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03-01-2023 | Spironolactone | Review

Diuretics in pediatrics

Authors: Sebastiano A. G. Lava, Chiara Zollinger, Hassib Chehade, Damien Schaffner, Nicole Sekarski, Stefano Di Bernardo

Published in: European Journal of Pediatrics | Issue 5/2023

Abstract

Diuretics are frequently prescribed drugs and help managing several pathological conditions, including acute and chronic kidney disease, nephrotic syndrome, congestive heart failure, ascites, systemic and pulmonary hypertension. Diuretic classes include among others osmotic diuretics and carboanhydrase inhibitors, loop diuretics, thiazides, and potassium-sparing diuretics. In this educational article, we aim at reviewing indications, mechanisms of action, and side effects, as well as basic pharmacokinetics considerations and data on diuretics in children, supporting practicing clinicians in choosing (and understanding the background of) the best-suited diuretic regimen for the individual patient. Newer diuretic classes like vaptans and sodium glucose type 2 cotransporter inhibitors, the recent controversies on hydrochlorothiazide, and the issue of diuretic resistance, will also be briefly addressed.

Conclusion: This educational review offers a didactical overview of diuretics in Pediatrics.

What is Known:

• Diuretics are frequently prescribed drugs in both adults and children.

• They increase water and sodium excretion, reducing fluid overload.

What is New:

• This article reviews indications, mechanisms of action, side effects, and basic pharmacokinetics facts on diuretics in Paediatrics.

• It also addresses current issues, like the management of diuretic resistance, the recent controversy on hydrochlorothiazide, and the novel classes vaptans and gliflozins.

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Title: Diuretics in pediatrics
Authors: Sebastiano A. G. Lava
Chiara Zollinger
Hassib Chehade
Damien Schaffner
Nicole Sekarski
Stefano Di Bernardo
Publication date: 03-01-2023
Publisher: Springer Berlin Heidelberg
Keywords: Spironolactone
Diuretics
Bumetanide
Hydrochlorothiazide
Furosemide
Torasemide
Pediatrics
Nephrotic Syndrome
Carbonic Anhydrase Inhibitor
Published in: European Journal of Pediatrics / Issue 5/2023
Print ISSN: 0340-6199
Electronic ISSN: 1432-1076
DOI: https://doi.org/10.1007/s00431-022-04768-2

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Diuretics in pediatrics

Abstract

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

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