Published in:
Open Access 01-12-2018 | Research
Stochastic lattice-based modelling of malaria dynamics
Published in: Malaria Journal | Issue 1/2018
Login to get accessAbstract
Background
The transmission of malaria is highly variable and depends on a range of climatic and anthropogenic factors. In addition, the dispersal of Anopheles mosquitoes is a key determinant that affects the persistence and dynamics of malaria. Simple, lumped-population models of malaria prevalence have been insufficient for predicting the complex responses of malaria to environmental changes.
Methods and results
A stochastic lattice-based model that couples a mosquito dispersal and a susceptible-exposed-infected-recovered epidemics model was developed for predicting the dynamics of malaria in heterogeneous environments. The It\(\hat{o}\) approximation of stochastic integrals with respect to Brownian motion was used to derive a model of stochastic differential equations. The results show that stochastic equations that capture uncertainties in the life cycle of mosquitoes and interactions among vectors, parasites, and hosts provide a mechanism for the disruptions of malaria. Finally, model simulations for a case study in the rural area of Kilifi county, Kenya are presented.
Conclusions
A stochastic lattice-based integrated malaria model has been developed. The applicability of the model for capturing the climate-driven hydrologic factors and demographic variability on malaria transmission has been demonstrated.