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Clinical and Experimental Medicine
Published in: Clinical and Experimental Medicine 1/2016

01-02-2016 | Review Article

Stem cell autograft and allograft in autoimmune diseases

Authors: Angelo De Cata, Angela Matarangolo, Michele Inglese, Rosa Rubino, Gianluigi Mazzoccoli

Published in: Clinical and Experimental Medicine | Issue 1/2016

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Abstract

Autoimmune diseases are characterized by an insufficiency of immune tolerance and, although treated with a number of useful drugs, may need more unconventional therapeutic strategies for their more severe presentations. Among such unconventional therapeutic approaches, stem cell autograft and allograft have been used, with the aim of stimulating disease remission by modifying the pathogenic mechanisms that induce anomalous responses against self-antigens. Autologous transplantation is performed with the purpose of retuning autoimmune cells, whereas allogeneic transplantation is performed with the purpose of replacing anomalous immune effectors and mediators. In this article, we comprehensively review up-to-date information on the autoimmune diseases for which the transplantation of stem cells is indicated.
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Metadata
Title
Stem cell autograft and allograft in autoimmune diseases
Authors
Angelo De Cata
Angela Matarangolo
Michele Inglese
Rosa Rubino
Gianluigi Mazzoccoli
Publication date
01-02-2016
Publisher
Springer International Publishing
Published in
Clinical and Experimental Medicine / Issue 1/2016
Print ISSN: 1591-8890
Electronic ISSN: 1591-9528
DOI
https://doi.org/10.1007/s10238-014-0330-5

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