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Investigational New Drugs

Issue 4/2005

Content (13 Articles)

Tumor and normal tissue pharmacokinetics of perifosine, an oral anti-cancer alkylphospholipid

Stefan R. Vink, Jan H. M. Schellens, Wim J. van Blitterswijk, Marcel Verheij

Enhanced P53 and BAX gene expression and apoptosis in A549 cells by cis-Pt(II) complex of 3-aminoflavone in comparison with cis-DDP

Beata Kosmider, Izabela Wojcik, Regina Osiecka, Jacek Bartkowiak, Elzbieta Zyner, Justyn Ochocki, Pawel Liberski

A study of cytotoxic synergy of UCN-01 and flavopiridol in syngeneic pair of cell lines

Kongming Wu, Mark D’Amico, Chenguang Wang, Chris Albanese, Richard G. Pestell, Sridhar Mani

A phase I pharmacokinetic study of the P-glycoprotein inhibitor, ONT-093, in combination with paclitaxel in patients with advanced cancer

Kim N. Chi, Stephen K. Chia, Ross Dixon, Michael J. Newman, Vince J. Wacher, Branimir Sikic, Karen A. Gelmon

Human metabolism of [14C]indisulam following i.v. infusion in cancer patients

Jan-Hendrik Beumer, Michel J. X. Hillebrand, Dick Pluim, Hilde Rosing, Karen Foley, S. Murray Yule, Jan H. M. Schellens, Jos H. Beijnen

Phase I/II study of amrubicin, a novel 9-aminoanthracycline, in patients with advanced non-small-cell lung cancer

Takahiko Sugiura, Yutaka Ariyoshi, Shunichi Negoro, Shinichiro Nakamura, Harumichi Ikegami, Minoru Takada, Takashi Yana, Masahiro Fukuoka

DE-310, a macromolecular prodrug of the topoisomerase-I-inhibitor exatecan (DX-8951), in patients with operable solid tumors

Moritz N. Wente, Jörg Kleeff, Markus W. Büchler, Jantien Wanders, Peter Cheverton, Stephen Langman, Helmut Friess

Gemcitabine and mitoxantrone in metastatic breast cancer: A phase-I-study

Peter Schmid, Bernd Flath, Konstantin Akrivakis, Volker Heilmann, Hans-Günther Mergenthaler, Orhan Sezer, Rolf Kreienberg, Kurt Possinger

Phase II study of CCI-779 in patients with recurrent glioblastoma multiforme

Susan M. Chang, Patrick Wen, Timothy Cloughesy, Harry Greenberg, David Schiff, Charles Conrad, Karen Fink, H. Ian Robins, Lisa De Angelis, Jeffrey Raizer, Kenneth Hess, Ken Aldape, Kathleen R. Lamborn, John Kuhn, Janet Dancey, Michael D. Prados

BBR 3438, a novel 9-aza-anthrapyrazole, in patients with advanced gastric cancer: A phase II study group trial of the central European Society of Anticancer-Drug Research (CESAR)

R.-D. Hofheinz, C. Porta, G. Hartung, A. Santoro, A.-R. Hanauske, K. Kutz, A. Stern, P. Barbieri, E. Verdi, R. Hehlmann, A. Hochhaus

Second-line treatment with oxaliplatin, leucovorin and 5-fluorouracil in gemcitabine-pretreated advanced pancreatic cancer: A phase II study

Nicolas Tsavaris, Christos Kosmas, Helias Skopelitis, Panagiotis Gouveris, Petros Kopteridis, Dioynissis Loukeris, Frantzeska Sigala, Alexandra Zorbala-Sypsa, Evangelos Felekouras, Efstathios Papalambros

Webinar | 19-02-2024 | 17:30 (CET)

Keynote webinar | Spotlight on antibody–drug conjugates in cancer

Antibody–drug conjugates (ADCs) are novel agents that have shown promise across multiple tumor types. Explore the current landscape of ADCs in breast and lung cancer with our experts, and gain insights into the mechanism of action, key clinical trials data, existing challenges, and future directions.

Dr. Véronique Diéras
Prof. Fabrice Barlesi
Developed by: Springer Medicine