Issue 1/2015
Content (69 Articles)
Aβ reduction in BACE1 heterozygous null 5XFAD mice is associated with transgenic APP level
Katherine R Sadleir, William A Eimer, Sarah L Cole, Robert Vassar
Heteromers of amyloid precursor protein in cerebrospinal fluid
Inmaculada Cuchillo-Ibañez, Inmaculada Lopez-Font, Alba Boix-Amorós, Gunnar Brinkmalm, Kaj Blennow, Jose-Luis Molinuevo, Javier Sáez-Valero
Intrathecal heat shock protein 60 mediates neurodegeneration and demyelination in the CNS through a TLR4- and MyD88-dependent pathway
Karen Rosenberger, Paul Dembny, Katja Derkow, Odilo Engel, Christina Krüger, Susanne A Wolf, Helmut Kettenmann, Eckart Schott, Andreas Meisel, Seija Lehnardt
Opposing effects of viral mediated brain expression of apolipoprotein E2 (apoE2) and apoE4 on apoE lipidation and Aβ metabolism in apoE4-targeted replacement mice
Jin Hu, Chia-Chen Liu, Xiao-Fen Chen, Yun-wu Zhang, Huaxi Xu, Guojun Bu
APOE4 enhances age-dependent decline in cognitive function by down-regulating an NMDA receptor pathway in EFAD-Tg mice
De-shan Liu, Xiao-dong Pan, Jing Zhang, Hui Shen, Nicole C Collins, Arron M Cole, Kevin P Koster, Manel Ben Aissa, Xiao-man Dai, Meng Zhou, Leon M Tai, Yuan-gui Zhu, Mary Jo LaDu, Xiao-chun Chen
Posttranslational modification and mutation of histidine 50 trigger alpha synuclein aggregation and toxicity
Wei Xiang, Stefanie Menges, Johannes CM Schlachetzki, Holger Meixner, Anna-Carin Hoffmann, Ursula Schlötzer-Schrehardt, Cord-Michael Becker, Jürgen Winkler, Jochen Klucken
An automated image analysis method to measure regularity in biological patterns: a case study in a Drosophila neurodegenerative model
Sergio Diez-Hermano, Jorge Valero, Cristina Rueda, Maria D Ganfornina, Diego Sanchez
Active immunization against alpha-synuclein ameliorates the degenerative pathology and prevents demyelination in a model of multiple system atrophy
Markus Mandler, Elvira Valera, Edward Rockenstein, Michael Mante, Harald Weninger, Christina Patrick, Anthony Adame, Sabine Schmidhuber, Radmila Santic, Achim Schneeberger, Walter Schmidt, Frank Mattner, Eliezer Masliah
Lazarillo-related Lipocalins confer long-term protection against type I Spinocerebellar Ataxia degeneration contributing to optimize selective autophagy
Manuela del Caño-Espinel, Judith R Acebes, Diego Sanchez, Maria D Ganfornina
Effects of CD2-associated protein deficiency on amyloid-β in neuroblastoma cells and in an APP transgenic mouse model
Fan Liao, Hong Jiang, Subhashini Srivatsan, Qingli Xiao, Katheryn B Lefton, Kaoru Yamada, Thomas E Mahan, Jin-Moo Lee, Andrey S Shaw, David M Holtzman
Aβ-induced degradation of BMAL1 and CBP leads to circadian rhythm disruption in Alzheimer’s disease
Hyundong Song, Minho Moon, Han Kyoung Choe, Dong-Hee Han, Changhwan Jang, Ahbin Kim, Sehyung Cho, Kyungjin Kim, Inhee Mook-Jung
Analysis of tau post-translational modifications in rTg4510 mice, a model of tau pathology
Lixin Song, Sherry X Lu, Xuesong Ouyang, Jerry Melchor, Julie Lee, Giuseppe Terracina, Xiaohai Wang, Lynn Hyde, J Fred Hess, Eric M Parker, Lili Zhang
