Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress 2023 EHA Congress 2023 ASCO Annual Meeting
Clinical Collections
Advances in Alzheimer’s

At a glance: The ONWARDS insulin icodec trials

A round-up of the ONWARDS phase 3 clinical trials evaluating the novel weekly insulin icodec in people with diabetes.
ADVANCED SEARCH
Log in
Top
Clinical Oral Investigations
Published in: Clinical Oral Investigations 1/2020

01-01-2020 | Oral Cancer | Review

Association of Helicobacter pylori with oral potentially malignant disorders and oral squamous cell carcinoma—a systematic review and meta-analysis

Authors: Archana A. Gupta, Supriya Kheur, A. Thirumal Raj, Pratiksha Mahajan

Published in: Clinical Oral Investigations | Issue 1/2020

Login to get access

Abstract

Objective

To assess any potential association between Helicobacter pylori and oral squamous cell carcinoma/oral potentially malignant disorders.

Materials and methods

Data mining was done using PubMed, Cochrane Library, and SCOPUS databases. The search included articles published up to May 2019. Newcastle-Ottawa scale was used to score the quality of the included articles. Data including the type of study, the sample population, the type of oral lesion, and the resulting statistical data were extracted.

Results

Out of 131 screened articles, only 15 articles fulfilled the eligibility criteria. Among the 15 studies, 9 focused on oral squamous cell carcinoma and 6 focused on oral potentially malignant disorders. Eight out of the 9 oral squamous cell carcinoma studies were included in the meta-analysis. Forest plot was generated using the odds ratio and confidence intervals calculated for each of the included studies. Due to the lack of sufficient studies, the meta-analysis was not performed for oral potentially malignant disorders.

Conclusion

Due to the contradictory results of the included studies, it was not possible to make any conclusive statement on the potential association of H. pylori with oral squamous cell carcinoma. The variations in the methodology, especially the differences in the sensitivity/specificity of the diagnostic modalities could be the cause for differential results.

