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Molecular Cancer
Published in: Molecular Cancer 1/2002

Open Access 01-12-2002 | Review

Mitochondrial defects in cancer

Authors: Jennifer S Carew, Peng Huang

Published in: Molecular Cancer | Issue 1/2002

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Abstract

Mitochondria play important roles in cellular energy metabolism, free radical generation, and apoptosis. Defects in mitochondrial function have long been suspected to contribute to the development and progression of cancer. In this review article, we aim to provide a brief summary of our current understanding of mitochondrial genetics and biology, review the mtDNA alterations reported in various types of cancer, and offer some perspective as to the emergence of mtDNA mutations, their functional consequences in cancer development, and therapeutic implications.
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Metadata
Title
Mitochondrial defects in cancer
Authors
Jennifer S Carew
Peng Huang
Publication date
01-12-2002
Publisher
BioMed Central
Published in
Molecular Cancer / Issue 1/2002
Electronic ISSN: 1476-4598
DOI
https://doi.org/10.1186/1476-4598-1-9

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