Selective loss of glucocerebrosidase activity in sporadic Parkinson’s disease and dementia with Lewy bodies
Davide Chiasserini, Silvia Paciotti, Paolo Eusebi, Emanuele Persichetti, Anna Tasegian, Marzena Kurzawa-Akanbi, Patrick F Chinnery, Christopher M Morris, Paolo Calabresi, Lucilla Parnetti, Tommaso Beccari
Synaptic dysfunction and septin protein family members in neurodegenerative diseases
Mikael Marttinen, Kaisa MA Kurkinen, Hilkka Soininen, Annakaisa Haapasalo, Mikko Hiltunen
Promising cannabinoid-based therapies for Parkinson’s disease: motor symptoms to neuroprotection
Sandeep Vasant More, Dong-Kug Choi
Genetically-controlled Vesicle-Associated Membrane Protein 1 expression may contribute to Alzheimer’s pathophysiology and susceptibility
Daniel Sevlever, Fanggeng Zou, Li Ma, Sebastian Carrasquillo, Michael G Crump, Oliver J Culley, Talisha A Hunter, Gina D Bisceglio, Linda Younkin, Mariet Allen, Minerva M Carrasquillo, Sigrid B Sando, Jan O Aasly, Dennis W Dickson, Neill R Graff-Radford, Ronald C Petersen, Olivia Belbin
TREM2 is associated with increased risk for Alzheimer’s disease in African Americans
Sheng Chih Jin, Minerva M Carrasquillo, Bruno A Benitez, Tara Skorupa, David Carrell, Dwani Patel, Sarah Lincoln, Siddharth Krishnan, Michaela Kachadoorian, Christiane Reitz, Richard Mayeux, Thomas S Wingo, James J Lah, Allan I Levey, Jill Murrell, Hugh Hendrie, Tatiana Foroud, Neill R Graff-Radford, Alison M Goate, Carlos Cruchaga, Nilüfer Ertekin-Taner
Calcium-responsive transactivator (CREST) protein shares a set of structural and functional traits with other proteins associated with amyotrophic lateral sclerosis
Michail S Kukharsky, Annamaria Quintiero, Taisei Matsumoto, Koji Matsukawa, Haiyan An, Tadafumi Hashimoto, Takeshi Iwatsubo, Vladimir L Buchman, Tatyana A Shelkovnikova
Making (anti-) sense out of huntingtin levels in Huntington disease
Melvin M Evers, Menno H Schut, Barry A Pepers, Melek Atalar, Martine J van Belzen, Richard LM Faull, Raymund AC Roos, Willeke MC van Roon-Mom
Identification of telomere dysfunction in Friedreich ataxia
Sara Anjomani Virmouni, Sahar Al-Mahdawi, Chiranjeevi Sandi, Hemad Yasaei, Paola Giunti, Predrag Slijepcevic, Mark A. Pook
Nigral overexpression of alpha-synuclein in the absence of parkin enhances alpha-synuclein phosphorylation but does not modulate dopaminergic neurodegeneration
Anne-Sophie Van Rompuy, Marusela Oliveras-Salvá, Anke Van der Perren, Olga Corti, Chris Van den Haute, Veerle Baekelandt
Partial eNOS deficiency causes spontaneous thrombotic cerebral infarction, amyloid angiopathy and cognitive impairment
Xing-Lin Tan, Yue-Qiang Xue, Tao Ma, Xiaofang Wang, Jing Jing Li, Lubin Lan, Kafait U. Malik, Michael P. McDonald, Alejandro M. Dopico, Francesca-Fang Liao
Viral expression of ALS-linked ubiquilin-2 mutants causes inclusion pathology and behavioral deficits in mice
