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Molecular Cancer
Published in: Molecular Cancer 1/2022

Open Access 01-12-2022 | Targeted Therapy | Review

Enhancing therapeutic anti-cancer responses by combining immune checkpoint and tyrosine kinase inhibition

Authors: Roger J. Daly, Andrew M. Scott, Oliver Klein, Matthias Ernst

Published in: Molecular Cancer | Issue 1/2022

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Abstract

Over the past decade, immune checkpoint inhibitor (ICI) therapy has been established as the standard of care for many types of cancer, but the strategies employed have continued to evolve. Recently, much clinical focus has been on combining targeted therapies with ICI for the purpose of manipulating the immune setpoint. The latter concept describes the equilibrium between factors that promote and those that suppress anti-cancer immunity. Besides tumor mutational load and other cancer cell-intrinsic determinants, the immune setpoint is also governed by the cells of the tumor microenvironment and how they are coerced by cancer cells to support the survival and growth of the tumor. These regulatory mechanisms provide therapeutic opportunities to intervene and reduce immune suppression via application of small molecule inhibitors and antibody-based therapies against (receptor) tyrosine kinases and thereby improve the response to ICIs. This article reviews how tyrosine kinase signaling in the tumor microenvironment can promote immune suppression and highlights how therapeutic strategies directed against specific tyrosine kinases can be used to lower the immune setpoint and elicit more effective anti-tumor immunity.
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Metadata
Title
Enhancing therapeutic anti-cancer responses by combining immune checkpoint and tyrosine kinase inhibition
Authors
Roger J. Daly
Andrew M. Scott
Oliver Klein
Matthias Ernst
Publication date
01-12-2022
Publisher
BioMed Central
Published in
Molecular Cancer / Issue 1/2022
Electronic ISSN: 1476-4598
DOI
https://doi.org/10.1186/s12943-022-01656-z

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