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Journal of Mammary Gland Biology and Neoplasia

Published in:

01-06-2010

Snail Family Regulation and Epithelial Mesenchymal Transitions in Breast Cancer Progression

Authors: Antonio Garcia de Herreros, Sandra Peiró, Mayssaa Nassour, Pierre Savagner

Published in: Journal of Mammary Gland Biology and Neoplasia | Issue 2/2010

Abstract

Since its initial description, the interconversion between epithelial and mesenchymal cells (designed as epithelial-mesenchymal or mesenchymal-epithelial transition, EMT or MET, respectively) has received special attention since it provides epithelial cells with migratory features. Different studies using cell lines have identified cytokines, intercellular signaling elements and transcriptional factors capable of regulating this process. Particularly, the identification of Snail family members as key effectors of EMT has opened new ways for the study of this cellular process. In this article we discuss the molecular pathways that control EMT, showing a very tight and interdependent regulation. We also analyze the contribution of EMT and Snail genes in the process of tumorigenesis using the mammary gland as cellular model.

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Title: Snail Family Regulation and Epithelial Mesenchymal Transitions in Breast Cancer Progression
Authors: Antonio Garcia de Herreros
Sandra Peiró
Mayssaa Nassour
Pierre Savagner
Publication date: 01-06-2010
Publisher: Springer US
Published in: Journal of Mammary Gland Biology and Neoplasia / Issue 2/2010
Print ISSN: 1083-3021
Electronic ISSN: 1573-7039
DOI: https://doi.org/10.1007/s10911-010-9179-8

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Antibody–drug conjugates (ADCs) are novel agents that have shown promise across multiple tumor types. Explore the current landscape of ADCs in breast and lung cancer with our experts, and gain insights into the mechanism of action, key clinical trials data, existing challenges, and future directions.

Dr. Véronique Diéras

Prof. Fabrice Barlesi

Developed by: Springer Medicine

At a glance: The STEP trials

Springer Medicine

Abstract

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Other articles of this Issue 2/2010

Epithelial Mesenchymal Transition Traits in Human Breast Cancer Cell Lines Parallel the CD44hi/CD24lo/- Stem Cell Phenotype in Human Breast Cancer

Cell Polarity in Motion: Redefining Mammary Tissue Organization Through EMT and Cell Polarity Transitions

microRNAs and EMT in Mammary Cells and Breast Cancer

Matrix Metalloproteinase-Induced Epithelial-Mesenchymal Transition in Breast Cancer

Epithelial-Mesenchymal Transition in Cancer: Parallels Between Normal Development and Tumor Progression

Epithelial-Mesenchymal Transition (EMT) in Tumor-Initiating Cells and Its Clinical Implications in Breast Cancer

Keynote webinar | Spotlight on antibody–drug conjugates in cancer