Skip to main content
Top
Published in: The Egyptian Journal of Neurology, Psychiatry and Neurosurgery 1/2021

Open Access 01-12-2021 | Parkinson's Disease | Research

Functional gait assessment in early and advanced Parkinson’s disease

Authors: Hany Mohamed Eldeeb, Heba Samir Abdelraheem

Published in: The Egyptian Journal of Neurology, Psychiatry and Neurosurgery | Issue 1/2021

Login to get access

Abstract

Background

Postural instability and balance problems in patients with Parkinson’s disease (PD) can seriously affect the quality of life and lead to falls with a subsequent increase in the morbidity and mortality. Early identification of gait dysfunction in early stages of PD establishes an effective therapy, prevention of the falls and reducing health care costs. This work aimed to detect gait disorders in patients with PD using the functional gait assessment (FGA) scale and to correlate it with the disease severity in Egyptian PD patients. This is a case–control study in which 40 patients with PD were recruited from the Involuntary Movement Clinic at Alexandria University El-Hadara Hspoital; 20 patients had early stages of PD (Hoehn Yahr stages 1 and 2) and 20 patients had advanced PD (Hoehn Yahr stages 3 and 4). Another 20 subjects were recruited as controls. All recruited subjects underwent gait assessment using FGA scale.

Results

Gait analysis using FGA showed significant differences (P < 0.001) between the recruited PD patients and the control group. Upon comparing the early and advanced PD patients’ groups, certain items in the FGA (gait with pivot turn, step over obstacle, gait with eyes closed and backward gait) together with time consumed for 6-m walk with eyes open and close showed significant statistical differences between early and advanced PD patients. The patients’ duration of illness with PD was reversely correlated with the total FGA score.

