Diabetologia

TCF7L2: the biggest story in diabetes genetics since HLA?

E. Zeggini, M. I. McCarthy

TCF7L2 and type 2 diabetes—we WNT to know

U. Smith

Peroxisome proliferator-activated receptor-δ, a regulator of oxidative capacity, fuel switching and cholesterol transport

C. Fürnsinn, T. M. Willson, B. Brunmair

High prevalence of ischaemia, infection and serious comorbidity in patients with diabetic foot disease in Europe. Baseline results from the Eurodiale study

L. Prompers, M. Huijberts, J. Apelqvist, E. Jude, A. Piaggesi, K. Bakker, M. Edmonds, P. Holstein, A. Jirkovska, D. Mauricio, G. Ragnarson Tennvall, H. Reike, M. Spraul, L. Uccioli, V. Urbancic, K. Van Acker, J. van Baal, F. van Merode, N. Schaper

Impact of diabetes on haemoglobin levels in renal disease

R. Ravanan, J. R. Spiro, P. W. Mathieson, R. M. Smith

Seasonality of birth in children and young adults (0–29 years) with type 1 diabetes in Ukraine

A. M. Vaiserman, B. Carstensen, V. P. Voitenko, M. D. Tronko, V. I. Kravchenko, M. D. Khalangot, L. V. Mechova

Circulating oxidised low-density lipoprotein and intercellular adhesion molecule-1 and risk of type 2 diabetes mellitus: the Atherosclerosis Risk in Communities Study

R. C. Hoogeveen, C. M. Ballantyne, H. Bang, G. Heiss, B. B. Duncan, A. R. Folsom, J. S. Pankow

Relationships of maternal and paternal birthweights to features of the metabolic syndrome in adult offspring: an inter-generational study in South India

S. R. Veena, S. Geetha, S. D. Leary, J. Saperia, D. J. Fisher, K. Kumaran, P. Coakley, C. E. Stein, C. H. D. Fall

Age, overweight and physical inactivity increase the risk of latent autoimmune diabetes in adults: results from the Nord-Trøndelag health study

S. Carlsson, K. Midthjell, M. Y. Tesfamarian, V. Grill

Association of variants of transcription factor 7-like 2 (TCF7L2) with susceptibility to type 2 diabetes in the Dutch Breda cohort

J. V. van Vliet-Ostaptchouk, R. Shiri-Sverdlov, A. Zhernakova, E. Strengman, T. W. van Haeften, M. H. Hofker, C. Wijmenga

Common variants in the TCF7L2 gene are strongly associated with type 2 diabetes mellitus in the Indian population

G. R. Chandak, C. S. Janipalli, S. Bhaskar, S. R. Kulkarni, P. Mohankrishna, A. T. Hattersley, T. M. Frayling, C. S. Yajnik

An association analysis of the HLA gene region in latent autoimmune diabetes in adults

M. Desai, E. Zeggini, V. A. Horton, K. R. Owen, A. T. Hattersley, J. C. Levy, M. Walker, K. M. Gillespie, P. J. Bingley, G. A. Hitman, R. R. Holman, M. I. McCarthy, A. Clark

Enhanced mitochondrial metabolism may account for the adaptation to insulin resistance in islets from C57BL/6J mice fed a high-fat diet

M. Fex, M. Dekker Nitert, N. Wierup, F. Sundler, C. Ling, H. Mulder

Increasing uncoupling protein-2 in pancreatic beta cells does not alter glucose-induced insulin secretion but decreases production of reactive oxygen species

N. Produit-Zengaffinen, N. Davis-Lameloise, H. Perreten, D. Bécard, A. Gjinovci, P. A. Keller, C. B. Wollheim, P. Herrera, P. Muzzin, F. Assimacopoulos-Jeannet

Human evidence for the involvement of insulin-induced gene 1 in the regulation of plasma glucose concentration

