a myriad of cellular entities, predominantly originating from neoplastic cells, this confers exosomes with a composition enriched in cancer-specific constituents. Furthermore, exosomes exhibit ubiquitous presence across diverse biological fluids, endowing them with the inherent advantages of non-invasiveness, real-time monitoring, and tumor specificity. The unparalleled advantages inherent in exosomes render them as an ideal liquid biopsy biomarker for early diagnosis, prognosticating the potential development of GIC metastasis.
In this review, we summarized the latest research progress and possible potential targets on cancer-derived exosomes (CDEs) in GIC with an emphasis on the mechanisms of exosome promoting cancer metastasis, highlighting the potential roles of CDEs as the biomarker and treatment in metastatic GIC.
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Metadata
Title
Cancer-derived exosomes as novel biomarkers in metastatic gastrointestinal cancer
Authors
Danyang Zhong
Ziyuan Wang
Zhichao Ye
Yifan Wang
Xiujun Cai
Publication date
01-12-2024
Publisher
BioMed Central
Published in
Molecular Cancer / Issue 1/2024
Electronic ISSN: 1476-4598
DOI
https://doi.org/10.1186/s12943-024-01948-6

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