Conclusion

The FGA scale was strongly influenced by the duration of PD among the Egyptian patients and can potentially detect early stages of PD.
Literature
2.
go back to reference Chen P, Wang R, Liou D, Shaw J. Gait disorders in Parkinson’s disease: assessment and management. Int J Gerontol. 2013;7(4):189–93.CrossRef Chen P, Wang R, Liou D, Shaw J. Gait disorders in Parkinson’s disease: assessment and management. Int J Gerontol. 2013;7(4):189–93.CrossRef
3.
go back to reference Petersen C, Steffen T, Paly E, Dvorak L, Nelson R. Reliability and minimal detectable change for sit-to-stand tests and the functional gait assessment for individuals with Parkinson disease. J Geriatr Phys Ther. 2017;40(4):223–6.PubMedCrossRef Petersen C, Steffen T, Paly E, Dvorak L, Nelson R. Reliability and minimal detectable change for sit-to-stand tests and the functional gait assessment for individuals with Parkinson disease. J Geriatr Phys Ther. 2017;40(4):223–6.PubMedCrossRef
4.
go back to reference Rocca WA. The burden of Parkinson’s disease: a worldwide perspective. Lancet Neurol. 2018;17(11):928–9.PubMedCrossRef Rocca WA. The burden of Parkinson’s disease: a worldwide perspective. Lancet Neurol. 2018;17(11):928–9.PubMedCrossRef
5.
go back to reference El-Tallawy HN, Farghaly WM, Shehata GA, Rageh TA, Hakeem NM, Hamed MA, et al. Prevalence of Parkinson’s disease and other types of Parkinsonism in Al Kharga district, Egypt. Neuropsychiatr Dis Treat. 2013;9:1821–6.PubMedPubMedCentral El-Tallawy HN, Farghaly WM, Shehata GA, Rageh TA, Hakeem NM, Hamed MA, et al. Prevalence of Parkinson’s disease and other types of Parkinsonism in Al Kharga district, Egypt. Neuropsychiatr Dis Treat. 2013;9:1821–6.PubMedPubMedCentral
6.
go back to reference Khedr EM, Fawi G, Abbas MA, Mohammed TA, El-Fetoh NA, Attar GA, et al. Prevalence of Parkinsonism and Parkinson’s disease in Qena governorate/Egypt: a cross-sectional community-based survey. Neurol Res. 2015;37(7):607–18.PubMedCrossRef Khedr EM, Fawi G, Abbas MA, Mohammed TA, El-Fetoh NA, Attar GA, et al. Prevalence of Parkinsonism and Parkinson’s disease in Qena governorate/Egypt: a cross-sectional community-based survey. Neurol Res. 2015;37(7):607–18.PubMedCrossRef
7.
go back to reference Khedr EM, Al Attar GS, Kandil MR, Kamel NF, Abo Elfetoh N, Ahmed MA. Epidemiological study and clinical profile of Parkinson’s disease in the Assiut Governorate, Egypt: a community-based study. Neuroepidemiology. 2012;38(3):154–63.PubMedCrossRef Khedr EM, Al Attar GS, Kandil MR, Kamel NF, Abo Elfetoh N, Ahmed MA. Epidemiological study and clinical profile of Parkinson’s disease in the Assiut Governorate, Egypt: a community-based study. Neuroepidemiology. 2012;38(3):154–63.PubMedCrossRef
8.
go back to reference Koh S, Park K, Lee D, Kim S, Yoon J. Gait analysis in patients with Parkinson’s disease: relationship to clinical features and freezing. J Mov Disord. 2008;1(2):59–64.CrossRef Koh S, Park K, Lee D, Kim S, Yoon J. Gait analysis in patients with Parkinson’s disease: relationship to clinical features and freezing. J Mov Disord. 2008;1(2):59–64.CrossRef
9.
go back to reference Ospina BM, Chaparro JA, Paredes JD, Pino YJ, Navarro A, Orozco JL. Age matters: objective gait assessment in early parkinson’s disease using an RGB-D camera. Parkinson’s Dis. 2019;6:1–9. Ospina BM, Chaparro JA, Paredes JD, Pino YJ, Navarro A, Orozco JL. Age matters: objective gait assessment in early parkinson’s disease using an RGB-D camera. Parkinson’s Dis. 2019;6:1–9.
10.