Clinical relevance

Although the association of H. pylori with oral squamous cell carcinoma could not be confirmed, it is vital to reduce the excess oral microbial load, especially in patients exhibiting oral mucosal changes with no history of associated risk factors.
Literature
1.
Brown LM (2000) Helicobacter pylori: epidemiology and routes of transmission. Epidemiol Rev 22(2):283–297CrossRef
2.
Blaser MJ (2006) Who are we? Indigenous microbes and the ecology of human diseases. EMBO Rep 7(10):956–960CrossRef
3.
Liu H, Merrell DS, Semino-Mora C, Goldman M, Rahman A, Mog S, Dubois A (2009) Diet synergistically affects helicobacter pylori-induced gastric carcinogenesis in non-human primates. Gastroenterology 137(4):1367–1379CrossRef
4.
Fuccio L, Zagari RM, Eusebi LH, Laterza L, Cennamo V, Ceroni L, Grilli D, Bazzoli F (2009) Meta-analysis: can Helicobacter pylori eradication treatment reduce the risk for gastric cancer? Ann Intern Med 151(2):121–128CrossRef
5.
Sokic-Milutinovic A, Popovic D, Alempijevic T, Dragasevic S, Lukic S, Pavlovic-Markovic A (2014) Helicobacter pylori infection and gastric cancer — is eradication enough to prevent gastric cancer. In: Roesler B (ed) Trends in Helicobacter pylori infection. In Tech, Rijeka, pp 155–173
6.
Dye BA, Kruszon-Moran D, McQuillan G (2002) The relationship between periodontal disease attributes and Helicobacter pylori infection among adults in the United States. Am J Public Health 92:1809–1815CrossRef
7.
Adler I, Muiño A, Aguas S, Harada L, Diaz M, Lence A, Labbrozzi M, Muiño JM, Elsner B, Avagnina A, Denninghoff V (2014) Helicobacter pylori and oral pathology: relationship with the gastric infection. World J Gastroenterol 20(29):9922–9935CrossRef
8.
Oliver BJ, Bond RP, van Zyl WB, Delport M, Slavik T, Ziady C, Terhaar Sive Droste JS, Lastovica A, van der Merwe SW (2006) Absence of Helicobacter pylori within the oral cavities of members of a healthy South African community. J Clin Microbiol 44:635–636CrossRef
9.
Ishihara K, Miura T, Kimizuka R, Ebihara Y, Mizuno Y, Okuda K (1997) Oral bacteria inhibit Helicobacter pylori growth. FEMS Microbiol Lett 152:355–361CrossRef
10.
Umeda M, Kobayashi H, Takeuchi Y, Hayashi J, Morotome-Hayashi Y, Yano K, Aoki A, Ohkusa T, Ishikawa I (2003) High prevalence of Helicobacter pylori detected by PCR in the oral cavities of periodontitis patients. J Periodontol 74:129–134CrossRef
11.
Kazanowska-Dygdala M, Dus I, Radwan-Oczko M (2016) The presence of Helicobacter pylori in oral cavities of patients with leukoplakia and oral lichen planus. J Appl Oral Sci 24(1):18–23CrossRef
12.
Pourshahidi S, Fakhri F, Ebrahimi H, Fakhraei B, Alipour A, Ghapanchi J, Farjadian S (2012) Lack of association between Helicobacter pylori infection and oral lichen planus. Asian Pac J Cancer Prev 13:1745–1747CrossRef
13.
Attia EAS, Abdel Fattah NSA, Abdella HM (2009) Upper gastrointestinal findings and detection of Helicobacter pylori in patients with oral lichen planus. Clin Exp Dermatol 35:355–360CrossRef
14.
Hulimavu SR, Mohanty L, Tondikulam NV, Shenoy S, Jamadar S, Bhadranna A (2014) No evidence for Helicobacter pylori in oral lichen planus. J Oral Pathol Med 43:576–578CrossRef
15.
Shimoyama T, Horie N, Kato T, Kaneko T, Komiyamat K (2000) Helicobacter pylori in oral ulcerations. J Oral Sci 42:225–229CrossRef
16.
Zenouz AT, Mehdipour M, Heydarlou MJ, Gholizadeh N (2010) Relationship between Lichen planus and Helicobacter pylori infection. J Dent Res Dent Clin Dent Prospect 4(1):17–20
17.
Chen M, Chen J, Yang Y, Cheng L, Wu HT (2018) Possible association between Helicobacter pylori infection and vocal fold leukoplakia. Head Neck:1–10
18.
19.
Viganò L, Cinzia C, Oliveira A, Guerrieri P (2018) Helicobacter pylori: is there an association with oral pathologies? A Traditional Review. Acta Sci Microbiol:32–39
20.
Dayama A, Srivastava V, Shukla M, Singh R, Pandey M (2011) Helicobacter pylori and oral cancer: Possible association in a preliminary case control study. Asian Pac J Cancer Prev 12:1333–1336PubMed
21.