S. Krapivner, E. Chernogubova, M. Ericsson, C. Ahlbeck-Glader, A. Hamsten, F. M. van ’t Hooft

Substrate source utilisation in long-term diagnosed type 2 diabetes patients at rest, and during exercise and subsequent recovery

H. Boon, E. E. Blaak, W. H. M. Saris, H. A. Keizer, A. J. M. Wagenmakers, L. J. C. van Loon

Impaired in vivo mitochondrial function but similar intramyocellular lipid content in patients with type 2 diabetes mellitus and BMI-matched control subjects

V. B. Schrauwen-Hinderling, M. E. Kooi, M. K. C. Hesselink, J. A. L. Jeneson, W. H. Backes, C. J. A. van Echteld, J. M. A. van Engelshoven, M. Mensink, P. Schrauwen

Adult rat liver cells transdifferentiated with lentiviral IPF1 vectors reverse diabetes in mice: an ex vivo gene therapy approach

A. Fodor, C. Harel, L. Fodor, M. Armoni, P. Salmon, D. Trono, E. Karnieli

Amelioration of glucose tolerance by hepatic inhibition of nuclear factor κB in db/db mice

Y. Tamura, T. Ogihara, T. Uchida, F. Ikeda, N. Kumashiro, T. Nomiyama, F. Sato, T. Hirose, Y. Tanaka, H. Mochizuki, R. Kawamori, H. Watada

Glucagon receptor knockout mice are resistant to diet-induced obesity and streptozotocin-mediated beta cell loss and hyperglycaemia

S. L. Conarello, G. Jiang, J. Mu, Z. Li, J. Woods, E. Zycband, J. Ronan, F. Liu, R. Sinha Roy, L. Zhu, M. J. Charron, B. B. Zhang

Committed subcutaneous preadipocytes are reduced in human obesity

Y. Tchoukalova, C. Koutsari, M. Jensen

β2-Adrenergic activation increases glycogen synthesis in L6 skeletal muscle cells through a signalling pathway independent of cyclic AMP

D. L. Yamamoto, D. S. Hutchinson, T. Bengtsson

Inhibition by glucose or leptin of hypothalamic neurons expressing neuropeptide Y requires changes in AMP-activated protein kinase activity

P. D. Mountjoy, S. J. Bailey, G. A. Rutter

The effects of acute hypoglycaemia on memory acquisition and recall and prospective memory in type 1 diabetes

R. E. Warren, N. N. Zammitt, I. J. Deary, B. M. Frier

QTc interval and resting heart rate as long-term predictors of mortality in type 1 and type 2 diabetes mellitus: a 23-year follow-up

C. Stettler, A. Bearth, S. Allemann, M. Zwahlen, L. Zanchin, M. Deplazes, E. R. Christ, A. Teuscher, P. Diem

Peroxisome proliferator activated receptor gamma activity is low in mature primary human visceral adipocytes

L. Sauma, N. Franck, J. F. Paulsson, G. T. Westermark, P. Kjølhede, P. Strålfors, M. Söderström, F. H. Nystrom

Increased blood–brain barrier permeability and altered tight junctions in experimental diabetes in the rat: contribution of hyperglycaemia and matrix metalloproteinases

B. T. Hawkins, T. F. Lundeen, K. M. Norwood, H. L. Brooks, R. D. Egleton

Analysis of the type 2 diabetes gene, TCF7L2, in 13,795 type 1 diabetes cases and control subjects

S. F. Field, J. M. M. Howson, D. J. Smyth, N. M. Walker, D. B. Dunger, J. A. Todd

No major contribution of TCF7L2 sequence variants to maturity onset of diabetes of the young (MODY) or neonatal diabetes mellitus in French white subjects

S. Cauchi, M. Vaxillaire, H. Choquet, E. Durand, A. Duval, M. Polak, P. Froguel

Sitosterol and cholesterol in chylomicrons of type 2 diabetic and non-diabetic subjects: the relationship with ATP binding cassette proteins G5 and G8 and Niemann–Pick C1-like 1 mRNA