Carolina Ceballos-Diaz, Awilda M. Rosario, Hyo-Jin Park, Paramita Chakrabarty, Amanda Sacino, Pedro E. Cruz, Zoe Siemienski, Nicolas Lara, Corey Moran, Natalia Ravelo, Todd E. Golde, Nikolaus R. McFarland
Mutations in LRRK2 potentiate age-related impairment of autophagic flux
Shamol Saha, Peter E. A. Ash, Vivek Gowda, Liqun Liu, Orian Shirihai, Benjamin Wolozin
Prophylactic melatonin significantly reduces Alzheimer’s neuropathology and associated cognitive deficits independent of antioxidant pathways in AβPPswe/PS1 mice
G. O’Neal-Moffitt, V. Delic, P. C. Bradshaw, J. Olcese
Regulation of human MAPT gene expression
Marie-Laure Caillet-Boudin, Luc Buée, Nicolas Sergeant, Bruno Lefebvre
Cholestenoic acid, an endogenous cholesterol metabolite, is a potent γ-secretase modulator
Joo In Jung, Ashleigh R. Price, Thomas B. Ladd, Yong Ran, Hyo-Jin Park, Carolina Ceballos-Diaz, Lisa A. Smithson, Günther Hochhaus, Yufei Tang, Rajender Akula, Saritha Ba, Edward H. Koo, Gideon Shapiro, Kevin M. Felsenstein, Todd E. Golde
Reduced secreted clusterin as a mechanism for Alzheimer-associated CLU mutations
Karolien Bettens, Steven Vermeulen, Caroline Van Cauwenberghe, Bavo Heeman, Bob Asselbergh, Caroline Robberecht, Sebastiaan Engelborghs, Mathieu Vandenbulcke, Rik Vandenberghe, Peter Paul De Deyn, Marc Cruts, Christine Van Broeckhoven, Kristel Sleegers
Synaptotagmins interact with APP and promote Aβ generation
Vivek Gautam, Carla D’Avanzo, Oksana Berezovska, Rudolph E. Tanzi, Dora M. Kovacs
Studies of lipopolysaccharide effects on the induction of α-synuclein pathology by exogenous fibrils in transgenic mice
Nicola J. Rutherford, Amanda N. Sacino, Mieu Brooks, Carolina Ceballos-Diaz, Thomas B. Ladd, Jasie K. Howard, Todd E. Golde, Benoit I. Giasson
Conditional inactivation of Akt three isoforms causes tau hyperphosphorylation in the brain
Long Wang, Shanshan Cheng, Zhenyu Yin, Congyu Xu, Shuangshuang Lu, Jinxing Hou, Tingting Yu, Xiaolei Zhu, Xiaoyan Zou, Ying Peng, Yun Xu, Zhongzhou Yang, Guiquan Chen
Brca1 is expressed in human microglia and is dysregulated in human and animal model of ALS
Harun Najib Noristani, Jean Charles Sabourin, Yannick Nicolas Gerber, Marisa Teigell, Andreas Sommacal, Maria dM Vivanco, Markus Weber, Florence Evelyne Perrin
CRISPR/Cas9: a powerful genetic engineering tool for establishing large animal models of neurodegenerative diseases
Zhuchi Tu, Weili Yang, Sen Yan, Xiangyu Guo, Xiao-Jiang Li
MicroRNA-9 induces defective trafficking of Nav1.1 and Nav1.2 by targeting Navβ2 protein coding region in rat with chronic brain hypoperfusion
Li-Hua Sun, Mei-Ling Yan, Xue-Ling Hu, Li-Wei Peng, Hui Che, Ya-Nan Bao, Fei Guo, Tong Liu, Xin Chen, Rong Zhang, Tao Ban, Ning Wang, Huai-Lei Liu, Xu Hou, Jing Ai
STIM2 protects hippocampal mushroom spines from amyloid synaptotoxicity
Elena Popugaeva, Ekaterina Pchitskaya, Anastasiya Speshilova, Sergey Alexandrov, Hua Zhang, Olga Vlasova, Ilya Bezprozvanny
Human neural stem cells alleviate Alzheimer-like pathology in a mouse model
Il-Shin Lee, Kwangsoo Jung, Il-Sun Kim, Haejin Lee, Miri Kim, Seokhwan Yun, Kyujin Hwang, Jeong Eun Shin, Kook In Park
