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01-10-2009 | Letter to the Editors

Early onset neutropenia after mycophenolate mofetil in systemic sclerosis

Authors: Giovanna Cuomo, Giuseppina Abignano, Gabriele Valentini

Published in: Rheumatology International | Issue 12/2009

Excerpt

Mycophenolate mofetil (MMF), by inhibiting the de novo synthesis of purines, displays potent immunosuppressive properties on B and T lymphocytes and is now widely used in transplant medicine [1, 2] and lupus nephritis [3, 4]. Moreover, MMF inhibits the proliferation of vascular smooth muscle cells [5] and fibroblasts [6], thereby suggesting that the drug might be effective in diseases such a scleroderma [7‐9], in which fibrotic process are prominent. …

Ciancio G, Miller J, Gonwa TA (2005) Review of major clinical trial with mycophenolate mofetil in renal transplantation. Transplantation 80 (2 Suppl):S191–S200. doi:10.1097/01.tp.0000187035.22298.ba PubMedCrossRef

Kobashigawa JA, Meiser BM (2005) Review of major clinical trials with mycophenolate mofetil in cardiac transplantation. Transplantation 80 (2 Suppl):S235–S243. doi:10.1097/01.tp.0000186383.22264.b3 PubMedCrossRef

Chan TM, Li FK, Tang CS et al (2000) Efficacy of mycophenolate mofetil in patients with diffuse proliferative lupus nephritis. Hong Kong-Guangzhou Nephrology Study Group. N Engl J Med 343:1156–1162. doi:10.1056/NEJM200010193431604 PubMedCrossRef

Ginzler EM, Dooley MA, Aranow C et al (2005) Mycophenolate mofetil or intravenous cyclophosphamide for lupus nephritis. N Engl J Med 353:2219–2228. doi:10.1056/NEJMoa043731 PubMedCrossRef

Shimizu H, Takahashi M, Takeda S et al (2004) Mycophenolate mofetil prevents transplant ateriosclerosis by direct inhibition of vascular smooth muscle cell proliferation. Transplantation 77:1661–1667. doi:10.1097/01.TP.0000127592.13707.B6 PubMedCrossRef

Miljkovic DJ, Cvetkovic I (2003) STOSIC-GRUJICIC, TRAJKOVIC V: mycophenolate acid inhibits activation of inducible nitric oxide synthase in rodent fibroblasts. Clin Exp Immunol 132:239–246. doi:10.1046/j.1365-2249.2003.02140.x PubMedCrossRef

Liossis SN, Bounas A, Andonopoulos AP (2006) Mycophenolate mofetil as first-line treatment improves clinically evident early scleroderma lung disease. Rheumatology 45:1005–1008. doi:10.1093/rheumatology/kei211 PubMedCrossRef

Nihtyanova SI, Brough GM, Black CM, Denton CP (2007) Mycophenolate mofetil in diffuse cutaneous systemic sclerosis—a retrospective analysis. Rheumatology 46:442–445. doi:10.1093/rheumatology/kel244 PubMedCrossRef

Vanthuyne M, Blockmans D, Westhovens R et al (2007) A pilot study of mycophenolate mofetil combined to intravenous methylprednisolone pulses and oral low-dose glucocorticoids in severe early systemic sclerosis. Clin Exp Rheumatol 25:287–292PubMed

10.

Nogueras F, Espinosa MD, Mansilia A et al (2005) Mycophenolate mofetil-induce neutropania in liver transplantation. Transplant Proc 37:1509–1511. doi:10.1016/j.transproceed.2005.02.038 PubMedCrossRef

Title: Early onset neutropenia after mycophenolate mofetil in systemic sclerosis
Authors: Giovanna Cuomo
Giuseppina Abignano
Gabriele Valentini
Publication date: 01-10-2009
Publisher: Springer-Verlag
Published in: Rheumatology International / Issue 12/2009
Print ISSN: 0172-8172
Electronic ISSN: 1437-160X
DOI: https://doi.org/10.1007/s00296-009-0879-6

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