go back to reference Yang Y, Wang Y, Zhou Y, Chen C, Xing D. Reliability of functional gait assessment in patients with Parkinson disease: interrater and intrarater reliability and internal consistency. Medicine. 2016;95(34):e4545.PubMedPubMedCentralCrossRef Yang Y, Wang Y, Zhou Y, Chen C, Xing D. Reliability of functional gait assessment in patients with Parkinson disease: interrater and intrarater reliability and internal consistency. Medicine. 2016;95(34):e4545.PubMedPubMedCentralCrossRef
11.
go back to reference Bloem BR, Grimbergen YAM, Cramer M, Willemsen M, Zwinderman AH. Prospective assessment of falls in Parkinson’s disease. J Neurol. 2001;248:950–8.CrossRefPubMed Bloem BR, Grimbergen YAM, Cramer M, Willemsen M, Zwinderman AH. Prospective assessment of falls in Parkinson’s disease. J Neurol. 2001;248:950–8.CrossRefPubMed
12.
go back to reference Crouse JJ, Phillips JR, Jahanshahi M, Moustafa AA. Postural instability and falls in Parkinson’s disease. Rev Neurosci. 2016;27(5):549–55.PubMedCrossRef Crouse JJ, Phillips JR, Jahanshahi M, Moustafa AA. Postural instability and falls in Parkinson’s disease. Rev Neurosci. 2016;27(5):549–55.PubMedCrossRef
13.
go back to reference Pickering RM, Grimbergen YA, Rigney U, Ashburn A, Mazibrada G, Wood B, et al. A meta-analysis of six prospective studies of falling in Parkinson’s disease. Mov Disord. 2007;22(13):1892–900.PubMedCrossRef Pickering RM, Grimbergen YA, Rigney U, Ashburn A, Mazibrada G, Wood B, et al. A meta-analysis of six prospective studies of falling in Parkinson’s disease. Mov Disord. 2007;22(13):1892–900.PubMedCrossRef
14.
go back to reference Bohnen NI, Müller MLTM, Koeppe RA, Studenski SA, Kilbourn MA, Frey KA, et al. History of falls in Parkinson disease is associated with reduced cholinergic activity. Neurology. 2009;73(20):1670–6.PubMedPubMedCentralCrossRef Bohnen NI, Müller MLTM, Koeppe RA, Studenski SA, Kilbourn MA, Frey KA, et al. History of falls in Parkinson disease is associated with reduced cholinergic activity. Neurology. 2009;73(20):1670–6.PubMedPubMedCentralCrossRef
15.
go back to reference Leddy AL, Crowner BE, Earhart GM. Functional gait assessment and balance evaluation system test: reliability, validity, sensitivity, and specificity for identifying individuals with Parkinson disease who fall. Phys Ther. 2011;91:102–13.PubMedPubMedCentralCrossRef Leddy AL, Crowner BE, Earhart GM. Functional gait assessment and balance evaluation system test: reliability, validity, sensitivity, and specificity for identifying individuals with Parkinson disease who fall. Phys Ther. 2011;91:102–13.PubMedPubMedCentralCrossRef
16.
go back to reference Adkin AL, Frank JS, Jog MS. Fear of falling and postural control in Parkinson’s disease. Mov Disord. 2003;18(5):496–502.PubMedCrossRef Adkin AL, Frank JS, Jog MS. Fear of falling and postural control in Parkinson’s disease. Mov Disord. 2003;18(5):496–502.PubMedCrossRef
17.
go back to reference Wrisley DM, Kumar NA. Functional gait assessment: concurrent, discriminative, and predictive validity in community-dwelling older adults. Phys Ther. 2010;90:761–73.PubMedCrossRef Wrisley DM, Kumar NA. Functional gait assessment: concurrent, discriminative, and predictive validity in community-dwelling older adults. Phys Ther. 2010;90:761–73.PubMedCrossRef
18.
go back to reference Wrisley DM, Marchetti GF, Kuharsky DK, Whitney SL. Reliability, internal consistency, and validity of data obtained with the Functional Gait Assessment. Phys Ther. 2004;84:906–18.PubMedCrossRef Wrisley DM, Marchetti GF, Kuharsky DK, Whitney SL. Reliability, internal consistency, and validity of data obtained with the Functional Gait Assessment. Phys Ther. 2004;84:906–18.PubMedCrossRef