The topology of pen-2, a γ-secretase subunit, revisited: evidence for a reentrant loop and a single pass transmembrane domain
Xulun Zhang, Chunjiang J. Yu, Sangram S. Sisodia
Caspase-7: a critical mediator of optic nerve injury-induced retinal ganglion cell death
Shreyasi Choudhury, Yang Liu, Abbot F. Clark, Iok-Hou Pang
Distinct clinical and neuropathological features of G51D SNCA mutation cases compared with SNCA duplication and H50Q mutation
Aoife P. Kiely, Helen Ling, Yasmine T. Asi, Eleanna Kara, Christos Proukakis, Anthony H. Schapira, Huw R. Morris, Helen C. Roberts, Steven Lubbe, Patricia Limousin, Patrick A. Lewis, Andrew J. Lees, Niall Quinn, John Hardy, Seth Love, Tamas Revesz, Henry Houlden, Janice L. Holton
Cytoplasmic mislocalization of RNA splicing factors and aberrant neuronal gene splicing in TDP-43 transgenic pig brain
Guohao Wang, Huaqiang Yang, Sen Yan, Chuan-En Wang, Xudong Liu, Bentian Zhao, Zhen Ouyang, Peng Yin, Zhaoming Liu, Yu Zhao, Tao Liu, Nana Fan, Lin Guo, Shihua Li, Xiao-Jiang Li, Liangxue Lai
TREM2 in CNS homeostasis and neurodegenerative disease
Meghan M. Painter, Yuka Atagi, Chia-Chen Liu, Rosa Rademakers, Huaxi Xu, John D. Fryer, Guojun Bu
A novel BACE inhibitor NB-360 shows a superior pharmacological profile and robust reduction of amyloid-β and neuroinflammation in APP transgenic mice
Ulf Neumann, Heinrich Rueeger, Rainer Machauer, Siem Jacob Veenstra, Rainer M. Lueoend, Marina Tintelnot-Blomley, Grit Laue, Karen Beltz, Barbara Vogg, Peter Schmid, Wilfried Frieauff, Derya R. Shimshek, Matthias Staufenbiel, Laura H. Jacobson
Erratum to: Endogenous TDP-43, but not FUS, contributes to stress granule assembly via G3BP
Anaïs Aulas, Stéphanie Stabile, Christine Vande Velde
Frontotemporal dementia-associated N279K tau mutant disrupts subcellular vesicle trafficking and induces cellular stress in iPSC-derived neural stem cells
Melissa C. Wren, Jing Zhao, Chia-Chen Liu, Melissa E. Murray, Yuka Atagi, Mary D. Davis, Yuan Fu, Hirotaka J. Okano, Kotaro Ogaki, Audrey J. Strongosky, Pawel Tacik, Rosa Rademakers, Owen A. Ross, Dennis W. Dickson, Zbigniew K. Wszolek, Takahisa Kanekiyo, Guojun Bu
Pharmacogenetic stimulation of cholinergic pedunculopontine neurons reverses motor deficits in a rat model of Parkinson’s disease
Ilse S. Pienaar, Sarah E. Gartside, Puneet Sharma, Vincenzo De Paola, Sabine Gretenkord, Dominic Withers, Joanna L. Elson, David T. Dexter
A brain-targeted, modified neurosin (kallikrein-6) reduces α-synuclein accumulation in a mouse model of multiple system atrophy
Brian Spencer, Elvira Valera, Edward Rockenstein, Margarita Trejo-Morales, Anthony Adame, Eliezer Masliah
Erratum to: Genetically-controlled Vesicle-Associated Membrane Protein 1 expression may contribute to Alzheimer’s pathophysiology and susceptibility
Daniel Sevlever, Fanggeng Zou, Li Ma, Sebastian Carrasquillo, Michael G. Crump, Oliver J. Culley, Talisha A. Hunter, Gina D. Bisceglio, Linda Younkin, Mariet Allen, Minerva M. Carrasquillo, Sigrid B. Sando, Jan O. Aasly, Dennis W. Dickson, Neill R. Graff-Radford, Ronald C. Petersen, Ferenc Deák, Olivia Belbin
