Skip to main content
Top
Published in: Rheumatology International 12/2009

01-10-2009 | Case Report

Successful twin pregnancy while on cyclophosphamide therapy in a patient with lupus nephritis

Authors: Rajiva Gupta, S. Deepanjali, M. M. Thabah, P. Kaur, S. Gupta

Published in: Rheumatology International | Issue 12/2009

Login to get access

Excerpt

Intravenous pulse cyclophosphamide is the standard therapy for the treatment of lupus nephritis [1]. Menstrual irregularities and premature ovarian failure can result from the prolonged use of cyclophosphamide [2, 3]. The teratogenic potential of cyclophosphamide has also been reported [4], and its effect has been proven in humans [5]. Its effect on pregnancy outcomes has not been studied well. We report a case of successful twin pregnancy during treatment with cyclophosphamide in a patient with lupus nephritis. …
Literature
1.
go back to reference Steinberg AD, Steinberg SC (1991) Long-term preservation of renal function in patients with lupus nephritis receiving treatment that includes cyclophosphamide versus those treated with prednisone only. Arthritis Rheum 34:945–950. doi:10.1002/art.1780340803 PubMedCrossRef Steinberg AD, Steinberg SC (1991) Long-term preservation of renal function in patients with lupus nephritis receiving treatment that includes cyclophosphamide versus those treated with prednisone only. Arthritis Rheum 34:945–950. doi:10.​1002/​art.​1780340803 PubMedCrossRef
3.
go back to reference Boumpas DT, Austin HA, Vaughan EM et al (1993) Risk for sustained amenorrhea in patients with systemic lupus erythematosus receiving intermittent pulse cyclophosphamide therapy. Ann Intern Med 119:366–369PubMed Boumpas DT, Austin HA, Vaughan EM et al (1993) Risk for sustained amenorrhea in patients with systemic lupus erythematosus receiving intermittent pulse cyclophosphamide therapy. Ann Intern Med 119:366–369PubMed
6.
go back to reference Austin HA, Klippel JH, Balow JE et al (1986) Therapy of lupus nephritis: controlled trial of prednisone and cytotoxic drugs. N Engl J Med 314:614–619PubMed Austin HA, Klippel JH, Balow JE et al (1986) Therapy of lupus nephritis: controlled trial of prednisone and cytotoxic drugs. N Engl J Med 314:614–619PubMed
8.
go back to reference Huong DL, Amoura Z, Duhaut P et al (2002) Risk of ovarian failure and fertility after intravenous cyclophosphamide. A study in 84 patients. J Rheumatol 9:2571–2576 Huong DL, Amoura Z, Duhaut P et al (2002) Risk of ovarian failure and fertility after intravenous cyclophosphamide. A study in 84 patients. J Rheumatol 9:2571–2576
Metadata
Title
Successful twin pregnancy while on cyclophosphamide therapy in a patient with lupus nephritis
Authors
Rajiva Gupta
S. Deepanjali
M. M. Thabah
P. Kaur
S. Gupta
Publication date
01-10-2009
Publisher
Springer-Verlag
Published in
Rheumatology International / Issue 12/2009
Print ISSN: 0172-8172
Electronic ISSN: 1437-160X
DOI
https://doi.org/10.1007/s00296-009-0860-4

Other articles of this Issue 12/2009

Rheumatology International 12/2009 Go to the issue
Live Webinar | 27-06-2024 | 18:00 (CEST)

Keynote webinar | Spotlight on medication adherence

Live: Thursday 27th June 2024, 18:00-19:30 (CEST)

WHO estimates that half of all patients worldwide are non-adherent to their prescribed medication. The consequences of poor adherence can be catastrophic, on both the individual and population level.

Join our expert panel to discover why you need to understand the drivers of non-adherence in your patients, and how you can optimize medication adherence in your clinics to drastically improve patient outcomes.

Prof. Kevin Dolgin
Prof. Florian Limbourg
Prof. Anoop Chauhan
Developed by: Springer Medicine
Obesity Clinical Trial Summary

At a glance: The STEP trials

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.

Developed by: Springer Medicine

Highlights from the ACC 2024 Congress

Year in Review: Pediatric cardiology

Watch Dr. Anne Marie Valente present the last year's highlights in pediatric and congenital heart disease in the official ACC.24 Year in Review session.

Year in Review: Pulmonary vascular disease

The last year's highlights in pulmonary vascular disease are presented by Dr. Jane Leopold in this official video from ACC.24.

Year in Review: Valvular heart disease

Watch Prof. William Zoghbi present the last year's highlights in valvular heart disease from the official ACC.24 Year in Review session.

Year in Review: Heart failure and cardiomyopathies

Watch this official video from ACC.24. Dr. Biykem Bozkurt discusses last year's major advances in heart failure and cardiomyopathies.