19.
go back to reference Wrisley DM, Walker ML, Echternach JL, Strasnick B. Reliability of the dynamic gait index in people with vestibular disorders. Arch Phys Med Rehabil. 2003;84(10):1528–33.PubMedCrossRef Wrisley DM, Walker ML, Echternach JL, Strasnick B. Reliability of the dynamic gait index in people with vestibular disorders. Arch Phys Med Rehabil. 2003;84(10):1528–33.PubMedCrossRef
20.
go back to reference Yang Y, Wang Y, Zhou Y, Chen C, Xing D, Wang C. Validity of the functional gait assessment in patients with Parkinson disease: construct, concurrent, and predictive validity. Phys Ther. 2014;94(3):392–400.PubMedCrossRef Yang Y, Wang Y, Zhou Y, Chen C, Xing D, Wang C. Validity of the functional gait assessment in patients with Parkinson disease: construct, concurrent, and predictive validity. Phys Ther. 2014;94(3):392–400.PubMedCrossRef
21.
go back to reference Huang S-L, Hsieh C-L, Wu R-M, Tai C-H, Lin C-H, Lu W-S. Minimal detectable change of the Timed “Up and Go” Test and the Dynamic Gait Index in people with Parkinson disease. Phys Ther. 2011;91:114–21.PubMedCrossRef Huang S-L, Hsieh C-L, Wu R-M, Tai C-H, Lin C-H, Lu W-S. Minimal detectable change of the Timed “Up and Go” Test and the Dynamic Gait Index in people with Parkinson disease. Phys Ther. 2011;91:114–21.PubMedCrossRef
22.
go back to reference Shumway-Cook A, Baldwin M, Polissar NL, Gruber W. Predicting the probability for falls in community-dwelling older adults. Phys Ther. 1997;77:812–9.PubMedCrossRef Shumway-Cook A, Baldwin M, Polissar NL, Gruber W. Predicting the probability for falls in community-dwelling older adults. Phys Ther. 1997;77:812–9.PubMedCrossRef
23.
go back to reference Hoops S, Nazem S, Siderowf AD, Duda JE, Xie SX, Stern MB, et al. Validity of the MoCA and MMSE in the detection of MCI and dementia in Parkinson disease. Neurology. 2009;73:1738–45.PubMedPubMedCentralCrossRef Hoops S, Nazem S, Siderowf AD, Duda JE, Xie SX, Stern MB, et al. Validity of the MoCA and MMSE in the detection of MCI and dementia in Parkinson disease. Neurology. 2009;73:1738–45.PubMedPubMedCentralCrossRef
24.
go back to reference Marsili L, Rizzo G, Colosimo C. Diagnostic criteria for Parkinson’s disease: from James Parkinson to the concept of prodromal disease. Front Neurol. 2018;9:156.PubMedPubMedCentralCrossRef Marsili L, Rizzo G, Colosimo C. Diagnostic criteria for Parkinson’s disease: from James Parkinson to the concept of prodromal disease. Front Neurol. 2018;9:156.PubMedPubMedCentralCrossRef
25.
go back to reference Goetz CG, Poewe W, Rascol O, Sampaio C, Stebbins GT, Counsell C, et al. Movement Disorder Society Task Force report on the Hoehn and Yahr staging scale: status and recommendations. Mov Disord. 2004;19(9):1020–8.PubMedCrossRef Goetz CG, Poewe W, Rascol O, Sampaio C, Stebbins GT, Counsell C, et al. Movement Disorder Society Task Force report on the Hoehn and Yahr staging scale: status and recommendations. Mov Disord. 2004;19(9):1020–8.PubMedCrossRef
26.
go back to reference Duncan RP, Leddy AL, Cavanaugh JT, Dibble LE, Ellis TD, Ford MP, et al. Accuracy of fall prediction in Parkinson disease: six-month and 12-month prospective analyses. Parkinson’s Dis. 2012;2012:237673. Duncan RP, Leddy AL, Cavanaugh JT, Dibble LE, Ellis TD, Ford MP, et al. Accuracy of fall prediction in Parkinson disease: six-month and 12-month prospective analyses. Parkinson’s Dis. 2012;2012:237673.
27.
