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Clinical Oral Investigations

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06-10-2023 | Stomatitis Aphthosa | Review

The relationship between Helicobacter pylori infection and recurrent aphthous stomatitis: a systematic review and meta-analysis

Authors: Jiayan Shen, Zhenyan Ye, Haohui Xie, Danhua Ling, Yue Wu, Yun Chen

Published in: Clinical Oral Investigations | Issue 11/2023

Abstract

Objective

This meta-analysis was designed to provide new insights into the relationship between Helicobacter pylori (H. pylori) infection and recurrent aphthous stomatitis (RAS).

Materials and methods

We included and evaluated studies on H. pylori infection and RAS from PubMed, EMBASE, Cochrane Library, and Web of Science databases published up to January 31, 2023. The characteristics of these studies were collected, and the quality was evaluated by Newcastle-Ottawa Scale (NOS). The random effects model was used to calculate the pooled odds ratio (OR) and 95% confidence interval (CI). To further explore the sources of heterogeneity, meta-regression analysis and subgroup analyses were performed. Funnel plot, Egger’s test, and Begg’s test were used to assess publication bias.

Results

In total, fifteen case-control studies with 1137 individuals (601 cases and 536 controls) were included. The H. pylori was found to be significantly associated with RAS (OR: 1.83 95% CI: 1.41–2.37, P = 0.001). In the subgroup analyses, studies that used PCR (OR: 2.03 95% CI: 1.31–3.15) or UBT (OR: 1.83 95% CI: 1.13–2.96) yielded a significant positive association, while a non-significant association (OR: 1.12 95% CI: 0.61–2.08) was found from studies that used ELISA method. Sensitivity analyses showed that the results were robust. No significant publication bias was found.

Conclusions

The current evidence does not rule out an association between H. pylori and RAS. The effect of H. pylori on RAS varies in detection methods and sources of sample. Large samples, multiple clinical studies, and improved methods are still needed to determine the exact effect of H. pylori on RAS.

Clinical significance

H. pylori infection may be a risk factor for the pathogenesis of RAS.

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Title: The relationship between Helicobacter pylori infection and recurrent aphthous stomatitis: a systematic review and meta-analysis
Authors: Jiayan Shen
Zhenyan Ye
Haohui Xie
Danhua Ling
Yue Wu
Yun Chen
Publication date: 06-10-2023
Publisher: Springer Berlin Heidelberg
Keywords: Stomatitis Aphthosa
Helicobacter Pylori
Published in: Clinical Oral Investigations / Issue 11/2023
Print ISSN: 1432-6981
Electronic ISSN: 1436-3771
DOI: https://doi.org/10.1007/s00784-023-05273-y

Keynote webinar | Spotlight on medication adherence

Springer Medicine

The relationship between Helicobacter pylori infection and recurrent aphthous stomatitis: a systematic review and meta-analysis

Abstract

Objective

Materials and methods

Results

Conclusions

Clinical significance

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Objective

Materials and methods

Results

Conclusions

Clinical significance

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