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Investigational New Drugs

Issue 5/2008

Content (10 Articles)

PHASE II STUDIES

Plasma and tissue disposition of non-liposomal DB-67 and liposomal DB-67 in C.B-17 SCID mice

William C. Zamboni, Laura L. Jung, Sandra Strychor, Erin Joseph, Beth A. Zamboni, Sarah A. Fetterman, Brian J. Sidone, Thomas G. Burke, Dennis P. Curran, Julie L. Eiseman

PRECLINICAL STUDIES

Inhibitory effects of quercetin derivatives on phosphodiesterase isozymes and high-affinity [3 H]-rolipram binding in guinea pig tissues

Agnes L.-F. Chan, Hui-Lin Huang, Hui-Chi Chien, Chi-Ming Chen, Chun-Nan Lin, Wun-Chang Ko

PRECLINICAL STUDIES

Growth inhibition and induction of apoptosis in MCF-7 breast cancer cells by a new series of substituted-1,3,4-oxadiazole derivatives

Akhilesh Kumar, Saritha S. D’Souza, S. L. Gaonkar, K. M. L. Rai, Bharathi P. Salimath

PHASE I STUDIES

Synthesis and in vitro antiproliferative activity against human cancer cell lines of novel 5-(4-methyl-benzylidene)-thiazolidine-2,4-diones

S. Chandrappa, S. B. Benaka Prasad, K. Vinaya, C. S. Ananda Kumar, N. R. Thimmegowda, K. S. Rangappa

PHASE I STUDIES

Phase 1 study of TAS-102 administered once daily on a 5-day-per-week schedule in patients with solid tumors

Michael J. Overman, Gauri Varadhachary, Scott Kopetz, Melanie B. Thomas, Masakazu Fukushima, Keizo Kuwata, Akira Mita, Robert A. Wolff, Paulo M. Hoff, Henry Xiong, James L. Abbruzzese

PHASE I STUDIES

Effect of coadministration of ketoconazole, a strong CYP3A4 inhibitor, on pharmacokinetics and tolerability of motesanib diphosphate (AMG 706) in patients with advanced solid tumors

Patricia LoRusso, Elisabeth I. Heath, Jesse McGreivy, Yu-Nien Sun, Rebeca Melara, Lucy Yan, Lisa Malburg, Megan Ingram, Jeffrey Wiezorek, Li Chen, Mary Jo Pilat

PHASE II STUDIES

A phase II study evaluating bevacizumab in combination with fixed-dose rate gemcitabine and low-dose cisplatin for metastatic pancreatic cancer: is an anti-VEGF strategy still applicable?

Andrew H. Ko, Elizabeth Dito, Brian Schillinger, Alan P. Venook, Zhidong Xu, Emily K. Bergsland, Derrick Wong, Janet Scott, Jimmy Hwang, Margaret A. Tempero

PHASE II STUDIES

Favorable survival observed after carboplatin, paclitaxel, and concurrent accelerated hyperfractionated radiotherapy for treatment of locally advanced head and neck carcinoma

Dennis L. Carter, Lina Asmar, David Barrera, John Caracandas, J. Shaker Dakhil, Dean McCracken, Mark A. O’Rourke, Richard K. Rosenberg, Kristi A. Boehm, Des Ilegbodu, Robert L. Reid

PHASE II STUDIES

Early phase II trial of oral vorinostat in relapsed or refractory breast, colorectal, or non-small cell lung cancer

Johan Vansteenkiste, Eric Van Cutsem, Herlinde Dumez, Cong Chen, Justin L. Ricker, Sophia S. Randolph, Patrick Schöffski

Webinar | 19-02-2024 | 17:30 (CET)

Keynote webinar | Spotlight on antibody–drug conjugates in cancer

Antibody–drug conjugates (ADCs) are novel agents that have shown promise across multiple tumor types. Explore the current landscape of ADCs in breast and lung cancer with our experts, and gain insights into the mechanism of action, key clinical trials data, existing challenges, and future directions.

Dr. Véronique Diéras
Prof. Fabrice Barlesi
Developed by: Springer Medicine