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European Journal of Nuclear Medicine and Molecular Imaging

Published in:

01-03-2008

Smart optical probes for near-infrared fluorescence imaging of Alzheimer’s disease pathology

Authors: Scott B. Raymond, Jesse Skoch, Ivory D. Hills, Evgueni E. Nesterov, Timothy M. Swager, Brian J. Bacskai

Published in: European Journal of Nuclear Medicine and Molecular Imaging | Special Issue 1/2008

Abstract

Purpose

Near-infrared fluorescent probes for amyloid-beta (Aβ) are an exciting option for molecular imaging in Alzheimer’s disease research and may translate to clinical diagnostics. However, Aβ-targeted optical probes often suffer from poor specificity and slow clearance from the brain. We are designing smart optical probes that emit characteristic fluorescence signal only when bound to Aβ.

Methods

We synthesized a family of dyes and tested Aβ-binding sensitivity with fluorescence spectroscopy and tissue-staining.

Results

Select compounds exhibited Aβ-dependent changes in fluorescence quantum yield, lifetime, and emission spectra that may be imaged microscopically or in vivo using new lifetime and spectral fluorescence imaging techniques.

Conclusion

Smart optical probes that turn on when bound to Aβ will improve amyloid detection and may enable quantitative molecular imaging in vivo.

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Title: Smart optical probes for near-infrared fluorescence imaging of Alzheimer’s disease pathology
Authors: Scott B. Raymond
Jesse Skoch
Ivory D. Hills
Evgueni E. Nesterov
Timothy M. Swager
Brian J. Bacskai
Publication date: 01-03-2008
Publisher: Springer-Verlag
Published in: European Journal of Nuclear Medicine and Molecular Imaging / Issue Special Issue 1/2008
Print ISSN: 1619-7070
Electronic ISSN: 1619-7089
DOI: https://doi.org/10.1007/s00259-007-0708-7

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Smart optical probes for near-infrared fluorescence imaging of Alzheimer’s disease pathology

Abstract

Purpose

Methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusion

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