go back to reference Roiz RDM, Pazinatto MM, Cliquet A, Cacho EWA, Reis JG, Barasnevicius-Quagliato EMA. Gait analysis comparing Parkinson’s disease with healthy elderly subjects. Arq Neuropsiquiatr. 2010;68(1):81–6.CrossRef Roiz RDM, Pazinatto MM, Cliquet A, Cacho EWA, Reis JG, Barasnevicius-Quagliato EMA. Gait analysis comparing Parkinson’s disease with healthy elderly subjects. Arq Neuropsiquiatr. 2010;68(1):81–6.CrossRef
28.
go back to reference Baltadjieva R, Giladi N, Gruendlinger L, Peretz C, Hausdorff JM. Marked alterations in the gait timing and rhythmicity of patients with de novo Parkinson’s disease. Eur J Neurosci. 2006;24(6):1815–20.PubMedCrossRef Baltadjieva R, Giladi N, Gruendlinger L, Peretz C, Hausdorff JM. Marked alterations in the gait timing and rhythmicity of patients with de novo Parkinson’s disease. Eur J Neurosci. 2006;24(6):1815–20.PubMedCrossRef
29.
go back to reference Sofuwa O, Nieuwboer A, Desloovere K, Willems AM, Chavret F, Jonkers I. Quantitative gait analysis in Parkinson’s disease: comparison with a healthy control group. Arch Phys Med Rehabil. 2005;86(5):1007–13.PubMedCrossRef Sofuwa O, Nieuwboer A, Desloovere K, Willems AM, Chavret F, Jonkers I. Quantitative gait analysis in Parkinson’s disease: comparison with a healthy control group. Arch Phys Med Rehabil. 2005;86(5):1007–13.PubMedCrossRef
30.
go back to reference Henry SM, Fung J, Horak FB. Effect of stance width on multidirectional postural responses. J Neurophysiol. 2001;85:559–70.PubMedCrossRef Henry SM, Fung J, Horak FB. Effect of stance width on multidirectional postural responses. J Neurophysiol. 2001;85:559–70.PubMedCrossRef
31.
go back to reference Rocchi L, Chiari L, Mancini M, Carlson-Kuhta P, Gross A, Horak FB. Step initiation in Parkinson’s disease: influence of initial stance conditions. Neurosci Lett. 2006;406(1–2):128–32.PubMedCrossRef Rocchi L, Chiari L, Mancini M, Carlson-Kuhta P, Gross A, Horak FB. Step initiation in Parkinson’s disease: influence of initial stance conditions. Neurosci Lett. 2006;406(1–2):128–32.PubMedCrossRef
32.
go back to reference Carpenter MG, Allum JH, Honegger F, Adkin AL, Bloem BR. Postural abnormalities to multidirectional stance perturbations in Parkinson’s disease. J Neurol Neurosurg Psychiatry. 2004;75(9):1245–54.PubMedPubMedCentralCrossRef Carpenter MG, Allum JH, Honegger F, Adkin AL, Bloem BR. Postural abnormalities to multidirectional stance perturbations in Parkinson’s disease. J Neurol Neurosurg Psychiatry. 2004;75(9):1245–54.PubMedPubMedCentralCrossRef
33.
go back to reference Song J, Sigward S, Fisher B, Salem GJ. Altered dynamic postural control during step turning in persons with early-stage Parkinson’s disease. Parkinson’s Dis. 2012;2012:386962. Song J, Sigward S, Fisher B, Salem GJ. Altered dynamic postural control during step turning in persons with early-stage Parkinson’s disease. Parkinson’s Dis. 2012;2012:386962.
34.
go back to reference Stack E, Jupp K, Ashburn A. Developing methods to evaluate how people with Parkinson’s Disease turn 180 degrees: an activity frequently associated with falls. Disabil Rehabil. 2004;26(8):478–84.PubMedCrossRef Stack E, Jupp K, Ashburn A. Developing methods to evaluate how people with Parkinson’s Disease turn 180 degrees: an activity frequently associated with falls. Disabil Rehabil. 2004;26(8):478–84.PubMedCrossRef
35.
go back to reference Crenna P, Carpinella I, Rabuffetti M, Calabrese E, Mazzoleni P, Nemni R, et al. The association between impaired turning and normal straight walking in Parkinson’s disease. Gait Posture. 2007;26(2):172–8.PubMedCrossRef Crenna P, Carpinella I, Rabuffetti M, Calabrese E, Mazzoleni P, Nemni R, et al. The association between impaired turning and normal straight walking in Parkinson’s disease. Gait Posture. 2007;26(2):172–8.PubMedCrossRef