Fernando N, Jayakumar G, Perera N, Amarasingha I, Meedin F, Holton J (2009) Presence of Helicobacter pylori in betel chewers and non-betel chewers with and without oral cancers. BMC Oral Health 9:23–28CrossRef
22.
Grimm M, Munz A, Exarchou A, Polligkeit J, Reinert S (2014) Immunohistochemical detection of Helicobacter pylori without association of TLR5 expression in oral squamous cell carcinoma. J Oral Pathol Med 43:35–44CrossRef
23.
Meng X, Wang Q, He C, Chen M, Liu J, Liu W, Yuan Y (2016) An inverse association of Helicobacter pylori infection with oral squamous cell carcinoma. J Oral Pathol Med 45:17–22CrossRef
24.
Okuda K, Ishihara K, Miura T, Katakura A, Noma H, Ebihara Y (2000) Helicobacter pylori may have only a transient presence in the oral cavity and on the surface of oral cancer. Microbiol Immunol 44(5):385–388CrossRef
25.
Ravali CT (2017) Association of Helicobacter pylori in oral cancer patients. Int J Appl Dent Sci 3(3):185–192
26.
Sharma P, Gawande M, Chaudhary M (2015) Evaluation of prevalence of bacteria Helicobacter pylori in potentially malignant disorders and oral squamous cell carcinoma. World J Dent 6(2):82–86CrossRef
27.
Irani S, Esfahani AM, Zerehpoush FB (2013) Detection of Helicobacter pylori in oral lesions. J Dent Res Dent Clin Dent Prospect 7(4):230–237
28.
Gupta AA, Kheur S, Mamatha GS, Shetty L, Kheur M (2016) Helicobacter pylori as a risk indicator of oral squamous cell carcinoma – a PCR based study. Int Jr Current Research 8(7):34109–34119
29.
Chang MC, Kuo MY, Hahn LJ, Hsieh CC, Lin SK, Jeng JH (1998) Areca nut extract inhibits the growth, attachment, and matrix protein synthesis of cultured human gingival fibroblasts. J Periodontol 69(10):1092–1097CrossRef
30.
Hung SL, Chen YL, Wan HC, Liu TY, Chen YT, Ling LJ (2000) Effects of areca nut extracts on the functions of human neutrophils in vitro. J Periodontal Res 35(4):186–193CrossRef
31.
de Miranda CM, van Wyk CW, van der Biji P, Basson NJ (1996) The effect of areca nut on salivary and selected oral microorganisms. Int Dent J 46(4):350–356PubMed
32.
Gebara EC, Pannuti C, Faria CM, Chehter L, Mayer MP, Lima LA (2004) Prevalence of Helicobacter pylori detected by polymerase chain reaction in the oral cavity of periodontitis patients. Oral Microbiol Immunol 19(4):277–280CrossRef
33.
Shaykhiev R, Behr J, Bals R (2008) Microbial patterns signaling via Toll-like receptors 2 and 5 contribute to epithelial repair, growth and survival. PLoS One 3:e1393CrossRef
34.
Eusebi LH, Zagari RM, Bazzoli F (2014) Epidemiology of Helicobacter pylori infection. Helicobacter. 19(Suppl 1):1–5CrossRef
Metadata
Title
Association of Helicobacter pylori with oral potentially malignant disorders and oral squamous cell carcinoma—a systematic review and meta-analysis
Authors
Archana A. Gupta
Supriya Kheur
A. Thirumal Raj
Pratiksha Mahajan
Publication date
01-01-2020
Publisher
Springer Berlin Heidelberg
Published in
Clinical Oral Investigations / Issue 1/2020
Print ISSN: 1432-6981
Electronic ISSN: 1436-3771
DOI
https://doi.org/10.1007/s00784-019-03125-2

Other articles of this Issue 1/2020

Clinical Oral Investigations 1/2020 Go to the issue

Original Article

Comparison of laser- and bur-prepared class I cavities restored with two different low-shrinkage composite resins: a randomized, controlled 60-month clinical trial

Original Article

PRF improves wound healing and postoperative discomfort after harvesting subepithelial connective tissue graft from palate: a randomized controlled trial

Letter to the Editor

Letter to the editor replying to Holliday et al. about the article published in clinical oral investigations titled “Impact of cigarette smoking and vaping on the outcome of full-mouth ultrasonic scaling among patients with gingival inflammation: a prospective study”

Review

Oral health–related quality of life (OHRQoL) before and after endodontic treatment: a systematic review

Original Article

Maxillofacial injuries in severely injured patients after road traffic accidents—a retrospective evaluation of the TraumaRegister DGU® 1993–2014

Original Article

Residual monomer elution from different conventional and CAD/CAM dental polymers during artificial aging