The RAB39B p.G192R mutation causes X-linked dominant Parkinson’s disease
Ignacio F. Mata, Yongwoo Jang, Chun-Hyung Kim, David S. Hanna, Michael O. Dorschner, Ali Samii, Pinky Agarwal, John W. Roberts, Olga Klepitskaya, David R. Shprecher, Kathryn A. Chung, Stewart A. Factor, Alberto J. Espay, Fredy J. Revilla, Donald S. Higgins, Irene Litvan, James B. Leverenz, Dora Yearout, Miguel Inca-Martinez, Erica Martinez, Tiffany R. Thompson, Brenna A. Cholerton, Shu-Ching Hu, Karen L. Edwards, Kwang-Soo Kim, Cyrus P. Zabetian
Ethosuximide ameliorates neurodegenerative disease phenotypes by modulating DAF-16/FOXO target gene expression
Xi Chen, Hannah V. McCue, Shi Quan Wong, Sudhanva S. Kashyap, Brian C. Kraemer, Jeff W. Barclay, Robert D. Burgoyne, Alan Morgan
Genetics ignite focus on microglial inflammation in Alzheimer’s disease
Manasi Malik, Ishita Parikh, Jared B. Vasquez, Conor Smith, Leon Tai, Guojun Bu, Mary Jo LaDu, David W. Fardo, G. William Rebeck, Steven Estus
Depletion of highly abundant proteins from human cerebrospinal fluid: a cautionary note
Ramona Günther, Eberhard Krause, Michael Schümann, Ingolf E. Blasig, Reiner F. Haseloff
Erratum to: Ethosuximide ameliorates neurodegenerative disease phenotypes by modulating DAF-16/FOXO target gene expression
Xi Chen, Hannah V. McCue, Shi Quan Wong, Sudhanva S. Kashyap, Brian C. Kraemer, Jeff W. Barclay, Robert D. Burgoyne, Alan Morgan
Analysis of in vivo turnover of tau in a mouse model of tauopathy
Kaoru Yamada, Tirth K. Patel, Katja Hochgräfe, Thomas E. Mahan, Hong Jiang, Floy R. Stewart, Eva-Maria Mandelkow, David M. Holtzman
Statins induce insulin-degrading enzyme secretion from astrocytes via an autophagy-based unconventional secretory pathway
Sung Min Son, Seokjo Kang, Heesun Choi, Inhee Mook-Jung
SOD1 protein aggregates stimulate macropinocytosis in neurons to facilitate their propagation
Rafaa Zeineddine, Jay F. Pundavela, Lisa Corcoran, Elise M. Stewart, Dzung Do-Ha, Monique Bax, Gilles Guillemin, Kara L. Vine, Danny M. Hatters, Heath Ecroyd, Christopher M. Dobson, Bradley J. Turner, Lezanne Ooi, Mark R. Wilson, Neil R. Cashman, Justin J. Yerbury
Deletion of aquaporin-4 in APP/PS1 mice exacerbates brain Aβ accumulation and memory deficits
Zhiqiang Xu, Na Xiao, Yali Chen, Huang Huang, Charles Marshall, Junying Gao, Zhiyou Cai, Ting Wu, Gang Hu, Ming Xiao
Ceruloplasmin functional changes in Parkinson’s disease-cerebrospinal fluid
Marco Barbariga, Flavio Curnis, Annapaola Andolfo, Alan Zanardi, Massimo Lazzaro, Antonio Conti, Giuseppe Magnani, Maria Antonietta Volontè, Laura Ferrari, Giancarlo Comi, Angelo Corti, Massimo Alessio
Region-specific dendritic simplification induced by Aβ, mediated by tau via dysregulation of microtubule dynamics: a mechanistic distinct event from other neurodegenerative processes