36.
go back to reference Stack E, Ashburn A. Dysfunctional turning in Parkinson’s disease. Disabil Rehabil. 2008;30(16):1222–9.PubMedCrossRef Stack E, Ashburn A. Dysfunctional turning in Parkinson’s disease. Disabil Rehabil. 2008;30(16):1222–9.PubMedCrossRef
37.
go back to reference Imai T, Moore ST, Raphan T, Cohen B. Interaction of the body, head, and eyes during walking and turning. Exp Brain Res. 2001;136(1):1–18.PubMedCrossRef Imai T, Moore ST, Raphan T, Cohen B. Interaction of the body, head, and eyes during walking and turning. Exp Brain Res. 2001;136(1):1–18.PubMedCrossRef
38.
go back to reference Stack EL, Ashburn AM, Jupp KE. Strategies used by people with Parkinson’s disease who report difficulty turning. Parkinsonism Relat Disord. 2006;12(2):87–92.PubMedCrossRef Stack EL, Ashburn AM, Jupp KE. Strategies used by people with Parkinson’s disease who report difficulty turning. Parkinsonism Relat Disord. 2006;12(2):87–92.PubMedCrossRef
39.
go back to reference Simpson JM, Worsfold C, Reilly E, Nye N. A standard procedure for using TURN180: testing dynamic postural stability among elderly people. Physiotherapy. 2002;88(6):342–53.CrossRef Simpson JM, Worsfold C, Reilly E, Nye N. A standard procedure for using TURN180: testing dynamic postural stability among elderly people. Physiotherapy. 2002;88(6):342–53.CrossRef
40.
go back to reference Rinalduzzi S, Trompetto C, Marinelli L, Alibardi A, Missori P, Fattapposta F, et al. Balance dysfunction in Parkinson’s disease. BioMed Res Int. 2015;2015:434683.PubMedPubMedCentralCrossRef Rinalduzzi S, Trompetto C, Marinelli L, Alibardi A, Missori P, Fattapposta F, et al. Balance dysfunction in Parkinson’s disease. BioMed Res Int. 2015;2015:434683.PubMedPubMedCentralCrossRef
41.
go back to reference Paquette C, Franzen E, Jones GM, Horak FB. Walking in circles: navigation deficits from Parkinson’s disease but not from cerebellar ataxia. Neuroscience. 2011;190:177–83.PubMedCrossRef Paquette C, Franzen E, Jones GM, Horak FB. Walking in circles: navigation deficits from Parkinson’s disease but not from cerebellar ataxia. Neuroscience. 2011;190:177–83.PubMedCrossRef
42.
go back to reference Ebersbach G, Gunkel M. Posturography reflects clinical imbalance in Parkinson’s disease. Mov Disord. 2011;26(2):241–6.PubMedCrossRef Ebersbach G, Gunkel M. Posturography reflects clinical imbalance in Parkinson’s disease. Mov Disord. 2011;26(2):241–6.PubMedCrossRef
43.
go back to reference Barbosa AF, Chen J, Freitag F, Valente D, Souza CO, Voos MC, et al. Gait, posture and cognition in Parkinson’s disease. Dement Neuropsychol. 2016;10(4):280–6.PubMedPubMedCentralCrossRef Barbosa AF, Chen J, Freitag F, Valente D, Souza CO, Voos MC, et al. Gait, posture and cognition in Parkinson’s disease. Dement Neuropsychol. 2016;10(4):280–6.PubMedPubMedCentralCrossRef
44.
go back to reference Morris ME, Huxham F, McGinley J, Dodd K, Lansek R. The biomechanics and motor control of gait in Parkinson disease. Clin Biomech (Bristol, Avon). 2001;16(6):459–70.CrossRef Morris ME, Huxham F, McGinley J, Dodd K, Lansek R. The biomechanics and motor control of gait in Parkinson disease. Clin Biomech (Bristol, Avon). 2001;16(6):459–70.CrossRef
45.
