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Journal of Inflammation
Published in: Journal of Inflammation 1/2017

Open Access 01-12-2017 | Review

Interleukin-35 on B cell and T cell induction and regulation

Authors: Ai Huang, Lin Cheng, Miao He, Jun Nie, Jianjun Wang, Ke Jiang

Published in: Journal of Inflammation | Issue 1/2017

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Abstract

Interleukin (IL)-35 is a relatively newly discovered member of IL-12 cytokine family that is unique in that it is a dimer formed by two subunits. The review documents the structure, secretion and signal transduction of IL-35, the regulation effect of IL-35 on B cells and T cells as well as the adoptive transfer of IL-35+ regulatory B cells (Breg), therapeutic prospects of recombinant IL-35 (rIL-35) and IL-35 regulation role in various diseases. B-cell regulation expands the regulatory range of IL-35 and alters the view that IL-10 is the chief immune mechanism for Breg cells which secrete IL-35. IL-35 induces Breg cells, which then can induce Treg cells. IL-35 also plays an immunomodulatory role in the human body.
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Metadata
Title
Interleukin-35 on B cell and T cell induction and regulation
Authors
Ai Huang
Lin Cheng
Miao He
Jun Nie
Jianjun Wang
Ke Jiang
Publication date
01-12-2017
Publisher
BioMed Central
Published in
Journal of Inflammation / Issue 1/2017
Electronic ISSN: 1476-9255
DOI
https://doi.org/10.1186/s12950-017-0164-5

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