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Journal of Gastroenterology
Published in: Journal of Gastroenterology 9/2016

Open Access 01-09-2016 | Review

Stem cell dynamics and pretumor progression in the intestinal tract

Authors: Huiying Ma, Folkert H. M. Morsink, George Johan Arnold Offerhaus, Wendy W. J. de Leng

Published in: Journal of Gastroenterology | Issue 9/2016

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Abstract

Colorectal carcinogenesis is a process that follows a stepwise cascade that goes from the normal to an invisible pretumor stage ultimately leading to grossly visible tumor progression. During pretumor progression, an increasing accumulation of genetic alterations occurs, by definition without visible manifestations. It is generally thought that stem cells in the crypt base are responsible for this initiation of colorectal cancer progression because they are the origin of the differentiated epithelial cells that occupy the crypt. Furthermore, they are characterized by a long life span that enables them to acquire these cumulative mutations. Recent studies visualized the dynamics of stem cells both in vitro and in vivo. Translating this work into clinical applications will contribute to the evaluation of patients’ predisposition for colorectal carcinogenesis and may help in the design of preventive measures for high-risk groups. In this review, we outline the progress made in the research into tracing stem cell dynamics. Further, we highlight the importance and potential clinical value of tracing stem cell dynamics in pretumor progression.
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Metadata
Title
Stem cell dynamics and pretumor progression in the intestinal tract
Authors
Huiying Ma
Folkert H. M. Morsink
George Johan Arnold Offerhaus
Wendy W. J. de Leng
Publication date
01-09-2016
Publisher
Springer Japan
Published in
Journal of Gastroenterology / Issue 9/2016
Print ISSN: 0944-1174
Electronic ISSN: 1435-5922
DOI
https://doi.org/10.1007/s00535-016-1211-3

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