go back to reference Geurts AC, Boonstra TA, Voermans NC, Diender MG, Weerdesteyn V, Bloem BR. Assessment of postural asymmetry in mild to moderate Parkinson’s disease. Gait Posture. 2011;33(1):143–5.PubMedCrossRef Geurts AC, Boonstra TA, Voermans NC, Diender MG, Weerdesteyn V, Bloem BR. Assessment of postural asymmetry in mild to moderate Parkinson’s disease. Gait Posture. 2011;33(1):143–5.PubMedCrossRef
46.
go back to reference Chastan N, Debono B, Maltete D, Weber J. Discordance between measured postural instability and absence of clinical symptoms in Parkinson’s disease patients in the early stages of the disease. Mov Disord. 2008;23(3):366–72.PubMedCrossRef Chastan N, Debono B, Maltete D, Weber J. Discordance between measured postural instability and absence of clinical symptoms in Parkinson’s disease patients in the early stages of the disease. Mov Disord. 2008;23(3):366–72.PubMedCrossRef
47.
go back to reference Jacobs JV, Horak FB. Abnormal proprioceptive-motor integration contributes to hypometric postural responses of subjects with Parkinson’s disease. Neuroscience. 2006;141(2):999–1009.PubMedCrossRef Jacobs JV, Horak FB. Abnormal proprioceptive-motor integration contributes to hypometric postural responses of subjects with Parkinson’s disease. Neuroscience. 2006;141(2):999–1009.PubMedCrossRef
48.
go back to reference Peterka RJ. Sensorimotor integration in human postural control. J Neurophysiol. 2002;88:1097–118.PubMedCrossRef Peterka RJ. Sensorimotor integration in human postural control. J Neurophysiol. 2002;88:1097–118.PubMedCrossRef
49.
go back to reference Almeida QJ, Frank JS, Roy EA, Jenkins ME, Spaulding S, Patla AE, et al. An evaluation of sensorimotor integration during locomotion toward a target in Parkinson’s disease. Neuroscience. 2005;134(1):283–93.PubMedCrossRef Almeida QJ, Frank JS, Roy EA, Jenkins ME, Spaulding S, Patla AE, et al. An evaluation of sensorimotor integration during locomotion toward a target in Parkinson’s disease. Neuroscience. 2005;134(1):283–93.PubMedCrossRef
50.
go back to reference Bosek M, Grzegorzewski B, Kowalczyk A, Lubinski I. Degradation of postural control system as a consequence of Parkinson’s disease and ageing. Neurosci Lett. 2005;376(3):215–20.PubMedCrossRef Bosek M, Grzegorzewski B, Kowalczyk A, Lubinski I. Degradation of postural control system as a consequence of Parkinson’s disease and ageing. Neurosci Lett. 2005;376(3):215–20.PubMedCrossRef
51.
go back to reference Giladi N, Herman T, Reider G II, Gurevich T, Hausdorff JM. Clinical characteristics of elderly patients with a cautious gait of unknown origin. J Neurol. 2005;252(3):300–6.PubMedCrossRef Giladi N, Herman T, Reider G II, Gurevich T, Hausdorff JM. Clinical characteristics of elderly patients with a cautious gait of unknown origin. J Neurol. 2005;252(3):300–6.PubMedCrossRef
53.
go back to reference Herssens N, Verbecque E, Hallemans A, Vereeck L, Van Rompaey V, Saeys W. Do spatiotemporal parameters and gait variability differ across the lifespan of healthy adults? A systematic review. Gait Posture. 2018;64:181–90.PubMedCrossRef Herssens N, Verbecque E, Hallemans A, Vereeck L, Van Rompaey V, Saeys W. Do spatiotemporal parameters and gait variability differ across the lifespan of healthy adults? A systematic review. Gait Posture. 2018;64:181–90.PubMedCrossRef
54.
55.
Metadata
Title
Functional gait assessment in early and advanced Parkinson’s disease
Authors
Hany Mohamed Eldeeb
Heba Samir Abdelraheem
Publication date
01-12-2021
Publisher
Springer Berlin Heidelberg
DOI
https://doi.org/10.1186/s41983-021-00399-w

Other articles of this Issue 1/2021

The Egyptian Journal of Neurology, Psychiatry and Neurosurgery 1/2021 Go to the issue