S. E. Lally, D. Owens, G. H. Tomkin

Comment on: Brugman S et al. (2006) Antibiotic treatment partially protects against type 1 diabetes in the Bio-Breeding diabetes-prone rat. Is the gut flora involved in the development of type 1 diabetes? Diabetologia 49:2105–2108

R. F. Schwartz, J. Neu, D. Schatz, M. A. Atkinson, C. Wasserfall

Comment on: Nathan DM, Buse JB, Davidson MB et al (2006) Management of hyperglycaemia in type 2 diabetes: a consensus algorithm for the initiation and adjustment of therapy. A consensus statement from the American Diabetes Association and the European Association for the Study of Diabetes. Diabetologia 49:1711–1721

P. E. Cryer

Comment on: Nathan DM, Buse JB, Davidson MB et al (2006) Management of hyperglycaemia in type 2 diabetes: a consensus algorithm for the initiation and adjustment of therapy: A consensus statement from the American Diabetes Association and the European Association for the Study of Diabetes. Diabetologia 49: 1711–1721

B. Schultes

Comment on: Nathan DM, Buse JB, Davidson MB et al. (2006) Management of hyperglycaemia in type 2 diabetes:a consensus algorithm for the initiation and adjustmentof therapy. A consensus statement from the American Diabetes Association and the European Associationfor the Study of Diabetes. Diabetologia 49:1711–1721

M. Porta, M. Trento

Comment on: Nathan DM, Buse JB, Davidson MB et al. (2006) Management of hyperglycaemia in type 2 diabetes: a consensus algorithm for the initiation and adjustment of therapy. A consensus statement from the American Diabetes Association and the European Association for the Study of Diabetes. Diabetologia 49: 1711–1721

T. Takamura, A. Shimizu, H. Ando, S. Kaneko

Response to comments on: Nathan DM, Buse JB, Davidson MB et al. (2006) Management of hyperglycaemia in type 2 diabetes: a consensus algorithm for the initiation and adjustment of therapy. A consensus statement from the American Diabetes Association and the European Association for the Study of Diabetes. Diabetologia 49:1711–1721

D. M. Nathan

Comment on: Schmidt MI, Duncan BB, Vigo A et al (2006) Leptin and incident type 2 diabetes: risk or protection? Diabetologia 49:2086–2096

M. B. Snijder, J. M. Dekker, L. M. Bouter, R. J. Heine, C. D. A. Stehouwer, J. C. Seidell

Response to comment on: Schmidt MI, Duncan BB, Vigo A et al. (2006) Leptin and incident type 2 diabetes: risk or protection? Diabetologia 49:2086–2096

M. I. Schmidt, B. B. Duncan, A. Vigo, J. S. Pankow, D. Couper, C. M. Ballantyne, R. C. Hoogeveen, G. Heiss

Comment on: Schmidt MI, Duncan BB, Vigo A et al. (2006) Leptin and incident type 2 diabetes: risk or protection? Diabetologia 49:2086–2096

J. R. S. Arch

Comment on: Tseng C-H, Tseng C-P, Chong C-K et al (2006) Increasing incidence of diagnosed type 2 diabetes in Taiwan: analysis of data from a national cohort. Diabetologia 49:1755–1760

T. H.-H. Chen, B. J. Boucher

Response to comment on: Tseng C-H, Tseng C-P, Chong C-K et al (2006) Increasing incidence of diagnosed type 2 diabetes in Taiwan: analysis of data from a national cohort. Diabetologia 49:1755–1760

C.-H. Tseng

Type 2 diabetes and cardiovascular risk in the UK south Asian community

A. H. Barnett, A. N. Dixon, S. Bellary, M. W. Hanif, J. P. O’Hare, N. T. Raymond, S. Kumar

List of Referees