Nataliya Golovyashkina, Lorène Penazzi, Carlo Ballatore, Amos B. Smith III, Lidia Bakota, Roland Brandt
Glutaminase-containing microvesicles from HIV-1-infected macrophages and immune-activated microglia induce neurotoxicity
Beiqing Wu, Yunlong Huang, Alexander L. Braun, Zenghan Tong, Runze Zhao, Yuju Li, Fang Liu, Jialin C. Zheng
Is L-methionine a trigger factor for Alzheimer’s-like neurodegeneration?: Changes in Aβ oligomers, tau phosphorylation, synaptic proteins, Wnt signaling and behavioral impairment in wild-type mice
Cheril Tapia-Rojas, Carolina B. Lindsay, Carla Montecinos-Oliva, Macarena S. Arrazola, Rocio M. Retamales, Daniel Bunout, Sandra Hirsch, Nibaldo C. Inestrosa
Loss of parkin promotes lipid rafts-dependent endocytosis through accumulating caveolin-1: implications for Parkinson’s disease
Seon-Heui Cha, Yu Ree Choi, Cheol-Ho Heo, Seo-Jun Kang, Eun-Hye Joe, Ilo Jou, Hwan-Myung Kim, Sang Myun Park
Identification of novel CSF biomarkers for neurodegeneration and their validation by a high-throughput multiplexed targeted proteomic assay
Wendy E. Heywood, Daniela Galimberti, Emily Bliss, Ernestas Sirka, Ross W. Paterson, Nadia K. Magdalinou, Miryam Carecchio, Emma Reid, Amanda Heslegrave, Chiara Fenoglio, Elio Scarpini, Jonathan M. Schott, Nick C. Fox, John Hardy, Kailash Bahtia, Simon Heales, Neil J. Sebire, Henrik Zetterburg, Kevin Mills
Loss of Munc18-1 long splice variant in GABAergic terminals is associated with cognitive decline and increased risk of dementia in a community sample
Alfredo Ramos-Miguel, Christa Hercher, Clare L. Beasley, Alasdair M. Barr, Thomas A. Bayer, Peter Falkai, Sue E. Leurgans, Julie A. Schneider, David A. Bennett, William G. Honer
α-synuclein interacts with SOD1 and promotes its oligomerization
Anika M. Helferich, Wolfgang P. Ruf, Veselin Grozdanov, Axel Freischmidt, Marisa S. Feiler, Lisa Zondler, Albert C. Ludolph, Pamela J. McLean, Jochen H. Weishaupt, Karin M. Danzer
The N17 domain mitigates nuclear toxicity in a novel zebrafish Huntington’s disease model
Matthew B. Veldman, Yesenia Rios-Galdamez, Xiao-Hong Lu, Xiaofeng Gu, Wei Qin, Song Li, X. William Yang, Shuo Lin
Tau missorting and spastin-induced microtubule disruption in neurodegeneration: Alzheimer Disease and Hereditary Spastic Paraplegia
Hans Zempel, Eva-Maria Mandelkow
Beclin 1 regulates neuronal transforming growth factor-β signaling by mediating recycling of the type I receptor ALK5
Caitlin E. O’Brien, Liana Bonanno, Hui Zhang, Tony Wyss-Coray
Ubiquitin-specific protease 14 regulates c-Jun N-terminal kinase signaling at the neuromuscular junction
Jada H Vaden, Bula J Bhattacharyya, Ping-Chung Chen, Jennifer A Watson, Andrea G Marshall, Scott E Phillips, Julie A Wilson, Gwendalyn D King, Richard J Miller, Scott M Wilson
Anti-oxidant polydatin (piceid) protects against substantia nigral motor degeneration in multiple rodent models of Parkinson’s disease
Yupin Chen, Dong-qi Zhang, Zhong Liao, Bin Wang, Suzhen Gong, Chuang Wang, Ming-zi Zhang, Guo-hua Wang, Huaibin Cai, Francesca-Fang Liao, Jiang-ping Xu