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Investigational New Drugs

Issue 2/1998

Content (13 Articles)

Pharmaceutical development of a parenteral lyophilized formulation of the investigational antitumor neuropeptide antagonist [Arg6, D-Trp7,9, MePhe8]-Substance P {6-11}

J.D. Jonkman-de Vries, H. Rosing, H. Talsma, R.E.C. Henrar, J.J. Kettenes-van den Bosch, A. Bult, J.H. Beijnen

Activity of pivaloyloxymethyl butyrate, a novel anticancer agent, on primary human tumor colony-forming units

Lillian L. Siu, Daniel D. Von Hoff, Ada Rephaeli, Elzbieta Izbicka, Cesario Cerna, Lionel Gomez, Eric K. Rowinsky, S. Gail Eckhardt

Preclinical antitumor efficacy of analogs of XK469: sodium-(2-[4-(7-chloro-2-quinoxalinyloxy)phenoxy]propionate

Thomas H. Corbett, Patricia LoRusso, Lisa Demchick, Chiab Simpson, Susan Pugh, Kathryn White, Juiwanna Kushner, Lisa Polin, Jennifer Meyer, Jennifer Czarnecki, Lance Heilbrun, Jerome P. Horwitz, Janet L. Gross, Carl H. Behrens, Barbara A. Harrison, Ron J. McRipley, George Trainor

Gemcitabine plus dose-escalated epirubicin in advanced breast cancer: results of a phase I study

Diana Lüftner, Bernd Flath, Costa Akrivakis, Hans-Günther Mergenthaler, Ute Ohnmacht, Michael Arning, Kurt Possinger

Phase I and pharmacokinetic study of intraperitoneal topotecan

Steven C. Plaxe, Randolph D. Christen, John O'Quigley, Patricia S. Braly, James L. Freddo, Edward McClay, Dennis Heath, Stephen B. Howell

Phase II trial of oral β-all trans-retinoic acid in hepatocellular carcinoma (SWOG 9157)

Frank L. Meyskens Jr., Joth Jacobson, Bichlien Nguyen, Geoffrey R. Weiss, David R. Gandara, John S. MacDonald

Phase II study of prolonged infusion of Taxol in patients with metastatic colorectal carcinoma

Jaffer A. Ajani, Richard Pazdur, Pamela Dumas, Jackie Fairweather

Phase II trial of pyrazine diazohydroxide in androgen-independent prostate cancer

Martin J. Edelman, Frederick J. Meyers, Tim Grennan, Jun Lauder, James Doroshow

Phase II study of paclitaxel (BMS-181339) intravenously infused over 3 hours for advanced or metastatic breast cancer in Japan

Yoshinori Ito, Noboru Horikoshi, Toru Watanabe, Yasutsuna Sasaki, Takeshi Tominaga, Tomohiko Okawa, Toshio Tabei, Yasunobu Kuraishi, Kazuo Tamura, Rikiya Abe, Masaki Kitajima, Susumu Yamaguchi, Tetsuro Kobayashi, Hiroki Koyama, Kunzo Orita, Shigemitsu Takashima, Yasuo Nomura, Makoto Ogawa

Topotecan in previously treated advanced urothelial carcinoma: an ECOG phase II trial

Robert S. Witte, Judith Manola, Patrick A. Burch, Timothy Kuzel, Eric L. Weinshel, Patrick J. Loehrer Sr.

Webinar | 19-02-2024 | 17:30 (CET)

Keynote webinar | Spotlight on antibody–drug conjugates in cancer

Antibody–drug conjugates (ADCs) are novel agents that have shown promise across multiple tumor types. Explore the current landscape of ADCs in breast and lung cancer with our experts, and gain insights into the mechanism of action, key clinical trials data, existing challenges, and future directions.

Dr. Véronique Diéras
Prof. Fabrice Barlesi
Developed by: Springer Medicine